Center for Global Health Faculty

Director Meyerhoff Inflammatory Bowel Disease Genetics Laboratory

Academic Degrees

Departmental Address

Contact Information

Email:

sbrant+jhmi.edu

Phone:

410-955-9679

Fax:

410-502-9913

Link:

SciVal Experts Research Profile

Research and Professional Experience

My research interest is the genetic causes of inflammatory bowel disease (IBD), Crohn’s disease and ulcerative colitis and their genetic and environmental epidemiology. I am also examining clinical outcomes and racial disparity in IBD. My laboratory has been involved with the discovery of multiple genes and loci for Crohn’s disease. I am principle investigator of the Johns Hopkins Genetic Research Center (GRC) of the NIDDK IBD Genetics Consortium. The specific focus of our GRC is the genetics of IBD in African Americans. We are actively recruiting African American IBD patients and healthy controls for these studies. We are finding that some of the genes, like NOD2, that are strong risk factors in European ancestry Crohn’s disease are not risk factors in African Americans, whereas some, like IBD5, are risk factors in both populations . We are also searching for African ancestral risk variants, and we have a long term goal to perform a whole genome association study and admixture linkage disequilibrium mapping in African Americans to identify novel African ancestral IBD genes. We are also searching for disease genes for familial IBD by linkage mapping, and for IBD in Ashkenazi Jews, a population with the highest IBD incidence, by linkage disequilibrium mapping. We are modeling the effects of IBD genes and examining gene/gene and gene/environmental interactions in a population-based IBD case-control cohort in collaboration with the University of Manitoba Population-based IBD Research Registry. Lastly, in collaboration with the Hopkins Center for Health Disparity Solutions, we are evaluating African American and white IBD patients for differences in disease phenotype, complications, severity, quality of life, and health care utilization.

Keywords

inflammatory bowel disease; Crohn's disease; ulcerative colitis; genetics; epidemiology

Honors and Awards

1991; American Gastroenterology Association Senior Fellow Research Award 1992; Clinician Scientist Award for Career Development, "Harvey/Burroughs-Wellcome Clinician Scientist," The Johns Hopkins University School of Medicine 1993; FASEB Young Investigator Travel Award 1997; First Award, Crohn’s and Colitis Foundation of America 2004; Elected Member, American Society for Clinical Investigation (ASCI)

Selected Publications

Shugart YY, Silverberg MS, Duerr RH, Taylor KD, Wang MH, Zarfas K, Schumm LP, Bromfield G, Steinhart AH, Griffiths AM, Kane SV, Barmada MM, Rotter JI, Mei L, Bernstein CN, Bayless TM, Langelier D, Cohen A, Bitton A, Rioux JD, Cho JH, and Brant SR. An SNP linkage scan identifies significant Crohn’s disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29. 2008 Genes and Immunity. In Press

Nguyen GC, Tuskey A, Dassopoulos T, Harris ML, Brant SR. Rising hospitalization rates for inflammatory bowel disease in the United States between 1998 and 2004. 2007. Inflamm Bowel Dis. 13:1529-35.

Nguyen GC, Tuskey A, Bayless TM, Laveist TA, Brant SR. Community-based Health Preferences for Proctocolectomy: A Race Comparison. 2007. Dig Dis Sci. In Press

Park JY, Farrance IK, Fenty NM, Hagberg JM, Roth SM, Mosser DM, Wang MQ, Jo H, Okazaki T, Brant SR, Brown MD. NFKB1 promoter variation implicates shear-induced eNOS gene expression and endothelial function in pre and stage I hypertensives. 2007 Am J Physiol Heart Circ Physiol. 293:H2320-7

Nguyen GC, Bayless TM, Powe NR, LaVeist TA, and Brant SR. Race and health insurance are predictors for undergoing bowel resection in hospitalized Crohn’s disease patients. Inflamm Bowel Dis. 13:1408-16.

Tao GZ, Strnad P, Zhou Q, Kamal A, Zhang L, Madani ND, Kugathasan S, Brant SR, Cho JH, Omary MB, Duerr RH. Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. 2007. Clin Gasteroenterol Hepatol 5:857-64

Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield G, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Louis E, Hafler DA, and Rioux JD. A biological pathway approach to disease association studies: Toll receptor pathway alleles and susceptibility to inflammatory bowel disease. 2007. Genes and Immunity. 8:387-97

Hugot JP, Zaccaria I, Cavanaugh J, Yang H, Vermeire S, Lappalainen M, Schreiber S, Annese V, Jewell DP, Fowler EV, Brant SR, Silverberg MS, Cho J, Rioux JD, Satsangi J, Parkes M; for the IBD International Genetics Consortium. Prevalence of CARD15/NOD2 Mutations in Caucasian Healthy People. 2007 Am J Gastroenterol. 102:1259-67.

Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, Mei L, Nicolae DL, Regueiro M, Schumm LP, Steinhart AH, Rotter JI, Duerr RH, Cho JH, Daly MJ, Brant SR. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. 2007. Nat Genet. 39:596-604.

Dassopoulos T, Nguyen GC, Bitton A, Bromfield GP, Schumm LP, Wu Y, Elkadri A, Regueiro M, Siemanowski B, Torres EA, Gregory FJ, Kane SV, Harrell LE, Franchimont D, Achkar JP, Griffiths A, Brant SR, Rioux JD, Taylor KD, Duerr RH, Silverberg MS, Cho JH, Steinhart AH. Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC). 2007 Inflamm Bowel Dis. 13:975-83.

Wu F, Dassopoulos T, Cope L, Maitra A, Brant SR, Harris ML, Bayless TM, Parmigiani G, Chakravarti S. Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: Insights into distinctive pathogenesis. 2007 Inflamm Bowel Dis. 13:807-21

Bernstein CN, Wang MH, Sargent M, Brant SR, Collins MT. Testing the interaction between NOD-2 status and serological response to Mycobacterium paratuberculosis in cases of inflammatory bowel disease. 2007 J Clin Microbiol. 45:968-71.

Brant SR, Wang MH, Rawsthorne P, Sargent M, Datta LW, Nouvet FJ, Shugart YY, and Bernstein CN. A population-based case control study of CARD15 and other risk factors in Crohn’s disease and ulcerative colitis. 2007. Am J Gastro. 102:313-23

Dassopoulos T, Frangakis C, Cruz-Correa M, Talor MV, Burek CL, Nouvet F, Bayless TM, and Brant SR. Higher titers of antibodies to Saccharomyces cerevisiae are associated with a higher probability of penetrating and stricturing Crohn’s disease independently of NOD2/CARD15 status. 2007. Inflamm Bowel Dis. 13:143-51.

Silverberg MS, Duerr RH, Brant SR, Bromfield G, Datta LW, Jani N, Kane SV, Rotter JI, Schumm LP, Steinhart AH, Taylor KD, Wu Y, Yang H, Cho JH, Rioux JD, Daly MJ of the NIDDK IBD Genetics Consortium. Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn’s disease. 2007. Eur J Hum Genet. 15: 328-35.

Nguyen GC, LaVeist TA,Gearhart S, Bayless TM, and Brant SR. Racial and Geographic Variations in Colectomy Rates Among Hospitalized Ulcerative Colitis Patients. 2006. Clin Gasteroenterol Hepatol. 4: 1507-1513.

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee A, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH. A Genome-wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene. 2006. Science; 314:1461-1463.

Panhuysen CI, Karban A, Manning AK, Bayless TM, Duerr RH, Bailey-Wilson JE, Epstein EH, and Brant SR. Identification Of Genetic Loci For Basal Cell Nevus Syndrome And Inflammatory Bowel Disease In A Single Large Pedigree. 2006. Hum Genet. 120:31-41.

Gewirtz AT, Vijay-Kumar M, Brant SR, Duerr RH, Nicolae DL, and Cho JH. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. Am J Physiol Gastrointest Liver Physiol. 2006. 290:G1157-63.

Achkar JP, Dassopoulous T, Silverberg MS, Tuvlin JA, Duerr RH, Brant SR, Siminovitch K, Reddy D, Datta LW, Bayless TM, Zhang L, Barmada MM, Rioux JD, Steinhart AH,, McLeod RS, Griffiths AM, Cohen Z, Yang H,, Bromfield GP, Schumm P, Hanauer SB, Cho JH, Nicolae DL and the NIDDK IBD Genetics Consortium. Disease location refines genomic localization in inflammatory bowel disease: IBD2 is an extensive ulcerative colitis locus. Inflammatory Bowel Disease 2006. 101:572-80.