Center for Global Health Faculty
Academic Degrees
Departmental Address
600 North Wolfe Street, CMSC 3-122
Baltimore, MD 21287
Research and Professional Experience
1. Protein processing of misfolded dF508 CFTR, alpha-1-antitrypsin Z mutant and other conformational mutant proteins. 2. Functional role of VCP/p97 (AAA ATP chaperone) in ERAD, protein aggregation and forward trafficking pathways, and identification of sites for selective interaction and/or post translational modification for therapeutic intervention. 3. Mechanisms of ubiquitination and deubiquitination of misfolded proteins, and identification of substarte specific ubuitinating ligases (E1/E2/E3s) and deubiquitinating enzymes (DUBs like Ub C-terminal hydrolases, UCHs or ubiquitin specific proteases, USPs). 4. Chronic airway inflammation with emphasis on the role of PGE-2, IL8 and neutrophil chemotaxis. 5. Immune privilege and wound healing
Keywords
Inflammation, Cystic Fibrosis, COPD, Emphysema, Lung Diseases, Corneal Diseases, ERAD, Proteasome, Extracellular Matrix, Functional Genomics and Proteomics
Honors and Awards
2001-2002 Scientific Research Fellowship (BAT IIa) from German Research Council 2000-2001 ITC fellowship, Joint fellowship from Hungarian Academy of Sciences, UNESCO & EMBO 1998 summa cum laude MS (Microbiology), first rank in University
Selected Publications
(1.) Vij, N., Roberts, L., Joyce, S. and Chakravarti, S. 2004. Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea. Exp. Eye Res. 78(5): 957-971. (2.) Chakravarti, S., Wu, F., Vij, N., Roberts, L., Hassell, J and S. Joyce. 2004. Microarray studies reveal macrophage-like function of stromal keratocytes in the cornea. Invest Ophthalmol Vis Sci. 45(10):3475-3484. (3.) Vij, N., Roberts, L., Joyce, S. and Chakravarti, S. 2005. Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling. Invest Ophthalmol Vis Sci. 46 (1): 88-95. (4.) Vij, N. and Zeitlin, PL. 2006. Regulation of the ClC-2 Lung Epithelial Chloride Channel by Glycosylation of SP1. Am J Respir Cell Mol Biol. Jun;34(6):754-9. (5.) Singh, OV., Vij, N., Mogayzel, P., Jozwik, C., Pollard, H and Zeitlin, PL. 2006. Pharmacoproteomics of 4-Phenylbutyrate-treated cystic fibrosis bronchial epithelial cells (IB3-1) J. Proteome Res. 5(3):562-71. (6.) Vij, N., Fang, S. and Zeitlin, PL. 2006. Selective inhibition of ERAD rescues ?F508-CFTR and suppresses IL8 levels: therapeutic implications. J Biol Chem. Jun 23;281(25):17369-78. (7.) Wu F, Vij N*, Roberts L, Lopez S, Joyce S, Chakravarti S. 2007. A novel role of the lumican core protein in bacterial LPS-induced innate immune response. J Biol Chem. Sep 7;282(36):26409- 17. (8.) Vij N, Amoako MO, Mazur S and Zeitlin PL. 2008. CHOP transcription factor mediates IL-8 signaling in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol. Feb;38(2):176-84. (9.) Vij N, Sharma, A, Thakkar, M, Sinha, S and Mohan RR. 2008. PDGF-driven proliferation, migration and IL-8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway. Mol. Vis. May 30;14:1020-7. (10.) Cebotaru L, Vij N, Ciobanu I, Wright J, Flotte T and Guggino WB. 2008. A mutant form lacking the first four transmembrane segments of CFTR engages key ERAD proteins and enhances wt and ?F508-CFTR protein expression. J Biol Chem. Aug 8; 283: 21926-33. (11.) Vij N. 2008. AAA ATPase p97/VCP: cellular function, disease and therapeutic potential (Point of View) J Cell Mol Med. Dec;12(6A):2511-8. (12.) MacDonald KD, McKenzie KR, Henderson MJ, Hawkins, CE, Vij N and Zeitlin PL. 2008.Lubiprostone Activates non-CFTR dependent Respiratory Epithelial Chloride Secretion in Cystic Fibrosis Mice. Am J Physiol Lung Cell Mol Physiol. Nov;295(5):L933-40. (13) Vij N, Mazur S and Zeitlin PL. CFTR is a negative regulator of NFkB mediated innate immune response. PLoS One, In Press.
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