I am an physician trained in internal medicine, infectious diseases, and epidemiology with an interest in multidisciplinary, innovative, and pragmatic approaches to impacting the HIV/AIDS pandemic. I have 3 main areas of focus in my scholarship and leadership activities.
1. HIV/AIDS Implementation and Operations Research- My main focus is on developing innovative and pragmatic strategies for improving HIV/AIDS care in low- and middle-income settings and performing implementation and operations research to assess impact and implementation challenges. These strategies include involving community health workers to help address the human resource crisis through improving clinical care, improving linkage, engagement, and retention in care, and through integrating HIV prevention and care interventions. I primarily work in Africa, mostly in Uganda with the Rakai Health Sciences Program, and try to bring to this growing and multidisciplinary field of HIV/AIDS Implementation/Operations Research application of quantitative methods, qualitative methods, community-based trial designs, as well as behavioral science and economic evaluations.
2. Global mHealth-A related and growing focus of my research is using novel mHealth (mobile technologies for health) strategies for improving global public health and clinical care, including novel applications for maternal/child health, intimate-partner violence, and HIV care, surveillance, and prevention. I am the Director of Science and Implementation for the Hopkins-based eMOCHA (electronic Mobile Open-source Comprehensive Health Application) mHealth Platform (www.emocha.org), and I oversee active projects involving eMOCHA in Baltimore, Afghanistan, and Uganda. I am a member of the newly formed Steering Committee for a University-wide Johns Hopkins Global mHealth Initiative.
3. HIV/AIDS Systematic Reviews and Guideline Development-I am also actively involved in systematic reviews on topics in HIV as well as on guideline development. I am an active member of the Cochrane HIV/AIDS group. I have been an active member in WHO guideline development for the past 6 years, most recently having a role in the 2010 update of HIV treatment guidelines. I am currently the Methodology Section Head for the development of new global guidelines on adherence and retention sponsored by the International Association of Providers of AIDS Care (IAPAC).
AIDS, HIV, antiretroviral therapy, operational research, mobile phones, information communications technology, ict, smartphones, community health workers, peer health workers, mhealth, ehealth, africa, uganda, implementation research, medical education, online, internet, human resources, world health organization, guidelines, WHO, task shifting, adherence, mixed methods
Aberg JA, Watson J, Segal M, Chang LW. Clinical utility of monitoring serum cryptococcal antigen (sCRAG) titers in patients with AIDS-related cryptococcal disease. HIV Clinical Trials 2000;1:1-6.
Chang LW, Osei-Kwasi M, Boakye D, Aidoo S, Hagy A, Curran JW, Vermund SH. HIV-1 and HIV-2 Seroprevalence and risk factors among hospital outpatients in the Eastern Region of Ghana, West Africa. JAIDS 2002;29:511-516.
Macharia DK, Chang LW, Lule G, Owili DM, Tesfaledet G, Patel S, Silverstein DM, Ng’ang’a L, Bush T, De Cock KM, Weidle PJ. Antiretroviral therapy in the private sector of Nairobi, Kenya: a review of the experience of five physicians. AIDS 2003;17(6):938-940.
Chang LW, Phipps WP, Kennedy GF, Rutherford GW. Antifungal interventions for the primary prevention of cryptococcal disease in adults with HIV. In: The Cochrane Library, Issue 3, 2005. Chichester, UK: John Wiley & Sons, Ltd.
Chang LW, Vidyarthi AR, Kohlwes RJ. Baseline duty hours recorded with time-cards: a pre-regulation study of internal medicine residents. Medical Education 2006;40(7):662-667.