Center for Global Health Faculty

Academic Degrees

Departmental Address

Contact Information

Email:

sacktor+jhmi.edu

Phone:

410-550-0978

Fax:

410-550-0539

Link:

SciVal Experts Research Profile

Research and Professional Experience

Neurological complications continue to be an important cause of morbidity among HIV+ individuals. Dr. Sacktor's research focuses primarily on the cognitive manifestations of HIV infection. These investigations include clinical, epidemiological, and neuroimaging studies as well as trials of therapeutic agents for the treatment of HIV dementia.

With respect to international studies, Dr. Sacktor has developed and validated a screening tool for identifying HIV+ individuals at risk for HIV dementia, the International HIV Dementia Scale. Dr. Sacktor has focused his international studies of HIV dementia in Uganda. In collaboration with with the Academic Alliance Foundation, he has conducted studies evaluating the prevalence of HIV dementia in Kampala, Uganda, risk factors for cognitive impairment, and the effect of antiretroviral therapy on cognitve performance in HIV+ individuals with cognitive impairment. Dr. Sacktor is currently PI of a study evaluating the efficacy of minocycline for the treatment of HIV associated cognitive impairment in Uganda. Dr. Sacktor is also the PI of an R21 evaluating the epidemiology of HIV associated neurocognitive disorders (HAND) and sensory neuropathy in Uganda funded by NIMH.

Keywords

HIV, dementia, neurology

Honors and Awards

Adult AIDS Clinical Trials Group HIV Dementia Focus Group Chairman, 2004-2005

Adult AIDS Clinical Trials Group Neurology Subcommittee Chairman, 2006-2007

Selected Publications

Sacktor, N, Nakasujja, N., Skolasky, R., Robertson, K., Musisi, S., Ronald, A., Katabira, E., Clifford, D. B. Benefits and risks of stavudine therapy for HIV associated neurological complications in Uganda. Neurology 2009;72:165-170.

Robertson, K.R., Kopinsky, K.L., Hakim, J.G., Merry, C., Nakasujja, N., Hall, C.D., Traore, M., Sacktor, N., Clifford, D., Newton, C.R.J.C., Van Rie, A., Holding, P., et al. Second Assessment of NeuroAIDS in Africa. J Neurovirology 2008;14:87-101.

Wong, M. H., Robertson, K., Nakasujja, N., Skolasky, R., Musisi, S., Katabira, E., McArthur, J., Ronald, A., Sacktor, N. The frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 2007;68:350-355.

Cole, M., Margolick, J.B., Cox, C., Li, X., Selnes, O.A., Martin, E., Becker, J.T., Aranow, H.A., Cohen, B., Sacktor, N., Miller, E.N. Longitudinal preserved psychomotor performance in long term asymptomatic HIV infected individuals. Neurology 2007;69:2213-2220.

Antinori, A., Arendt, G., Becker, J.T., Brew, B.J., Byrd, D.A., Cherner, M., Clifford, D.B., Cinque, P., Epstein, L.G., Goodkin, K., Gisslen, M., Grant, I., Heaton, R.K., Joseph, J., Marder, K., Marra, C.M., McArthur, J.C., Nunn, M., Price, R.W., Pulliam, L., Robertson, K.R., Sacktor, N., Valcour, V., Wojna, V.E. Updated nosology for HIV-associated neurocognitive disorders (HAND), Neurology 2007;69:1789-1799.

Schifitto, G, Zhang, J., Evans, S.R., Sacktor, N, Simpson, D., Millar, L., Hung, V.L., Miller, E., Smith, E., Ellis, R.J., Valcour, V., Singer, E., Marr, C., Kolson, D., Weihe, J., Remmel, R., Katzenstein, D., Clifford, D., and the ACTG A5090 Team. A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment. Neurology 2007;69(13)1314-1321.

Wachtman, L.M., Skolasky, R.L., Esposito, D., Schifitto, G., Marder, K., McDermott, M., Cohen, B., Nath, A., Sacktor, N., Mankowski, J.L., McArthur, J.C. Platelet decline: a predictive marker for incident human immunodeficiency virus (HIV)- associated dementia. Arch Neurol 2007;64(9):1264-1272.

Sacktor, N., Skolasky, R., Selnes, O., Watters, M., Poff, P., Shiramizu, B., Shikuma, C., Valcour, V. Neuropsychological test profile differences between young and old HIV+ individuals. J Neurovirology 2007;13:203-209.

Sacktor, N, Nakasujja, N., Robertson, K., Clifford, D. HIV-associated cognitive impairment in Sub-Saharan Africa: the potential impact of clade diversity. Nature Clinical Practice Neurology 2007 Aug;3(8) 436-443.

Robertson, K., Nakasujja, N., Wong, M., Musisi, S., Katabira, E., Parsons, T., Ronald, A., Sacktor, N. Pattern of neuropsychological performance among HIV positive patients in Uganda. BioMed Central Neurology 2007 Apr 5;7:8.

Bandaru, V.V.R., McArthur, J.C., Sacktor, N., Cutler, R., Kanpp, E., Mattson, M.P., Haughey, N.J. Associative and predictive biomarkers of changing cognitive status in HIV-1 infected patients. Neurology 2007;68(18):1481-1487.

Sacktor, N., Nakasujja, N., Skolasky, R., Robertson, K., Wong, M., Musisi, S., Ronald, A., Katabira, E. Antiretroviral therapy improves cognitive impairment in HIV+ individuals in sub-Saharan Africa. Neurology 2006; 68: 350-355.

Riedel, D., Ghate, M., Nene, M., Mehendale, S., Bollinger, R., Sacktor, N., McArthur, J., Nath, A. Screening for HIV dementia in an HIV, clade C-infected population in India. J Neurovirology 2006;12-34-38.

Hammoud, D.A., Endres, C.J., Chandler, A.R., Guilarte, T.R., Wong, D.F., Sacktor, N., McArthur, J. C., Pomper, M.C. Imaging glial cell activation with [ 11C]-R-PK11195 in patients with AIDS. J Neurovirology 2005;11:346-355.

Sacktor, N., Wong, M., Nakasujja, N., Skolasky, R., Selnes, O., Musisi, S., Robertson, K., McArthur, J., Ronald, A., Katabira, E. The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 2005;19:1367-1374.

Cysique, L.A., Brew, B.J., Halman, M., Catalan, J., Sacktor, N., Price, R.W., Brown, S., Atkinson, H.J., Clifford, D. B., Simpson, D., Torres, G., Hall, C., Power, C., Marder, K., Mcarthur, J.C., Symonds, W., Romero, C. Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in HAART-treated patients. J Acquir Immune Defic Syndr 2005;39:426-429.

Schifitto, G., McDermott, M.P., McArthur, J.C., Marder, K., Sacktor, N., McClernon, D.R., Conant, K., Cohen, B., Epstein, L.G., Kieburtz, K., and the NEAD Consortium. Markers of immune activation and viral load in HIV-associated sensory neuropathy. Neurology 2005;64:842-848.

Sacktor, N., Skolasky, R.L., Ernst, T., Mao, X., Selnes, O., Pomper, M.G., Chang, L., Zhong, K., Shungu, D., Marder, K., Shibata, D., Schifitto, G., Bobo, L., Barker, P.B. A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia. J Magnet Reson Imaging 2005;21:325-333.

Valcour, V.G., Shikuma, C.M., Shiramizu, B.T., Williams, A.E., Watters, M.R., Poff, P.W., Grove, J.S., Selnes, O.A., Sacktor, N.C. Diabetes, insulin resistance, and dementia among HIV-1-infected patients. J Acquir Immune Defic Syndr 2005;38:31-36.

Sacktor, N., Haughey, N., Cutler, R., Tamara, A., Turchan, J., Pardo, C., Vargas, D., Nath, A. Novel markers of oxidative stress in actively progressive HIV dementia. J Neuroimmunol 2004157:176-184.

McArthur, J.C., McDermott, M., McClernon, D., St Hillaire, C., Conant, K., Marder, K., Schifitto, G., Selnes, O.A., Sacktor, N., Stern, Y., Albert, S., Palumbo, D., Kieburtz, K., deMarcaida, J.A., Cohen, B., Epstein, L.G. Attenuated CNS infection in advanced HIV/AIDS with highly active antireteroviral therapy. Arch Neurol 2004;61:1687-1696.

Valcour, V., Shikuma, C., Shiramizu, B., Watters, M., Poff, P., Selnes, O., Holck, P., Grove, J., Sacktor, N. Higher frequency of dementia in older HIV+ individuals. The Hawaii Aging with HIV Cohort. Neurology 2004;63:822-827.

Valcour, V., Shikuma, C., Watters, M., Sacktor, N. Cognitive impairment in older HIV-1 seropositive individuals: prevalence and potential mechanisms. AIDS 2004; 18:S79-S86.

Sacktor, N., Skolasky, R.L., Tarwater, P.M., McArthur, J.C., Selnes, O., Becker, J., Cohen, B., Visscher, B., Miller, E., for the Multicenter AIDS Cohort Study. Response to systemic HIV viral load suppression correlates with psychomotor speed performance. Neurology 2003;61:567-569.

Marder, K., Albert, S., McDermott, M.P., McArthur, J., Schifitto, G., Selnes, O.A., Sacktor, N., Stern, Y., Palumbo, D., Kieburtz, K., Cohen, B., Orme C., Epstein, L. Inter-rater Reliability of a Modification of the Memorial Sloan Kettering Staging of HIV Associated Cognitive Impairment. Neurology 2003;60:1467-1473.

Sacktor, N. The epidemiology of HIV-associated neurological disease in the era of highly active antiretroviral therapy. J Neurovirology 2002;8(S2):115-121.

Sacktor, N., McDermott, M.P., Marder, K., Schifitto, G., Selnes, O.A., McArthur, J.C., Stern, Y., Albert, S., Palumbo, D., Kieburtz, K., Marcaida, J., Cohen, B., Epstein, L. HIV-associated cognitive impairment before and after the advent of combination therapy. J Neurovirology 2002;8:136-142.