Director Meyerhoff Inflammatory Bowel Disease Genetics Laboratory
5103 E Jefferson Street, B136
Baltimore, MD 21231
Research and Professional Experience
My research interest is the genetic causes of inflammatory bowel disease (IBD), Crohn’s disease and ulcerative colitis and their genetic and environmental epidemiology. I am also examining clinical outcomes and racial disparity in IBD. My laboratory has been involved with the discovery of multiple genes and loci for Crohn’s disease. I am principle investigator of the Johns Hopkins Genetic Research Center (GRC) of the NIDDK IBD Genetics Consortium. The specific focus of our GRC is the genetics of IBD in African Americans. We are actively recruiting African American IBD patients and healthy controls for these studies. We are finding that some of the genes, like NOD2, that are strong risk factors in European ancestry Crohn’s disease are not risk factors in African Americans, whereas some, like IBD5, are risk factors in both populations . We are also searching for African ancestral risk variants, and we have a long term goal to perform a whole genome association study and admixture linkage disequilibrium mapping in African Americans to identify novel African ancestral IBD genes. We are also searching for disease genes for familial IBD by linkage mapping, and for IBD in Ashkenazi Jews, a population with the highest IBD incidence, by linkage disequilibrium mapping. We are modeling the effects of IBD genes and examining gene/gene and gene/environmental interactions in a population-based IBD case-control cohort in collaboration with the University of Manitoba Population-based IBD Research Registry. Lastly, in collaboration with the Hopkins Center for Health Disparity Solutions, we are evaluating African American and white IBD patients for differences in disease phenotype, complications, severity, quality of life, and health care utilization.
inflammatory bowel disease; Crohn's disease; ulcerative colitis; genetics; epidemiology
Honors and Awards
1991; American Gastroenterology Association Senior Fellow Research Award
1992; Clinician Scientist Award for Career Development, "Harvey/Burroughs-Wellcome
Clinician Scientist," The Johns Hopkins University School of Medicine
1993; FASEB Young Investigator Travel Award
1997; First Award, Crohn’s and Colitis Foundation of America
2004; Elected Member, American Society for Clinical Investigation (ASCI)
Shugart YY, Silverberg MS, Duerr RH, Taylor KD, Wang MH, Zarfas K, Schumm LP, Bromfield G, Steinhart AH, Griffiths AM, Kane SV, Barmada MM, Rotter JI, Mei L, Bernstein CN, Bayless TM, Langelier D, Cohen A, Bitton A, Rioux JD, Cho JH, and Brant SR. An SNP linkage scan identifies significant Crohn’s disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29. 2008 Genes and Immunity. In Press
Nguyen GC, Tuskey A, Dassopoulos T, Harris ML, Brant SR. Rising hospitalization rates for inflammatory bowel disease in the United States between 1998 and 2004. 2007. Inflamm Bowel Dis. 13:1529-35.
Nguyen GC, Tuskey A, Bayless TM, Laveist TA, Brant SR. Community-based Health Preferences for Proctocolectomy: A Race Comparison. 2007. Dig Dis Sci. In Press
Park JY, Farrance IK, Fenty NM, Hagberg JM, Roth SM, Mosser DM, Wang MQ, Jo H, Okazaki T, Bran...