Center for Global Health Faculty

Jonathan E. Golub

Assistant Professor

Associate Professor

Academic Degrees

Departmental Affiliation

Name:

Epidemiology

Affiliation Type:

Primary

Division:

Infectious Diseases

Departmental Address

1550 Orleans St., Suite 1M.07 Baltimore, MD 21231

Contact Information

Email:: jegolub+jhsph.edu
Phone:: 443-287-2969
Fax:: 410-955-0740

Research and Professional Experience

My primary research focus is the epidemiology of tuberculosis, primarily in the context of HIV infection. I currently lead a large community randomized trial in Brazil investigating isoniazid preventive therapy for HIV-infected patients as part of the Bill and Melinda Gates Foundation funded CREATE consortium. I also conduct research in South Africa, working on several HIV-related studies at the Chris Hani Baragwanath Hospital in Soweto. A strong interest is the association between smoking and TB and smoking and HIV. I am conducting studies in South Korea, Brazil, South Africa, Pakistan and the Republic of Georgia on smoking and TB, and recently began a smoking cessation trial in South Africa for HIV-infected patients. Another area of interest is diabetes and TB and we will soon be starting an NIH sponsored prospective cohort study investigating differences in TB outcomes between TB patients with and without TB.

Since 2005, I have been the primary instructor for the Epidemiologic Basis for Tuberculosis Control, a class developed by Dr. George W. Comstock. This course is conducted twice-yearly, both in class and online as part of the distance education program at Johns Hopkins University. I have also developed a one-year training course for Brazilian and South African clinicians and epidemiologists emphasizing methods in developing, implementing and analyzing epidemiologic studies. This course concentrates on HIV/TB population research, and has now expanded through another training grant to include trainees from these countries interested in HIV-related malignancies.

Keywords

epidemiology, tuberculosis, HIV

Selected Publications

Golub JE, Astemborski J, Ahmed M, Cronin W, Mehta SH, Kirk GD, Vlahov D, Chaisson RE. Long-term effectiveness of diagnosing and treating latent tuberculosis infection in a cohort of HIV-infected and at risk injection drug users. JAIDS 2008; In Press.

Cailleaux-Cezar M, Melo DA, Xavier GM, Salles CLG, Mello FCQ, Ruffino-Netto A, Golub JE, Efron A, Chaisson RE, Conde MB. Incidence of Tuberculosis Among Contacts of Active Pulmonary Tuberculosis. International Journal of Tuberculosis and Lung Disease 2008; In Press.

Pacheco AG, Durovni B, Cavalcante SC, Lauria LM, Moore RD, Moulton LH, Chaisson RE, Golub JE. AIDS-related tuberculosis in Rio de Janeiro, Brazil. PLoS ONE 2008; 3(9):e3132.

Pacheco AG, Saraceni V, Tubor SH, Moulton SH, Chaisson RE, Cavalcante SC, Durovni B, Faulhaber JC, Golub JE, King B, Schechter M, Harrison LH. Validation of a hierarchical deterministic record linkage algorithm using data from two different cohorts of HIV-infected individuals and mortality databases in Brazil. American Journal of Epidemiology 2008;168(11):1326-32

Golub JE, Durovni B, King BS, Cavalcante SC, Pacheco AG, Moulton LH, Moore RD, Chaisson RE, Saraceni V. Recurrent tuberculosis in HIV-infected patients in Rio de Janeiro, Brazil. AIDS 2008;22(18): 2527-2533.

Saraceni V, King BS, Cavalcante SC, Golub JE, Lauria LM, Moulton LH, Chaisson RE, Durovni B. Tuberculosis as primary cause of death among AIDS cases in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease 2008; 12(7): 769-72.

Luquero FJ, Sanchez-Padilla E, Simon-Soria F, Eiros JM, Golub JE. Trend and seasonality of tuberculosis in Spain, 1996-2004. International Journal of Tuberculosis and Lung Disease 2007; In Press.

Rabizadeh S, Rhee K, Wu S, Huso D, Gan CM, Golub JE, Wu X, Zhang M, Sears CL. Enterotoxigenic Bacteroides fragilis: A potential instigator of colitis. Inflamm Bowel Dis 2007; In Press

Panjabi R, Comstock GW, Golub JE. Recurrent tuberculosis and its risk factors: adequately treated patients are still at high risk. International Journal of Tuberculosis and Lung Disease 2007; 11(8):828-837.

Golub JE, Saraceni V, Cavalcante SC, Pacheco AG, Moulton LH, King BS, Efron A, Moore RD, Chaisson RE, Durovni B. The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil. AIDS 2007;21(11):1441-1448.

Moulton L, Golub JE, Durvoni B, Cavalcante S, Pacheco A, Saraceni V, King B, Chaisson RE. Statistical design of THRio: A phased implementation of a clinic-randomized study of a tuberculosis preventive therapy intervention. Clinical Trials 2007; 4(2):190-9.

Bastos LGV, Fonseca LS, Mello FQ, Ruffino-Netto A, Golub JE, Conde MB. Pulmonary tuberculosis prevalence among respiratory symptomatic subjects in an outpatient primary health service in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease 2007; 11(2):156-160.

Golub JE, Cronin WA, Bur S, Gange S, Baruch N, Comstock GW, Chaisson RE. Delayed tuberculosis diagnosis and tuberculosis transmission. International Journal of Tuberculosis and Lung Disease 2006; 10(1): 24-30.

Golub JE, Mohan CI, Comstock GW, Chaisson RE. Active case finding for tuberculosis: Historical perspective and future prospects. International Journal of Tuberculosis and Lung Disease 2005; 9(11): 1183-1203.

Golub JE, Bur S, Cronin WA, Gange S, Baruch N, Comstock GW, Chaisson RE. Patient and health care system delays in pulmonary tuberculosis diagnosis in a low-incidence state. International Journal of Tuberculosis and Lung Disease 2005; 9(9): 992-998.

Golub JE, Bur S, Sterling TR, Cronin WA, Gange S, Oden B, Baruch N, Comstock GW, Chaisson RE. Impact of empiric antibiotics and the chest radiograph on delays in the diagnosis of tuberculosis. International Journal of Tuberculosis and Lung Disease 2005; 9(4): 392-397.

Golub JE, Comstock GC. Chemoprophylaxis. In Tuberculosis, 5th Ed., (David Schlossberg, editor), McGraw-Hill, New York, 2005.

Bur S, Golub JE, Armstrong J, Myers K, Johnson B, Mazo D, Fielder JF, et al. An extensive tuberculosis contact investigation in an urban community and jail: lessons learned. International Journal of Tuberculosis and Lung Disease 2003; 7(12):S417-S423.

Chaisson RE, Armstrong J, Stafford J, Golub JE, Bur S. Safety and tolerability of intermittent rifampin/pyrazinamide for the treatment of latent tuberculosis infection in prisoners. JAMA 2002;288(2):165-6.

Cronin WA, Golub JE, Lathan MJ, Mukasa LN, Hooper N, Razeq J, Baruch NG, Mulcahy D, Benjamin WH, Magder LS, Strickland GT, Bishai WR. Molecular epidemiology of tuberculosis in a low- to moderate incidence state: are contact investigations enough? Emerging Infectious Diseases 2002;8(11):1271-1279.

Lathan M, Mukasa LN, Hooper N, Golub JE, Baruch N, Mulcahy M, Benjamin W, Cronin WA. Cross-jurisdictional transmission of Mycobacterium tuberculosis in Maryland and Washington, D.C. 1996-2000, linked to the homeless. Emerging Infectious Diseases 2002;8(11):1249-1251.

Dooley KE, Golub JE, Goes FS, Merz WG, Sterling TR. Empiric treatment of community-acquired pneumonia with fluoroquinolones and delays in the treatment of tuberculosis. Clinical Infectious Diseases 2002;34(12):1607-12.

Dooley KE, Golub JE, Sterling TR. The authors reply: Does the use of fluoroquinolones for the empiric treatment of pneumonia delay initiation of treatment of tuberculosis? Clinical Infectious Diseases 2002;35: 1572-73

Golub JE, Cronin WA, Obasanjo OO, Coggin W, Moore K, Pope DS, Thompson D, Sterling TR, Bishai WR, Chaisson RE. Transmission of Mycobacterium tuberculosis through casual contact with an infectious case. Archives of Internal Medicine 2001;161:2254-2258.

Cronin WA, Golub JE, Magder LS, Baruch NG, Lathan MJ, Mukasa LN, Hooper N, Razeq JH, Mulcahy D, Benjamin WH, Bishai WR. Epidemiologic Usefulness of Spoligotyping for Secondary Typing of Mycobacterium tuberculosis Isolates with Low Copy Numbers of IS6110. Journal of Clinical Microbiology 2001;39(10):3709-3711.