Center for Global Health Faculty

Professor

Director, Johns Hopkins Center for Global Health

Academic Degrees

• MD
• MS

Departmental Affiliation

• Name:

  International Health

  Affiliation Type:

  Primary

  Division:

  Infectious Diseases

Departmental Address

Contact Information

Email:

tquinn+jhmi.edu

Phone:

410-955-7635

Fax:

410-614-9775

Research and Professional Experience

Investigation of the epidemiology, pathogenesis, and clinical features of HIV/AIDS internationally. Interaction between STDs and tropical diseases on the natural history and spread of HIV/AIDS in developing countries. Recent research has examined the viral kinetics and transmission probabilities of HIV among discordant couples with the subsequent design and application of interventions including therapy to prevent transmission of HIV. Molecular studies have mapped the molecular epidemic of HIV on a global basis, linking virologic changes to the spread of HIV and measuring the demographic impact of the epidemic. Implementation of clinical care programs for HIV, STDs, and other infectious diseases while advocating for improved clinical education for African physicians and implementing public health policy from these and other research findings.

He serves as advisor/consultant on HIV and STDs to the World Health Organization, Office of the Global AIDS Coordinator (PEPFAR), UNAIDS, and the U.S. Food and Drug Administration.   In 2004 he became a member of the Institute of Medicine of the National Academy of Science. He is a founding member of the Academic Alliance for AIDS Care and Prevention in Africa; founding director of the Johns Hopkins Center for Global Health.He is an author of approximately 900 publications on HIV, STDs, and infectious diseases.

Keywords

HIV, AIDS, STDs, STI, epidemiology, global health, infectious diseases, pathogenesis, viral infections, chlamydia, developing countries, resource-limited settings

Honors and Awards

1969-72 U.S.P.H.S. Research Training Award from NIAID, NIH 1970-74 Northwestern Univ Medical School Health Professions Award 1979-81 U.S.P.H.S. Career Development Award 1980 U.S.P.H.S. Special Assignment Award 1985 U.S.P.H.S. Commendation Award, NIAID, NIH 1987 A.O.A. Epidemiology Research Award 1987 State of Maryland Annual Distinguished Physician Lectureship 1988 U.S.P.H.S. Outstanding Service Award, NIAID, NIH 1989 U.S.P.H.S. Outstanding Unit Citation, NIAID, NIH 1990 UCLA Lester Breslow Distinguished Lectureship Epidemiology 1990 UCLA John F. Kessel Distinguished Lectureship Tropical Med 1990 University of Florida Commemorative Award Presentation 1994 Charles C. Shepard Award Outstanding Scientific Publication 1994 National Center for Infectious Diseases, Centers for Disease Control and Prevention Special Recognition Award 1994 James H. Nakano Citation Outstanding Scientific Publication 1995 American College of Preventive Medicine Award for Best Scientific Presentation 1995 U.S.P.H.S. Meritorious Service Award 1996 Stephen Gross HIV Lectureship Award, Cedars-Sinai Hospital 1996 U.S.P.H.S. Meritorious Service Award, NIAID, NIH 1996-99 Best Doctors in America, Infectious Diseases, HIV and STDs 1998 Special Opening Plenary Lecture, IDSA 1998 U.S.P.H.S. Bicentennial Unit Commendation 1999 ASTDA Lifetime Achievement Award 1999 Indiana Univ School of Medicine Award in Infectious Diseases 1999 U.S.P.H.S. Distinguished Service Award 2000 Duncan Catterall Memorial Lecture, British Association for Sexual Health and HIV 2000 Sommer Memorial Lecture, Portland, Oregon 2000 U.S.P.H.S. Distinguished Service Award 2000 IAPAC Heroes in Medicine Award 2002 Dowling Memorial Visiting Professorship, University of Illinois Medical Ctr 2003 Harold C. Neu Visiting Professorship, Columbia University 2003 Harry C. Dascomb Memorial Visiting Scholar Lectureship, Louisiana State University 2003 Plenary Lectdureship, 12th Annual Canadian Conference on HIV/AIDS Research, Nova Scotia, Canada 2004 Morris M. Gollow Keynote Lectureship, Australasian Sexual Health Conference 2004 Elected Member, Institute of Medicine, National Academy of Sciences 2007 Elected Fellow, American Association for the Advancement of Science, 2007 John F. Ender Lecture, IDSA, 2007 NIAID Special Act or Service Award for Coordinating International Research Activities, 2007 Massachusetts General Hospital David Brudnoy Visiting Professorship, 2008 Elected to Fellow of the American Association for Advancement in Science, 2008 FDA Office of Women’s Health, Certificate of Appreciation, 2009 Distinguished Visiting Lectureship Award, University of Manitoba, 2009 Distinguished Visiting Professor in Global Health, Duke University, 2010 ACP Maryland Chapter Mary Betty Stevens Award for Clinical Research, 2010 Ed Nowakowski Senior Memorial Clinical Virology Award, 2011The Thomas Parran Award of the American Sexually Transmitted Diseases Association, 2011Benjamin Keane Lecture, Weill Cornell School of Medicine, 2012 University of Notre Dame Distinguished Alumnus Award and 2012 Commencment Speaker for the University of Notre Dame Graduate School

Selected Publications

Quinn TC, Serwadda D. The future of HIV/AIDS in Africa: a shared responsibility. Lancet 2011;377:1133-1134.

Aumakhan B, Hardick A, Quinn TC, Laeyendecker O, Gange SJ, Beyrer C, Cox C, Anastos K, Cohen M, Greenblatt RM, Merenstein DJ, Minkoff H, Nowicki M, Gaydos CA. Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data. Virol J. 2010 Nov 18;7:328.

 Chang LW, Kagaayi J, Nakigozi G, Ssempijja V, Packer AH, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ. Effect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomized trial. PLoS One. 2010 Jun 2;5(6):e10923.

 Redd AD, Eaton KP, Kong X, Laeyendecker O, Lutalo T, Wawer MJ, Gray RH, Serwadda D, Quinn TC; Rakai Health Sciences Program. C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation. J Acquir Immune Defic Syndr. 2010 Aug 15;54(5):556-9.

 Quinn TC, Samet JM. Epidemiologic approaches to global health. Epidemiol Rev. 2010 Apr;32(1):1-4. Epub 2010 Jun 25.

 Tang S, Zhao J, Viswanath R, Myambi PN, Vermeulen M, Redd AD, Dastyar A, Spacek LA, Quinn TC, Wang X, Wood O, Gaddam D, Hewlett IK.  Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus type one (HIV-1) infected individuals in Cameroon, South Africa, and Uganda. Transfusion 2011:51:463-468.

Johnson KE, Redd AD, Quinn TC, Collinson-Streng A, Cornish T, Kong X, Sharma R, Tobian AAR, Tsai B, Sherman ME, Kigozi G, Serwadda D, Wawer MJ, Gray RH.  Effects of HIV-1 and HSV type 2 infection on lymphocyte and dendritic cell density in adult foreskins from Rakai, Uganda. J Infect Dis 2011; 203:602-9.

 Ng OT, Munshaw S, Lamers SL, Chew KK, Lin L, Redd AD, Manucci J, Quinn TC, Ray SC, Chua A, Leo YS, Laeyendecker O. Molecular Epidemiology of HIV Type 1 in Singapore and Identification of Novel CRF01_AE/B Recombinant Forms. AIDS Res Hum Retroviruses. 2011 Feb 14. [Epub ahead of print]

 Redd AD, Gray RH, Quinn TC. Is Microbial Translocation a Cause or Consequence of HIV Disease Progression? J Infect Dis. 2011 Mar;203(5):744-5. Epub 2011 Jan 10.

 Wawer MJ, Tobian AAR, Kogozi G, Kong X, Gravitt PE, Serwadda D, Nalugoda F, Makumbi F, Ssempiija V, Sewankambo N, Watya S, Eaton KP, Oliver AE, Chen MZ, Reynolds SJ, Quinn TC, Gray RH for the Rakai Health Sciences Program.  Male circumcision reduces human papillomavirus transmission to HIV-negative female partners: a randomized trial in Rakai, Uganda. Lancet 2011 Jan. 6.

 Reynolds SJ, Makumbi F, Nakigozi G, Kagaayi J, Gray RH, Wawer M, Quinn TC, Serwadda D. HIV-1 transmission among HIV-1 discordant couples before and after the introduction of antiretroviral therapy. AIDS. 2011 Feb 20;25(4):473-7.

 Wawer MJ, Gray RH, Serwadda D, Kigozi G, Nalugoda F, Quinn TC. Male circumcision as a component of human immunodeficiency virus prevention. Am J Prev Med. 2011 Mar;40(3):e7-8.

 Tobian AAR, Kong X, Wawer MJ, Kigozi G, Gravitt PE, Serwadda D, Eaton KP, Nalugoda F, Quinn TC, Gray RH. The effect of circumcision of HIV-infected men on human papillomavirus infection in female partners: analyses using data from a randomized trial in Rakai, Uganda.  Lancet Infect Dis, in press.

 Redd AD, Collinson-Streng A, Martens C, Ricklefs S, Mullis CE, Manucci J, Tobian AAR, Selig EJ, Laeyendecker O, Sewankambo N, Gray RH, Serwadda D, Wawer MJ, Porcella SF, Quinn TC.  Identification of HIV superinfection in seroconcordant couples 1 in Rakai, Uganda using next generation deep sequencing. J Clin Microbiol 2011;49:2859-2867.

 Stabinski L, Reynolds S, Ocama P, Laeyendecker O, Kiggundu V, Boaz I, Ndyanabo A, Thomas D, Gray R, Wawer M, Quinn, T, Kirk, G. High Prevalence of Liver Fibrosis Associated with HIV Infection: A Study in Rural Rakai, Uganda. Antiviral Therapy 2011;16:405-411.

Neal JD, Tobian AAR, Laeyendecker O, Ngo TD, Redd AD, Reynolds SJ,  Morrow RA,  Gamiel JL, Serwadda D, Gray RH, and Quinn TC.  Performance of Euroline Western Blot Assay in the Detection of Herpes Simplex Virus type 2 Antibody in Uganda, China, and the United States. Int J STD AIDS, 2011;22:342-344.

 Xing S, Bullen CK, Shroff NS, Shan L, Yang H-C, Manucci JL, Bhat S, Quinn TC, Margolis DM, Siliciano JD, Siliciano RF.  Disulfiram reactivates latent HIV-1 in a Bcl-2 transduced primary CD4+ T-cell model without inducing global T-cell activation.  J Virol 2011;85:6060-6064.

 Quinn TC. Viral kinetics of genital herpes: a molecular probe into host-viral interactions. Editorial. Journal of Infectious Diseases 2011;204:495-498.

Incidence Assay Critical Path Working Group (Thomas C. Quinn, member).  More and beter information to tackle HIV epidemics: towards improved HIV incidence assays. PLoS Medicine 2011;8:e1001045.

 Rotheram-Borus MJ, Wu Z, Liang L-J, Li L, Detels R, Guan J, Yin Y, Swendeman D, NIMH Collaborative HIV/STD Preention Trial Group (Thomas C. Quinn, Core Laboratory).  Reductions in sexually transmitted infections associated with popular opinion leaders in China in a randomized controlled trial.  Sex Transm Infect 2011;87:337-343. 

 Arem H, Nakyanjo N, Kagaayi J, Mulamba J, Nakogozi G, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ, Chang LW.  Peer health workers and AIDS care in Rakai, Uganda: a mixed methods operations research evaluation of a cluster-randomized trial.  AIDS Patient Care 2011; 25:719-724.

West SK, Munoz B, Mkocha H, Gaydos CA, Quinn TC.  Number of years of annual mass treatment with azithromycin needed to control trachoma in hyper-endemic communities in Tanzania.  J Infect Dis 2011;204:268-273.

Chang LW, Kagaayi J, Arem H, Nakigozi G, Ssempijja V, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ. Impact of a mHealth intervention for peer health workers on AIDS care in rural Uganda: a mixed methods evaluation of a cluster-randomized trial. AIDS and Behavior 2011;15:1776-1784.

 Quinn TC. The Thomas Parran Award Lecture 2011. The 30-year war on AIDS: Have we reached the tipping point? Sex Transm Dis 2011;38:1089-1093.

Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Mehendale S, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Wang L, Makhema J, Mills LA, de Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Burns D, Taha TE, Nielsen-Saines K, Celentano D, Essex M, Fleming TR; HPTN 052 Study Team (Thomas C. Quinn, Core Laboratory). Prevention of HIV-1 infection with early antiretroviral therapy. N Eng J Med 365:493-505, 2011.

Tobian AAR, KIgozi G, Redd AD, Serwadda D, Kong X, Oliver A, Nalugoda F, Quinn TC, Gray RH, Wawer MJ.  Male circumcision and herpes simplex virus type 2 infection in female partners:  a randomized trial in Rakai, Uganda. J Infect Dis 2012;205:486-490.

Redd AD, Laeyendecker O, Kong X, Kiwanuka N, Lutalo T, Huang W, Gray RH, Wawer MJ, Serwadda D, Eshleman SH, Quinn TC.  Changes in HIV-1 CCR5 replication efficiency and its effects on disease progression in Rakai district, Uganda.  AIDS Res Hum Retrovir 2012;28:289-294.

Tobian AAR, Kong X, Gravitt PE, Eaton KP, Kogozi G, Serwadda D, Oliver AE, Nalugoda F, Makumbi F, Chen MZ, Wawer MJ, Quinn TC, Gray RH.  Male circumcision and anatomic sites of penile human papillomavirus in Rakai, Uganda. Int J Cancer 2011;129:2970-2975.

Gaydos CA, Rizzo-Price PA, Pachamutha B, Mateta P, Leon SR, Verevochkin S, Yue-ping Y, Quinn TC, Strader LC, Pequegnat W, the NIMH Collaborative HIV/STD Prevention Trial Group.  Impact of international laboratory partnerships on the performance of HIV/STD testing in five resource-constrained countries.  Int J STD AIDS 2011;22:645-652.

 Stabinski L, Reynolds S, Ocama P, Laeyendecker O, Serwadda D, Thomas D, Gray R, Wawer M, Quinn, T, Kirk, G. HBV and Sexual Behavior in Rakai, Uganda. J Med Virol 2011;83:796-800.

 Eller MA, Blom KG, Gonzalez VD, Eller LA, Naluyima P, Laeyendecker O, Quinn TC, Kiwanuka N, Serwadda D, Sewankambo NK, Tasseneetrithep B, Wawer MJ, Gray RH, Marovich MA, Michael NL, de Souza MS, Wabwire-Mangen F, Robb ML, Currier JR, Sandberg JK.  CD38, HLA-DR, and PD-1 together define pathogenic CD4 T-cell immune activationin chronic HIV-1 infection. PLoS 2011 6(4):e18779.

 Tobian AAR, Kigozi G, Gravitt PE, Xiao CC, Serwadda D, Eaton KP, Kong X, Wawer M, Nalugoda F, Quinn TC, Gray RH. Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in Rakai, Uganda. AIDS 2012 Mar 21, epub.

 Mullis CE, Oliver AE, Eller LA, Guwatudda D, Mueller AC, Eller MA, Kibuuka H, Robb M, Quinn TC, Redd AD.  Colony-forming hematopoietic progenitor cells are not preferentially infected by HIV-1 subtypes A and D in vivo. AIDS Res Hum Retrovir 2012 Feb 2, epub.

 Reynolds SJ, Makumbi F, Newell K, Kiwanuka N, Ssebbowa P, Mundo G, Boaz I, Wawer MJ, Gray RH, Serwadda D, Quinn TC. Daily acyclovir to prevent disease progression among HIV-1/HSV-2 co-infected individuals: a randomized, double-blinded placebo-controlled trial in Rakai, Uganda. Lancet Infect Dis 2012;12:441-448.

Redd AD, Mullis CE, Serwadda D, Kong X, Martens C, Ricklefs SM, Tobian AA, Xiao C, Grabowski MK, Nalugoda F, Kigozi G, Laeyendecker O, Kagaayi J, Sewankamb O N, Gray RH, Porcella SF, Wawer MJ, Quinn TC. The Rates of HIV Superinfection and Primary HIV Incidence in a General Population in Rakai, Uganda. J Infect Dis. 2012 Jun 5. [Epub ahead of print]

Tobian AA, Grabowski MK, Kigozi G, Gravitt PE, Eaton KP, Serwadda D, Nalugoda F, Wawer MJ, Quinn TC, Gray RH. High-risk human papillomavirus prevalence is associated with HIV infection among heterosexual men in Rakai, Uganda. Sex Transm Infect. 2012 May 24. [Epub ahead of print]

 Bisono GM, Simmons L, Volk RJ, Meyer D, Quinn TC, Rosenthal SL. Attitudes and Decision Making About Neonatal Male Circumcision in a Hispanic Population in New York City. Clin Pediatr (Phila). 2012 Apr 17. [Epub ahead of print]

 Reynolds SJ, Laeyendecker O, Nakigozi G, Gallant JE, Huang W, Hudelson SE, Quinn TC, Newell K, Serwadda D, Gray RH, Wawer MJ, Eshleman SH. Antiretroviral Drug Susceptibility Among HIV-Infected Adults Failing Antiretroviral Therapy in Rakai, Uganda. AIDS Res Hum Retroviruses. 2012 Apr 26. [Epub ahead of print]

 Tobian AA, Kigozi G, Gravitt PE, Xiao C, Serwadda D, Eaton KP, Kong X, Wawer MJ, Nalugoda F, Quinn TC, Gray RH. Human papillomavirus incidence and clearance among HIV-positive and HIV-negative men in Rakai, Uganda. AIDS. 2012 Mar 23. [Epub ahead of print]

 Reynolds SJ, Makumbi F, Newell K, Kiwanuka N, Ssebbowa P, Mondo G, Boaz I, Wawer MJ, Gray RH, Serwadda D, Quinn TC. Effect of daily acyclovir on HIV disease progression in individuals in Rakai, Uganda, co-infected with HIV-1 and herpes simplex virus type 2: a randomised, double-blind placebo-controlled trial. Lancet Infect Dis. 2012 Jun;12(6):441-8. Epub 2012 Mar 19.

 Laeyendecker O, Brookmeyer R, Mullis C, Donnell D, Lingappa J, Celum C, Baeten JM, Campbell MS, Essex M, de Bruyn G, Farquhar C, Quinn TC, Eshleman S. Specificity of four laboratory approaches for cross-sectional HIV incidence determination: Analysis of samples from adults with known non-recent HIV infection from five African countries. AIDS Res Hum Retroviruses. 2012 Jan 29. [Epub ahead of print]

 Tobian AA, Kigozi G, Redd AD, Serwadda D, Kong X, Oliver A, Nalugoda F, Quinn TC, Gray RH, Wawer MJ. Male circumcision and herpes simplex virus type 2 infection in female partners: a randomized trial in Rakai, Uganda. J Infect Dis. 2012 Feb 1;205(3):486-90. Epub 2011 Dec 5.

 Cousins MM, Laeyendecker O, Beauchamp G, Brookmeyer R, Towler WI, Hudelson SE, Khaki L, Koblin B, Chesney M, Moore RD, Kelen GD, Coates T, Celum C, Buchbinder SP, Seage GR 3rd, Quinn TC, Donnell D, Eshleman SH. Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infection. PLoS One. 2011;6(11):e27211. Epub 2011 Nov 2.