Center for Global Health Faculty

Director, Drug Development Unit

Academic Degrees

Departmental Address

Contact Information

Email:

cwhendrix+jhmi.edu

Phone:

410-955-9707

Fax:

410-955-9708

Link:

Personal Website

Link:

SciVal Experts Research Profile

Research and Professional Experience

Dr. Hendrix's primary research focus is chemoprevention of HIV infection. This involves 3 related areas of research: topical HIV microbicide development; pre-exposure prophylaxis of HIV; pharmacology of anti-HIV drugs in the male genital tract.

Microbicde interests include development of methods t ostudy the distrinution of microbicides and HIV in the distal colon and the female genital tract using radiology techniques and direct sampling of the sexually receptive areas. Currently, he is principal investigator of an upcoming NIH-funded, Microbicide Trials Network study (MTN-002) at 6 sites in Africa and the US comparing oral and vaginal antiretroviral strategies to prevent HIV infection.

His current pre-exposure prophylaxis (PrEP) work includes acting a principal investigator of a CDC-funded pharmacology sub-study evaluating the antiretroviral drugs, tenofovir and emtricitabine, dosed orally to prevent HIV infection in an at-risk heterosexual cohort and injection drug use cohort in Botswana and Thailand, respectively.

Keywords

HIV chemoprevention PrEP clinical pharmacology microbicides

Honors and Awards

Johns Hopkins Alumni Association Excellence in Teaching Award, 2003

David M. Levine Faculty Mentoring Award (Department of Medicine) 2007

Selected Publications

Caffo B, Crainiceanu C, Deng L, Hendrix CW. A Case Study in Pharmacologic Imaging Using Principal Curves in Single Photon Emission Computed Tomography. J American Statistical Assoc 2008 (Accepted)

Hendrix CW, Cao YJ, Fuchs EJ. Topical Microbicides to Prevent HIV: Clinical Drug Development Challenges. Ann Rev Pharmacol Toxicol 2009 ; 49:349–75.

Magill SS, Swoboda SM, Shields CE, Johnson EA, Fothergill AW, Merz WG, Lipsett PA, Hendrix CW. The epidemiology of Candida colonization and invasive candidiasis in critically ill surgical patients before and after implementation of routine fluconazole prophylaxis. Ann Surg 2009;249(4):657-665.

Nyunt M, Hendrix CW, Bakshi R, Kumar N, Shapiro TA. Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with plasmodium falciparum sporozoites. Am J Trop Med Hyg 2009 Apr;80(4):528-35.

Cao YJ, Flexner C, Dunaway S, Park JG, Klingman K, Wiggins I, Conley J, Radebaugh C, Kashuba AD, MacFarland R, Becker S, Hendrix CW. Effect of Low-dose Ritonavir on the Pharmacokinetics of the CXCR4 Antagonist AMD070 in Healthy Volunteers. Antimicrob Agents Chemother 2008 May;52(5):1630-4. Epub 2008 Feb 19.

Cao YJ, Smith PF, Wire MB, Lou Y, Lancaster CT, Causon RC, Bigelow G, Martinez E, Fuchs EJ, McCabe S, Hendrix CW. Pharmacokinetics and Pharmacodynamics of Methadone Enantiomers Following Coadministration with Fosamprenavir and Ritonavir in Opioid-Dependent Subjects. Pharmacotherapy 2008 Jul;28(7):863-74.

Nyunt M, Becker S, MacFarland R, Everts S, Chee P, Scarborough R, Hendrix CW. Pharmacokinetic Interaction between AMD11070 and Substrates of CYP3A4 and 2D6 Enzymes in Healthy Volunteers. JAIDS 2008 Apr 15;47(5):559-565.

Cao YJ, Caffo B, Choi L, Radebaugh C, Fuchs EJ, Hendrix CW. Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin. J Clin Pharmacol. 2008 Feb;48(2):176-83. Epub 2007 Dec 19.

Cao Y-J, Hendrix CW. Male Genital Tract Pharmacology: Developments in Quantitative Methods to Better Understand a Complex Peripheral Compartment. Clin Pharmacol Ther . 2008 Mar;83(3):401-12. Epub 2007 Oct 5.

Cao YJ, Ndovi TT, Parsons TL, Guidos A, Caffo B, Hendrix CW. Effect of semen sampling frequency on seminal antiretroviral drug concentration. Clin Pharmacol Ther. 2008 Jun;83(6):848-56. Epub 2007 Oct 3.

Choi L, Caffo BS, Rohde C, Ndovi TT, Hendrix CW. A Mechanistic Latent Variable Model for Estimating Drug Concentrations in the Male Genital Tract: A Case Study in Drug Kinetics. Stat Med 2008 Jun 30;27(14):2697-714.

Ndovi TT, Cao YJ, Fuchs EJ, Fletcher CV, Guidos A, Hendrix CW. Food affects zidovudine concentration independent of effects on gastrointestinal absorption. J Clin Pharmacol 2007;47(11):1366-73.

Pham P, Hendrix CW, Barditch-Crovo P, Parsons T , Khan W, Parrish M, Radebaugh C, Carson KA, Pakes GE, Qaquish R, Flexner C. Amprenavir and lopinavir pharmacokinetics following coadministration of amprenavir or fosamprenavir with lopinavir/ritonavir, with or without efavirenz. Antivir Ther 2007;12(6):963-9.

Hendrix CW, Fuchs EJ, Macura KJ, Lee LA, Parsons TL, Bakshi RP, Khan WA, Guidos A, Leal JP, Wahl R. Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates. Clin Pharmacol Ther 2008 Jan;83(1):97-105. Epub 2007 May 16.

Stone, ND, Dunaway, SB, Flexner, CW, Tierney, C, Calandra, GB, Becker, S, Cao, Y, Wiggins, IP, Conley, J, MacFarland, RT, Park, J, Lalama, C, Snyder, S, Kallungal, B, Klingman, K, Hendrix, CW. Multiple Dose Escalation Study of the Safety, Pharmacokinetics, and Biologic Activity of Oral AMD070, a selective CXCR4 Receptor Inhibitor, in Human Subjects (ACTG A5191). Antimicrob Agents Chemother 2007;51(7):2351-8.

Fuchs EJ, Lee LA, Torbenson MS, Parsons TL, Bakshi RP, Guidos AM, Wahl RL, Hendrix CW. Hyperosmolar Sexual Lubricant Causes Epithelial Damage in the Distal Colon: Potential Implication for HIV Transmission. J Infect Dis 2007;195(5):703-710.

Ndovi TT, Parsons T, Choi L, Caffo B, Rohde C, Hendrix CW. A New Method to Quantitatively Estimate Seminal Vesicle and Prostate Gland Contributions to Ejaculate. Br J Clin Pharmacol 2007;63(4):404-20.

Ndovi TT, Choi L, Caffo B, Parsons T, Baker S, Zhao M, Rohde C, Hendrix CW. Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a non-invasive method. Clin Pharmacol Ther 2006;80(2):146-158.

Magill SS, Swoboda S, Johnson E, Merz WG, Pelz RK, Lipsett PA, Hendrix CW. The impact of anatomical site of Candida colonization on the development of invasive candidiasis and mortality in critically ill surgical patients. Diagn Microbiol Infect Dis 2006;55(4):293-301.

Mayer KH, Maslankowski L, Gai F, El-Sadr W, Justman J, Kwiecien A, Masse B, Eshleman S, Hendrix CW, Morrow K, Absalon J, Rooney J, Soto-Torres L. Tenofovir vaginal gel: Safety and tolerability in low-risk HIV-uninfected women and HIV-infected women (HPTN 050). AIDS 2006;20(4):543-551.