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July 2006

Literature Review

How prepared is Europe for pandemic influenza: Analysis of national plans
Go to full text in PubMed: Mounier-Jack S, Coker JR Lancet 2006;367;1405

The authors surveyed the National Pandemic Influenza plans for 25 European Union countries, Bulgaria, Romania, Norway and Switzerland using the WHO checklist for influenza epidemic preparedness (WHO).  WHO/CDS/CSR/GIP/2005.4 Geneva.World Health Organization, 2005.

The results were based on 21 national plans that were eligible by inclusion criteria; these represented 93% of the population reviewed.

The highest scores were for: France, Germany, Ireland, Netherlands, Sweden, Switzerland and the UK.  Review of the plans indicated that attack rates were estimated at 15-50%, anticipated mortality was usually estimated at 230-465/100,000, hospital admissions were projected at 40-2,770/100,000, the coordinating body was always the Ministry of Health and the most common legal issues included were: quarantine, compulsory vs. voluntary vaccination and liability for adverse reactions related to the vaccine.

Public health issues dealt with surveillance plans, availability of an in-country lab, restricted travel, public gatherings and school closures and quarantine. Most of the plans dealt with these issues including at least 15 for each of the designated categories among the 21 plans reviewed.

For medical management, antivirals were recommended by all plans for treatment and by 18/21 plans for prophylaxis. The highest priority for both antivirals and vaccine administration were health care workers for the majority of the plans. A summary of these plans is provided in the following tabulation:

 Predictions and administration 
    Attack rates15-50%
    Death rates (/100,000)14-1685
       Most (/100,000)230-465
    Hospital admissions (/100,000)40-2707
    Usual coordinating bodyMinistry of Health
    Most common legal issueQuarantine, compulsory vaccine & vaccine ADR
 Public health 
    Lead role of public health agency for planning21/21
    Surveillance plan21/21
    WHO-approved in-country lab19/21
    Link to animal surveillance17/21
    School closures expected19/21
    Restricted public gatherings17/21
    Quarantine-voluntary9
        Possibly mandatory14
    Travel restrictions - international15
  
 Medical management 
    Recommend antivirals for treatment21
    Recommend antivirals for prophylaxis18
    Priorities for antivirals-defined16
       Top priority-health care workers11/16
       High risk groups4/16
   Immunization-entire population14/20
       Top priority-health care workers15/20
       Second priority-essential workers12/20
       Third priority-person at risk for serious    complications11/20

Conclusions: The authors conclude that there is “strong” governmental commitment in most European countries for pandemic influenza preparedness.

Comment: The data reviewed appear to show that Europe is substantially ahead of the US in virtually every category.  In large part, this is related to the fact that in the US much of the planning reviewed is relegated to states and major metropolitan areas. Problems at this level are that response has been slow and poorly funded.  Further, in Europe, the great majority of health care is managed by national plans that have ownership and control.  By contrast, the US system of health care is largely private, independent, financially distressed and poorly coordinated for any integrated response to a health care crisis.

Literature Review by John G. Barlett, M.D. Professor, Division of Infectious Diseases

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