>
 
 
>
 
 
>
 
  Search the Site

Center for Global Health Faculty

Richard E. Chaisson

Professor

Director, Center for TB Research, Principal Investigator, Center for AIDS Research

Richard E. Chaisson

Academic Degrees

  • MD

Departmental Affiliation

  • Name:
    Epidemiology
    Affiliation Type:
    Primary
    Division:
    Infectious Diseases

Departmental Address

1550 Orleans St., Room 1M.08 Baltimore, MD 21231

Contact Information

Phone:
410-955-1755
Fax:
410-955-0740
Link:
Personal Website
Link:
SciVal Experts Research Profile

Research and Professional Experience

Richard E. Chaisson, M.D., is Professor of Medicine, Epidemiology and International Health and Director of the Johns Hopkins University Center for Tuberculosis Research and Principal Investigator of the Hopkins Center for AIDS Research (CFAR). The Center for Tuberculosis Research is a multidisciplinary research and training center with more than $180 million in grants for the study of TB from bench to bedside.  The new CFAR is a $16 million program to promote interdisciplinary HIV research, support new investigators and address the Baltimore HIV epidemic.

Dr. Chaisson's research interests focus on tuberculosis and HIV infection, including global epidemiology and control, prevention, clinical trials, and public health interventions. He is currently principal investigator of 11 research grants, and is principal investigator of the Consortium to Respond Effectively to the AIDS/TB Epidemic (CREATE), an international research consortium funded by the Bill and Melinda Gates Foundation to assess the impact of novel strategies for controlling HIV-related TB. He has published over 380 scientific papers and book chapters.

Keywords

Tuberculosis, HIV, Infectious Diseases

Honors and Awards

World Lung Health Award, American Thoracic Society, 2006

Selected Publications

Golub JE, Saraceni V, Cavalcante SC, Pacheco AG, Moulton LH, King BS, Efron A, Moore RD, Chaisson RE, Durovni B.  The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil.  AIDS. 2007;21:1441-8.

 

Martinson NA, Karstaedt A, Venter WD, Omar T, King P, Mbengo T, Marais E, McIntyre J, Chaisson RE, Hale M.  Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study.  AIDS.  2007;21:2043-50.

 

Rosenthal IM, Zhang M, Williams KN, Peloquin CA, Tyagi S, Vernon AA, Bishai WR, Chaisson RE, Grosset JH, Nuermberger EL.  Daily Dosing of Rifapentine Cures Tuberculosis in Three Months or Less in the Murine Model.PLoS Med. 2007 Dec 18;4(12):e344.

 

Hoffmann CJ, Fielding KL, Charalambous S, Sulkowski MS, Innes C, Thio CL, Chaisson RE, Churchyard GJ, Grant AD.  Antiretroviral therapy using zidovudine, lamivudine, and efavirenz in South Africa: tolerability and clinical events. AIDS. 2008 Jan 2;22(1):67-74.

 

Pemba L, Charalambous S, von Gottberg A, Magadla B, Moloi V, Seabi O, Wasas A, Klugman KP, Chaisson RE, Fielding K, Churchyard GJ, Grant AD.   Impact of cotrimoxazole on non-susceptibility to antibiotics in Streptococcus

 

pneumoniae carriage isolates among HIV-infected mineworkers in South Africa. J Infect. 2008;56:171-8.

 

Pope DS, Deluca AN, Kali P, Hausler H, Sheard C, Hoosain E, Chaudhary MA, Celentano DD, Chaisson RE.  A Cluster-Randomized Trial of Provider-Initiated (Opt-Out) HIV Counseling and Testing of Tuberculosis Patients in South Africa. J Acquir Immune Defic Syndr. 2008;48:190-195. PMCID: 2632747

 

Saraceni V, King BS, Cavalcante SC, Golub JE, Lauria LM, Moulton LH, Chaisson RE, Durovni B. Tuberculosis as primary cause of death among AIDS cases in Rio de Janeiro, Brazil. Int J Tuberc Lung Dis. 2008;12:769-72.

 

Charalambous S, Grant AD, Moloi V, Warren R, Day JH, van Helden P, Hayes RJ, Fielding KL, De Cock KM, Chaisson RE, Churchyard GJ.  Contribution of reinfection to recurrent tuberculosis in South African gold miners.  Int J Tuberc Lung Dis. 2008;12:942-8.

 

Dowdy DW, Chaisson RE, Maartens G, Corbett EL, Dorman SE.  Impact of enhanced tuberculosis diagnosis in South Africa: a mathematical model of expanded culture and drug susceptibility testing. Proc Natl Acad Sci U S A. 2008;105(32):11293-8. PMCID: 2516234

 

Dooley K, Flexner C, Hackman J, Peloquin CA, Nuermberger E, Chaisson RE, Dorman SE.  Repeated administration of high-dose intermittent rifapentine reduces rifapentine and moxifloxacin plasma concentrations. Antimicrob Agents Chemother. 2008; 52(11):4037-42. PMCID: 2573112

 

Pacheco AG, Durovni B, Cavalcante SC, Lauria LM, Moore RD, Moulton LH, Chaisson RE, Golub JE.  AIDS-related tuberculosis in Rio de Janeiro, Brazil. PLoS ONE. 2008;3(9):e3132.  PMCID: 2518952

 

Nachega JB, Hislop M, Dowdy DW, Gallant JE, Chaisson RE, Regensberg L, Maartens G. Efavirenz versus nevirapine-based initial treatment of HIV infection: clinical and virological outcomes in Southern African adults.  AIDS 2008;208:2117-25.  PMCID: 2659649

 

Hoffmann CJ, Charalambous S, Martin DJ, Innes C, Churchyard GJ, Chaisson RE, Grant AD, Fielding KL, Thio CL. Hepatitis B virus infection and response to antiretroviral therapy (ART) in a South African ART program. Clin Infect Dis. 2008; 47(11):1479-85. PMCID: 2670447

 

Pacheco AG, Saraceni V, Tuboi SH, Moulton LH, Chaisson RE, Cavalcante SC, Durovni B, Faulhaber JC, Golub JE, King B, Schechter M, Harrison LH. Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil. Am J Epidemiol. 2008; 168(11):1326-32.  PMCID: 2638543

 

Golub JE, Astemborski J, Ahmed M, Cronin W, Mehta SH, Kirk GD, Vlahov D, Chaisson RE.  Long-Term Effectiveness of Diagnosing and Treating Latent Tuberculosis Infection in a Cohort of HIV-Infected and At-Risk Injection Drug Users.  J Acquir Immune Defic Syndr. 2008; 49(5):532-7.  PMCID: 2637943

 

Golub JE, Durovni B, King BS, Cavalacante SC, Pacheco AG, Moulton LH, Moore RD, Chaisson RE, Saraceni V.  Recurrent tuberculosis in HIV-infected patients in Rio de Janeiro, Brazil. AIDS. 2008;22:2527-2533.  PMCID: 2603140

 

Dowdy DW, Lourenco MC, Cavalcante SC, Saracen V, King B, Golub JE, Bishai D, Durovni B, Chaisson RE, Dorman SE.  Impact and cost-effectiveness of culture for diagnosis of tuberculosis in HIV-infected Brazilian adults. PLoS ONE 2008; 3(12): e4057.   PMCID: 2614861

 

Aguiar F, Vieira MA, Staviack A, Buarque C, Marsico A, Fonseca L, Chaisson RE, Kristski A, Werneck G, Mello F. Prevalence of anti-tuberculosis drug resistance in an HIV/AIDS reference hospital in Rio de Janeiro, Brazil.  Int J Tuberc Lung Dis. 2009; 13:54-61.

 

Conde MB, Efron A, Loredo C, De Souza GRM, Graça NP, Cezar MC, Ram M, Chaudhary MA, BishaiWR, Kritski AL, Chaisson RE.  Moxifloxacin versus ethambutol in the initial therapy of tuberculosis: A randomized, controlled, phase 2 Trial.  Lancet 2009,373:1183-9.

 

Nachega JB, Hislop M, Nguyen H, Dowdy DW, Chaisson RE, Regensberg L, Cotton M, Maartens G. Antiretroviral Therapy Adherence, Virologic and Immunologic Outcomes in Adolescents Compared With Adults in Southern Africa. J Acquir Immune Defic Syndr. 2009 2009;51:65-71.  PMCID: 2674125

 

Ribeiro S, Dooley K, Hackman J, Loredo C, Efron A, Chaisson RE, Conde MB, Boechat N, Dorman SE. T-SPOT.TB responses during treatment of pulmonary tuberculosis. BMC Infect Dis. 2009;9:23.  PMCID: 2651889

 

Cailleaux-Cezar M, de A Melo D, Xavier GM, de Salles CL, de Mello FC, Ruffino-Netto A, Golub JE, Efron A, Chaisson RE, Conde MB. Tuberculosis incidence among contacts of active pulmonary tuberculosis. Int J Tuberc Lung Dis. 2009; 13:190-5.

 

Golub JE, Pronyk P, Mohapi L, Thsabangu N, Moshabela M, Struthers H, Gray GE, McIntyre JA, Chaisson RE, Martinson NA.  Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohort.  AIDS 2009;23:631-6.

 

Dorman SE, Johnson JL, Goldberg S, Muzanye G, Padayatchi N, Bozeman L, Heilig CM, Bernardo J, Choudhri S, Grosset JH, Guy E, Guyadeen P, Leus MC, Maltas G, Menzies D, Nuermberger EL, Villarino M, Vernon A, Chaisson RE. Substitution of Moxifloxacin for Isoniazid During Intensive Phase Treatment of Pulmonary Tuberculosis. Am J Respir Crit Care Med. 2009;180:273-80.

 

Dowdy DW, Chaisson RE. The persistence of tuberculosis in the age of DOTS: reassessing the effect of case detection.  Bull WHO 2009; 87:296–304.   PMCID: PMC2672581.

 

Hoffmann CJ, Charalambous S, Fielding KL, Innes C, Chaisson RE, Grant AD, Churchyard GJ. HIV suppression with stavudine 30 mg versus 40mg in adults over 60 kg on antiretroviral therapy in South Africa. AIDS. 2009;23:1784-6.

 

Martinson NA, Moultrie H, van Niekerk R, Barry G, Coovadia A, Cotton M, Violari A, Gray GE, Chaisson RE, McIntyre JA, Meyers T. HAART and risk of tuberculosis in HIV-infected South African children: a multi-site retrospective cohort. Int J Tuberc Lung Dis. 2009;13:862-7.

 

Shah M, Variava E, Holmes CB, Coppin A, Golub JE, McCallum J, Wong M, Luke B, Martin DJ, Chaisson RE, Dorman SE, Martinson NA. Diagnostic Accuracy of a Urine Lipoarabinomannan Test for Tuberculosis in Hospitalized Patients in a High HIV Prevalence Setting. J Acquir Immune Defic Syndr. 2009;52:145-51.

 

Hoffmann CJ, Charalambous S, Sim J, Ledwaba J, Schwikkard G, Chaisson RE, Fielding KL, Churchyard GJ, Morris L, Grant AD. Viremia, Resuppression, and Time to Resistance in Human Immunodeficiency Virus (HIV) Subtype C during First-Line Antiretroviral Therapy in South Africa. Clin Infect Dis. 2009;49:1928-35.

 

Cavalcante SC, Durovni B, Barnes GL, Souza FB, Silva RF, Barroso PF, Mohan CI, Miller A, Golub JE, Chaisson RE. Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil.  Int J Tuberc Lung Dis 2010;14:203-9.

 

Guerra RL, Conde MB, Efron A, Loredo C, Bastos G, Chaisson RE, Golub JE. Point-of-care Arkansas method for measuring adherence to treatment with isoniazid. Respir Med. 2010 Mar 2. [Epub ahead of print]

 

Pope DS, Atkins S, DeLuca AN, Hausler H, Hoosain E, Celentano DD, Chaisson RE.  South African TB nurses' experiences of provider-initiated HIV counseling and testing in the Eastern Cape Province: a qualitative study. AIDS Care. 2010;22:238-45.

Nachega JB, Chaisson RE, Goliath R, Efron A, Chaudhary MA, Ram M, Morroni C, Schoeman H, Knowlton AR,      Maartens G. Randomized controlled trial of trained patient-nominated treatment supporters providing partial directly observed antiretroviral therapy. AIDS. 2010;24:1273-80.  PMCID: PMC2888722

Shah M, Martinson NA, Chaisson RE, Martin DJ, Variava E, Dorman SE.  Quantitative analysis of a urine-based assay for lipoarabinomannan in patients with tuberculosis. J Clin Microbiolo 2010;48:2972-4.  PMC2916614

Nahid P, Bliven EE, Kim EY, Mac Kenzie WR, Stout JE, Diem L, Johnson JL, Gagneux S, Hopewell PC, Kato-Maeda M; Tuberculosis Trials Consortium. [RE Chaisson, Protocol Chair and Site PI]  Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis.  PLoS One, 2010;5:e10753. PMCID: PMC2873999

Hanrahan CF, Golub JE, Mohapi L, Tshabangu N, Modisenyane T, Chaisson RE, Gray GE, McIntyre JA, Martinson NA.  Body mass index and risk of tuberculosis and death.  AIDS 2010;24:1501-8.

Miller AC, Golub JE, Cavalcante SC, Durovni B, Moulton LH, Fonseca Z, Arduini D, Chaisson RE, Soares EC.  Controlled trial of active tuberculosis case finding in a Brazilian favela.  Int J Tuberc Lung Dis. 2010;14:720-6.

Hoffmann CJ, Fielding KL, Charalambous S, Innes C, Chaisson RE, Grant AD, Churchyard GJ.  Reducing mortality with cotrimoxazole preventive therapy at initiation of antiretroviral therapy in South Africa. AIDS. 2010;24:1709-16.

Fielding KL, Grant AD, Hayes RJ, Chaisson RE, Corbett EL, Churchyard GJ.  Thibela TB: Design and methods of a cluster randomised trial of the effect of community-wide isoniazid preventive therapy on tuberculosis amongst gold miners in South Africa. Contemp Clin Trials. 2011;32:382-92.

Durovni B, Cavalcante SC, Saraceni V, Vellozo V, Israel G, King BS, Cohn S, Efron A, Pacheco AG, Moulton LH, Chaisson RE, Golub JE. The implementation of isoniazid preventive therapy in HIV clinics: the experience from the TB/HIV in Rio (THRio) study. AIDS. 2010 Nov;24 Suppl 5:S49-56.

Pacheco AG, Saraceni V, Tuboi SH, Lauria LM, Moulton LH, Faulhaber JC, King B, Golub JE, Durovni B, Cavalcante S, Harrison LH, Chaisson RE, Schechter M. Estimating the extent of underreporting of mortality among HIV-infected individuals in Rio de Janeiro, Brazil. AIDS Res Hum Retroviruses. 2011;27:25-8. PMCID:PMC3026651.

Churchyard GJ, Fielding K, Roux S, Corbett EL, Chaisson RE, De Cock KM, Hayes RJ, Grant AD. Twelve-monthly versus six-monthly radiological screening for active case-finding of tuberculosis: a randomised controlled trial. Thorax. 2011;66:134-9.

Gounder CR, Wada NI, Kensler C, Violari A, McIntyre J, Chaisson RE, Martinson NA. Active Tuberculosis Case-Finding among Pregnant Women Presenting to Antenatal Clinics in Soweto, South Africa. J Acquir Immune Defic Syndr. 2011: 57(4):e77-84.

Kasambira TS, Shah M, Adrian PV, Holshouser M, Madhi SA, Chaisson RE, Martinson NA, Dorman SE.  QuantiFERON®-TB Gold In-Tube for the detection of Mycobacterium tuberculosis infection in children with household tuberculosis contact.  Int J Tuberc Lung Dis 2011;15:628-34.

Saraceni V, Pacheco AG, Golub JE, Vellozo V, King BS, Cavalcante SC, Eldred L, Chaisson RE, Durovni B. Physician adherence to guidelines for tuberculosis and HIV care in Rio de Janeiro, Brazil. Braz J Infect Dis. 2011;15:249-52.

Lawn SD, Harries AD, Williams BG, Chaisson RE, Losina E, De Cock KM, Wood R.  Antiretroviral therapy and the control of HIV-associated tuberculosis. Will ART do it?  Int J Tuberc Lung Dis 2011;15:571-581.

Wilson D, Mbhele L, Badri M, Morroni C, Nachega J, Chaisson RE, Maartens G.

Evaluation of the World Health Organization algorithm for the diagnosis of HIV-associated sputum smear-negative tuberculosis. Int J Tuberc Lung Dis. 2011;15:919-24.

 

Martinson NA, Barnes GL, Moulton LH, Msandiwa R, Hausler H, Ram M, McIntyre JA, Gray GE, Chaisson RE.  New regimens to prevent tuberculosis in adults with HIV infection.  N Engl J Med 2011;365:11-20.

Gounder CR, Kufa T, Wada NI, Mngomezulu V, Charalambous S, Hanifa Y, Fielding K, Grant A, Dorman S, Chaisson RE, Churchyard GJ. Diagnostic Accuracy of a Urine Lipoarabinomannan Enzyme-Linked Immunosorbent Assay for Screening Ambulatory HIV-Infected Persons for TB. J Acquir Immune Defic Syndr. 2011;58:219-23.

Farley JE, Ram M, Pan W, Waldman S, Cassell GH, Chaisson RE, Weyer K, Lancaster J, Van der Walt M.  Outcomes of Multi-Drug Resistant Tuberculosis (MDR-TB) among a Cohort of South African Patients with High HIV Prevalence.  PLoS One. 2011;6(7):e20436.  PMCID: PMC3142109

Hoffmann CJ, Katherine FL, Victoria J, Salome C, Craig I, Moore RD, Chaisson RE, Grant AD, Churchyard GJ. Changing predictors of mortality over time from cART start: implications for care. J Acquir Immune Defic Syndr. 2011;58:269-76.

Sterling TR, Villarino ME, Borisov AS, Shang N, Gordin F, Bliven-Sizemore E, Hackman J, Hamilton CD, Menzies D, Kerrigan A, Weis SE, Weiner M, Wing D, Conde MB, Bozeman L, Horsburgh CR Jr, Chaisson RE; TB Trials Consortium PREVENT TB Study Team. Three months of rifapentine and isoniazid for latent tuberculosis infection.  N Engl J Med. 2011;365:2155-66.

Hsia EC, Schluger N, Cush J, Chaisson RE, Matteson EL, Xu S, Beutler A, Doyle MK, Hsu B, Rahman MU. Interferon-gamma release assay versus tuberculin skin test across RA, PsA, and AS patients prior to treatment with golimumab, a human anti-TNF antibody. Arthritis Rheum 2012; epub ahead of print.

Bliven-Sizemore EE, Johnson JL, Goldberg S, Burman WJ, Villarino ME, Chaisson RE, TB Trials Consortium.  Effect of HIV infection on tolerability and bacteriologic outcomes of tuberculosis treatment.  Int J Tuberc Lung Dis 2012; epub ahead of print.

Projects

      
About the Center l News Center l Event Calendar l Resources l Facebook l Contact Us
Student Travel Grants l Faculty Grants l Scholars l Events & Seminars l Collaborative Projects l Project Database

© 2011-2013 Johns Hopkins Center for Global Health