Center for Global Health Faculty
1503 E. Jefferson Street, Room 116
Baltimore, MD 21287
Research and Professional Experience
I am an physician trained in internal medicine, infectious diseases, and epidemiology with an interest in multidisciplinary, innovative, and pragmatic approaches to impacting the HIV/AIDS pandemic. I have 3 main areas of focus in my scholarship and leadership activities.
1. HIV/AIDS Implementation and Operations Research- My main focus is on developing innovative and pragmatic strategies for improving HIV/AIDS care in low- and middle-income settings and performing implementation and operations research to assess impact and implementation challenges. These strategies include involving community health workers to help address the human resource crisis through improving clinical care, improving linkage, engagement, and retention in care, and through integrating HIV prevention and care interventions. I primarily work in Africa, mostly in Uganda with the Rakai Health Sciences Program, and try to bring to this growing and multidisciplinary field of HIV/AIDS Implementation/Operations Research application of quantitative methods, qualitative methods, community-based trial designs, as well as behavioral science and economic evaluations.
2. Global mHealth-A related and growing focus of my research is using novel mHealth (mobile technologies for health) strategies for improving global public health and clinical care, including novel applications for maternal/child health, intimate-partner violence, and HIV care, surveillance, and prevention. I am the Director of Science and Implementation for the Hopkins-based eMOCHA (electronic Mobile Open-source Comprehensive Health Application) mHealth Platform (www.emocha.org), and I oversee active projects involving eMOCHA in Baltimore, Afghanistan, and Uganda. I am a member of the newly formed Steering Committee for a University-wide Johns Hopkins Global mHealth Initiative.
3. HIV/AIDS Systematic Reviews and Guideline Development-I am also actively involved in systematic reviews on topics in HIV as well as on guideline development. I am an active member of the Cochrane HIV/AIDS group. I have been an active member in WHO guideline development for the past 6 years, most recently having a role in the 2010 update of HIV treatment guidelines. I am currently the Methodology Section Head for the development of new global guidelines on adherence and retention sponsored by the International Association of Providers of AIDS Care (IAPAC).
AIDS, HIV, antiretroviral therapy, operational research, mobile phones, information communications technology, ict, smartphones, community health workers, peer health workers, mhealth, ehealth, africa, uganda, implementation research, medical education, online, internet, human resources, world health organization, guidelines, WHO, task shifting, adherence, mixed methods
Aberg JA, Watson J, Segal M, Chang LW. Clinical utility of monitoring serum cryptococcal antigen (sCRAG) titers in patients with AIDS-related cryptococcal disease. HIV Clinical Trials 2000;1:1-6.
Chang LW, Osei-Kwasi M, Boakye D, Aidoo S, Hagy A, Curran JW, Vermund SH. HIV-1 and HIV-2 Seroprevalence and risk factors among hospital outpatients in the Eastern Region of Ghana, West Africa. JAIDS 2002;29:511-516.
Macharia DK, Chang LW, Lule G, Owili DM, Tesfaledet G, Patel S, Silverstein DM, Ng’ang’a L, Bush T, De Cock KM, Weidle PJ. Antiretroviral therapy in the private sector of Nairobi, Kenya: a review of the experience of five physicians. AIDS 2003;17(6):938-940.
Chang LW, Phipps WP, Kennedy GF, Rutherford GW. Antifungal interventions for the primary prevention of cryptococcal disease in adults with HIV. Cochrane Database Syst Rev 2005;Jul 20(3):CD004773.
Chang LW, Kagaayi J, Nakigozi G, Galiwango R, Mulamba J, Ruwangula A, Gray RH, Quinn TC, Bollinger RC, Reynolds SJ. Telecommunications and health care: An HIV/AIDS Warmline for communication and consultation in Rakai, Uganda. J Int Assoc Physicians AIDS Care 2008;7(3):130-132.
Chang LW, Slamo S, Guma S, Christopher J, Suntoke T, Omeste R, Montis J, Quinn T, Juncker M, Reynolds SJ. Two year virologic outcomes of an alternative AIDS care model: evaluation of a peer health worker and nurse-staffed community-based program in Uganda. JAIDS 2009;50:276-282. PMCID: PMC2662625
Chang LW, Kennedy CE, Kennedy GE, Lindegren ML, Marston BJ, Kaplan JE, Sweat MD, Bunnell RE, O’Reilly K, Rutherford GW, Mermin JH. Developing WHO guidelines with pragmatic, structured, evidence-based processes: a case study. Global Public Health 2010;5(4):395-412.
Chang LW, Harris J, Humphreys E. Optimal monitoring strategies for guiding when to switch first-line antiretroviral therapy regimens for treatment failure among adults and adolescents living with HIV in low-resource settings. Cochrane Database Syst Rev 2010;Apr 13(4):CD008494.
Chang LW, Kagaayi J, Nakigozi G, Ssempijja V, Packer A, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ. Effect of Peer Health Workers on AIDS Care in Rakai, Uganda: a Cluster-Randomized Trial. PLoS ONE 2010;5(6):e10923. PMCID: PMC2880005
Humphreys EH, Chang LW, Harris J. Antiretroviral regimens for patients with HIV who fail first-line antiretroviral therapy. Cochrane Database Syst Rev 2010; Jun 16(6):CD006517.
Chang LW, Kaye D, Muhwezi WW, Nabirye RC, Mbalinda S, Okullo I, Groves S, Kennedy CE, Bollinger RC, Sisson S, Burnham G, Mwanika A. Perceptions and Valuation of a Community-Based Education and Service (COBES) Program in Uganda. Medical Teacher 2011;33:e9-e15.
Kaye D, Mwanika A, Burnham G, Chang LW, Mbalinda S, Okullo I, Nabirye RC, Muhwezi W, Oria H, Kijjambu S, Atuyambe L, Aryeija W. The organization and implementation of community-based education programs for health worker training institutions in Uganda. BMC International Health and Human Rights 2011;11(Suppl 1):S4. PMCID: PMC3059476
Mwanika A, Okullo I, Kaye D, Muhwezi W, Atuyambe L, Nabirye RC, Groves S., Mbalinda S, Burnham G, Chang LW, Oria H, Sewankambo N. Perception and valuations of community-based education and service by alumni at Makerere University College of Health Sciences. BMC International Health and Human Rights 2011;11(Suppl 1):S5. PMCID: PMC3059477
Arem H, Nakyanjo N, Kagaayi J, Mulamba J, Nakigozi G, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ, Chang LW. Peer Health Workers and AIDS Care in Rakai, Uganda: a Mixed Methods Operations Research Evaluation of a Cluster-Randomized Trial. AIDS Patient Care and STDs 2011;25(12):719-724. PMCID: PMC3216066
Chang LW, Kagaayi J, Arem H, Nakigozi G, Ssempijja V, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ. Impact of a mHealth Intervention for Peer Health Workers on AIDS Care in Rural Uganda: a Mixed Methods Evaluation of a Cluster-Randomized Trial. AIDS and Behavior 2011;15:1776-1784. PMC Journal - In Process
Njie-Carr V, Kalenge S, Kelley J, Wilson A, Muliira JK, Nabirye RC, Glass N, Bollinger RC, Alamo-Talisun S, Chang LW. Research Capacity Building Program for Clinicians and Staff at a Community-Based HIV/AIDS Clinic in Uganda: A Pre/Post Evaluation. Journal of the Association of Nurses in AIDS Care 2012;23:431-441..
Chang LW, Mwanika A, Kaye D, Muhwezi W, Nabirye RC, Mbalinda S, Okullo I, Kennedy CE Groves S, Sisson SD, Burnham G, Bollinger RC. Information and communication technology and community-based health sciences training in Uganda: perceptions and experiences of educators and students. Informatics for Health and Social Care 2012;37(1):1-11. PMC Journal - In Process
Thompson MA, Mugavero MJ, Amico KR, Cargill VA, Chang LW, Gross R, Orrell C, Altice FL, Bangsberg DR, Bartlett JG, Beckwith CG, Dowshen N, Gordon CM, Horn T, Kumar P, Scott JD, Stirratt MJ, Remien RH, Simoni JM, Nachega JB. Guidelines for Improving Entry Into and Retention in Care and Antiretroviral Adherence for Persons With HIV: Evidence-Based Recommendations From an International Association of Physicians in AIDS Care Panel. Annals of Internal Medicine 2012;156:817-833.
Chang LW, Kadam DB, Sangle S, Narayanan S, Borse RT, McKenzie-White J, Bowen CW, Sisson SD, Bollinger RC. Evaluation of a Multimodal, Distance Learning HIV Management Course for Clinical Care Providers in India. J Int Assoc Physicians AIDS Care 2012;11(5):277-82.
Chang LW, Kagaayi J, Nakigozi G, Serwadda D, Quinn TC, Gray RH, Bollinger RC, Reynolds SJ, Holtgrave D. Cost analyses of peer health worker and mHealth support interventions for improving AIDS care in Rakai, Uganda [in press]. AIDS Care.
Chang LW, Serwadda D, Quinn TC, Wawer MJ, Gray RH, Reynolds SJ. Combination implementation for HIV prevention: moving from evidence to population-level impact [in press]. The Lancet Infectious Diseases.
H Tumwebaze, Tumwesigye E, Baeten JM, Kurth AE, Revall J, Murnane PM, Chang LW, Celum C.
Household-based HIV counseling and testing as a platform for targeted referral to HIV care and medical male circumcision in Uganda: a pilot evaluation [in press]. PLoS One.
Effect of Peer Health Workers on Retention, Care, and Secondary HIV Prevention of People Living with HIV: A Randomized Trial