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Center for Global Health Faculty

Simona Stager

Academic Degrees

Departmental Address

BRB Room 655, 733 N. Broadway, Baltimore MD 21205

Contact Information

Phone:
410-502-4424
Link:
Personal Website
Link:
SciVal Experts Research Profile

Keywords

  • Immunology
  • regulation of T-cell responses
  • infectious diseases
  • Leishmania

Selected Publications

Maroof A., Beattie L., Zubairi S., Svensson M., Stäger S., Kaye P.M. (2008) Posttranscriptional regulation of Il10 gene expression allows natural killer cells to express immunoregulatory function. Immunity, 29(2):295-305.

Stäger, S., Maroof, A., Zubairi, S., Sanos, S.L., Kopf, M., and Kaye, P.M. (2006) Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania donovani and the expansion of IL-10+CD4+ T-cells. European Journal of Immunology.

Polley, R.*, Stäger, S.*, Prickett, S., Maroof, A., Zubairi, S., Smith, D.F., and Kaye, P.M. (2006) Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen. Infection and Immunity, 74(1): 773-776.

Engwerda, C.R., Ato, M., Stäger, S., Alexander C., and Kaye, P.M. (2004) Distinct roles for lymphotoxin-alfa and TNFalfa in the control of Leishmania donovani infection. American Journal of Pathology, 165(6):2123-2133.

Stäger, S. and Kaye, P.M. (2004) CD8+ T cell priming regulated by cytokines of the innate immune system. Trends in Molecular Medicine, 10(8): 366-371.

Kaye P.M., Svensson M., Ato M., Maroof A., Polley R., Stäger S., Zubairi S., Engwerda C.R. (2004) The immunopathology of experimental visceral leishmaniasis. Immunological Reviews, 201:239-53.

Stäger, S., Alexander J., Kirby A.C., Botto M., Van Rooijen N., Smith D.F., Brombacher, F., and Kaye, P.M. (2003) Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T cell responses. Nature Medicine, 9(10): 1287-1292.

Stäger, S., Alexander, J., Carter, C.K., Brombacher, F., and Kaye, P.M. (2003) Both IL-4 and IL-4R? signaling contribute to the development of hepatic granulomas with optimal anti-leishmanial activity. Infection and Immunity, 71(8): 4804-4807.

Ato, M., Stäger, S., Engwerda, C.R. and Kaye, P.M. (2002) Defective CCR7-dependent migration of dendritic cells contributes to the development of chronic visceral leishmaniasis. Nature Immunology 3: 1185-1191.

Stäger, S., Smith, D.F., and Kaye, P.M. (2000). Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis. Journal of Immunology, 165: 7064-7071.

Müller, N., Stäger, S. (1999). Periodic appearance of a predominant variant antigen-type during a Giardia lamblia infection in the mouse model. International Journal of Parasitology, 66(4): 1287-1293.

Alce, T.M., Gokool, S., McGhie, D., Stäger, S., Smith, D.F. (1999) Expression of hydrophilic surface proteins in infective stages of Leishmania donovani. Molecular and Biochemical Parasitology, 102: 191-196.

Stäger, S., Gottstein, B., Sager, H., Jungi, T.W., Müller, N. (1998). Giardia lamblia infection in the murine mother/offspring model: influence of milk antibodies on antigenic variation of the parasite. Infection and Immunity, 66(4): 1287-1293.

Stäger, S., Müller, N. (1997). Giardia lamblia infections in B-cell deficient transgenic mice. Infection and Immunity, 65 (9): 3944-3946.

Stäger, S., Gottstein, B., Müller, N. (1997). Systemic and local antibody response in mice induced by recombinant peptide fragment from Giardia lamblia variant surface protein H7 (VSPH7) produced by a Salmonella typhimurium vaccine strain. International Journal of Parasitology, 27 (8): 965-971.

Stäger, S., Felleisen, R., Gottstein, B., Müller, N. (1997). Giardia lamblia variant surface protein (VSP) H7 stimulates a heterogeneous repertoire of antibodies displaying differential cytological effects on the parasite. Molecular and Biochemical Parasitology, 85: 113-124.

Hemphill, A., Stäger, S., Gottstein, B., Müller, N. (1996). Electron microscopical investigation of surface alteration on Giardia lamblia trophozoites after exposure to a cytotoxic monoclonal antibody. Parasitology Research, 82: 206-210.

Müller, N., Stäger, S., Gottstein, B. (1996). Serological analysis of antigenic heterogeneity of Giardia lamblia variant surface proteins. Infection and Immunity, 64 (4): 1385-1390.

      
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