Center for Global Health Faculty

Professor

Director, Johns Hopkins Center for Global Health

Academic Degrees

• MD
• MS

Departmental Affiliation

• Name:

  International Health

  Affiliation Type:

  Primary

  Division:

  Infectious Diseases

Departmental Address

Contact Information

Email:

tquinn+jhmi.edu

Phone:

410-955-7635

Fax:

410-614-9775

Research and Professional Experience

Investigation of the epidemiology, pathogenesis, and clinical features of HIV/AIDS internationally. Interaction between STDs and tropical diseases on the natural history and spread of HIV/AIDS in developing countries. Recent research has examined the viral kinetics and transmission probabilities of HIV among discordant couples with the subsequent design and application of interventions including therapy to prevent transmission of HIV. Molecular studies have mapped the molecular epidemic of HIV on a global basis, linking virologic changes to the spread of HIV and measuring the demographic impact of the epidemic. Implementation of clinical care programs for HIV, STDs, and other infectious diseases while advocating for improved clinical education for African physicians and implementing public health policy from these and other research findings.

Dr. Quinn was one of the first to demonstrate that non-invasive screening for STDs by use of molecular diagnostic assays could extend public health efforts to control STDs to non-clinic settings. This innovative approach, when coupled with his findings on the role of STDs as co-factors in enhancing HIV transmission, has led to one of the current basic tenets of the global AIDS control program; the treatment of STDs to slow the transmission of HIV. Currently directs several field-based programs in Africa and Asia, utilizing community-based STD treatment linked with HIV prevention projects. Founding member of the Academic Alliance for AIDS Care and Prevention in Africa; founding director of the Johns Hopkins Center for Global Health.

Keywords

HIV, AIDS, STDs, STI, epidemiology, global health, infectious diseases, pathogenesis, viral infections, chlamydia, developing countries, resource-limited settings

Honors and Awards

1969-72 U.S.P.H.S. Research Training Award from NIAID, NIH 1970-74 Northwestern Univ Medical School Health Professions Award 1979-81 U.S.P.H.S. Career Development Award 1980 U.S.P.H.S. Special Assignment Award 1985 U.S.P.H.S. Commendation Award, NIAID, NIH 1987 A.O.A. Epidemiology Research Award 1987 State of Maryland Annual Distinguished Physician Lectureship 1988 U.S.P.H.S. Outstanding Service Award, NIAID, NIH 1989 U.S.P.H.S. Outstanding Unit Citation, NIAID, NIH 1990 UCLA Lester Breslow Distinguished Lectureship Epidemiology 1990 UCLA John F. Kessel Distinguished Lectureship Tropical Med 1990 University of Florida Commemorative Award Presentation 1994 Charles C. Shepard Award Outstanding Scientific Publication 1994 National Center for Infectious Diseases, Centers for Disease Control and Prevention Special Recognition Award 1994 James H. Nakano Citation Outstanding Scientific Publication 1995 American College of Preventive Medicine Award for Best Scientific Presentation 1995 U.S.P.H.S. Meritorious Service Award 1996 Stephen Gross HIV Lectureship Award, Cedars-Sinai Hospital 1996 U.S.P.H.S. Meritorious Service Award, NIAID, NIH 1996-99 Best Doctors in America, Infectious Diseases, HIV and STDs 1998 Special Opening Plenary Lecture, IDSA 1998 U.S.P.H.S. Bicentennial Unit Commendation 1999 ASTDA Lifetime Achievement Award 1999 Indiana Univ School of Medicine Award in Infectious Diseases 1999 U.S.P.H.S. Distinguished Service Award 2000 Duncan Catterall Memorial Lecture, British Association for Sexual Health and HIV 2000 Sommer Memorial Lecture, Portland, Oregon 2000 U.S.P.H.S. Distinguished Service Award 2000 IAPAC Heroes in Medicine Award 2002 Dowling Memorial Visiting Professorship, University of Illinois Medical Ctr 2003 Harold C. Neu Visiting Professorship, Columbia University 2003 Harry C. Dascomb Memorial Visiting Scholar Lectureship, Louisiana State University 2003 Plenary Lectdureship, 12th Annual Canadian Conference on HIV/AIDS Research, Nova Scotia, Canada 2004 Morris M. Gollow Keynote Lectureship, Australasian Sexual Health Conference 2004 Elected Member, Institute of Medicine, National Academy of Sciences 2007 Elected Fellow, American Association for the Advancement of Science

Selected Publications

Kamya MR, Mayanja-Kizza H, Kambugu A, Bakeera-Kitaka S, Semitala F, Mwebaze-Songa P, Castelnuovo B, Schaefer P, Spacek LA, Gasasira AF, Katabira E, Colebunders R, Quinn TC, Ronald A, Thomas DL, Kekitiinwa A, Academic Alliance for AIDS Care and Prevention in Africa (2007) Predictors of long-term viral failure among ugandan children and adults treated with antiretroviral therapy. J Acquir Immune Defic Syndr 46:187-93.

Kagaayi J, Makumbi F, Nakigozi G, Wawer MJ, Gray RH, Serwadda D, Reynolds SJ (2007) WHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda. AIDS 21:1208-10. [PubMed]

Oyugi JH, Byakika-Tusiime J, Ragland K, Laeyendecker O, Mugerwa R, Kityo C, Mugyenyi P, Quinn TC, Bangsberg DR (2007) Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, Uganda. AIDS 21:965-71.

Quinn TC (2007) Circumcision and HIV transmission. Curr Opin Infect Dis 20:33-8.

Moss WJ, Scott S, Mugala N, Ndhlovu Z, Beeler JA, Audet SA, Ngala M, Mwangala S, Nkonga-Mwangilwa C, Ryon JJ, Monze M, Kasolo F, Quinn TC, Cousens S, Griffin DE, Cutts FT (2007) Immunogenicity of standard-titer measles vaccinein HIV-1-infected and uninfected Zambian children: an observational study. J Infect Dis 196:347-55.

Gray RH, Makumbi F, Serwadda D, Lutalo T, Nalugoda F, Opendi P, Kigozi G, Reynolds SJ, Sewankambo NK, Wawer MJ (2007) Limitations of rapid HIV-1 tests during screening for trials in Uganda: diagnostic test accuracy study. BMJ 335:188.

Gray RH, Li X, Kigozi G, Serwadda D, Nalugoda F, Watya S, Reynolds SJ, Wawer M (2007) The impact of male circumcision on HIV incidence and cost per infection prevented: a stochastic simulation model from Rakai, Uganda. AIDS 21:845-50. [PubMed]

Gray RH, Kigozi G, Serwadda D, Makumbi F, Watya S, Nalugoda F, Kiwanuka N, Moulton LH, Chaudhary MA, Chen MZ, Sewankambo NK, Wabwire-Mangen F, Bacon MC, Williams CF, Opendi P, Reynolds SJ, Laeyendecker O, Quinn TC, Wawer MJ (2007) Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 369:657-66.

Calmy A, Ford N, Hirschel B, Reynolds SJ, Lynen L, Goemaere E, Garcia de la Vega F, Perrin L, Rodriguez W (2007) HIV viral load monitoring in resource-limited regions: optional or necessary? Clin Infect Dis 44:128-34.

Blake DR, Quinn TC, Gaydos CA (2008) Should asymptomatic men be included in chlamydia screening programs? Cost-effectiveness of chlamydia screening among male and female entrants to a national job training program. Sex Transm Dis 35:91-101.

Chang LW, Kagaayi J, Nakigozi G, Packer AH, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ (2008) Responding to the human resource crisis: peer health workers, mobile phones, and HIV care in Rakai, Uganda. AIDS Patient Care STDS 22:173-4.

Gamiel JL, Tobian AA, Laeyendecker OB, Reynolds SJ, Morrow RA, Serwadda D, Gray RH, Quinn TC (2008) Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda. Clin Vaccine Immunol 15:888-90.

Kiwanuka N, Laeyendecker O, Robb M, Kigozi G, Arroyo M, McCutchan F, Eller LA, Eller M, Makumbi F, Birx D, Wabwire-Mangen F, Serwadda D, Sewankambo NK, Quinn TC, Wawer M, Gray R (2008) Effect of human immunodeficiency virus Type 1 (HIV-1) subtype on disease progression in persons from Rakai, Uganda, with incident HIV-1 infection. J Infect Dis 197:707-13.

Moss WJ, Fisher C, Scott S, Monze M, Ryon JJ, Quinn TC, Griffin DE, Cutts FT (2008) HIV type 1 infection is a risk factor for mortality in hospitalized Zambian children with measles. Clin Infect Dis 46:523-7.

Ngo TD, Laeyendecker O, La H, Hogrefe W, Morrow RA, Quinn TC (2008) Use of commercial enzyme immunoassays to detect antibodies to the herpes simplex virus type 2 glycoprotein G in a low-risk population in Hanoi, Vietnam. Clin Vaccine Immunol 15:382-4.

Ngo TD, Laeyendecker O, Morrow RA, Lai S, Quinn TC (2008) Comparison of three commercial immunoassays for detection of herpes simplex virus type 2 antibodies in commercial sex workers in yunnan province, china. Clin Vaccine Immunol 15:1301-3.

Persaud D, Ray SC, Kajdas J, Ahonkhai A, Siberry GK, Ferguson K, Ziemniak C, Quinn TC, Casazza JP, Zeichner S, Gange SJ, Watson DC (2007) Slow human immunodeficiency virus type 1 evolution in viral reservoirs in infants treated with effective antiretroviral therapy. AIDS Res Hum Retroviruses 23:381-90.

Scott S, Moss WJ, Cousens S, Beeler JA, Audet SA, Mugala N, Quinn TC, Griffin DE, Cutts FT (2007) The influence of HIV-1 exposure and infection on levels of passively acquired antibodies to measles virus in Zambian infants. Clin Infect Dis 45:1417-24.

Summerton J, Riedesel M, Laeyendecker O, Gaydos C, Maldeis NE, Hardick A, Morrow RA, Quinn TC (2007) Effect of sexually transmitted disease (STD) coinfections on performance of three commercially available immunosorbent assays used for detection of herpes simplex virus type 2-specific antibody in men attending Baltimore, Maryland, STD clinics. Clin Vaccine Immunol 14:1545-9.

Waters L, Kambugu A, Tibenderana H, Meya D, John L, Mandalia S, Nabankema M, Namugga I, Quinn TC, Gazzard B, Reynolds SJ, Nelson M (2007) Evaluation of filter paper transfer of whole-blood and plasma samples for quantifying HIV RNA in subjects on antiretroviral therapy in Uganda. J Acquir Immune Defic Syndr 46:590-3.