Center for Global Health Faculty

Professor

Academic Degrees

• MD

Departmental Affiliation

• Name:

  International Health

  Affiliation Type:

  Primary

  Division:

  Global Disease Epidemiology and Control

• Name:

  Epidemiology

  Affiliation Type:

  Joint

Departmental Address

Contact Information

Email:

dsack+jhsph.edu

Phone:

443-287-8795

Fax:

410-502-6733

Link:

SciVal Experts Research Profile

Research and Professional Experience

My research has been focused on enteric infections and vaccine development for these infections.

With regard to enteric infections, this has included laboratory detection of these agents, describing their epidemiology in travelers and developing country populations, developing appropriate clinical management strategies including antibiotics and rehydration methods.

With regard to vaccines, I have participated in the development of vaccines for cholera, rotavirus, enterotoxigenic E coli, shigellosis and other bacterial infections.

More recently, I have developed new lab diagnositics for detecting active tuberculosis (as opposed to latent TB), and have been involved in studies of the epideiology of malaria in Bangladesh

Keywords

International Health, cholera, rotavirus, diarrhea, Bangladesh, Gates Award, enterotoxigenic Escherichia coli, shigella, International Center, population, epidemiology, oral rehyration solution, malaria, tuberculosis

Honors and Awards

Gates Award for Global Health for the ICDDRB

Independence Day Award for the ICDDRB

Selected Publications

1. Alam DS, Yunus M, El Arifeen S, Chowdury HR, Larson CP, Sack DA, Baqui AH, Black RE. Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children. J Nutr. 2011 Feb;141(2):312-5. Epub 2010 Dec 8. PubMed PMID: 21147907.
2. Thomas T, Brighenti S, Andersson J, Sack D, Raqib R. A new potential biomarker for childhood tuberculosis. Thorax. 2011 Jan 12. [Epub ahead of print] PubMed PMID: 21228421.
3. Rekha RS, Kamal SM, Andersen P, Rahim Z, Hoq MI, Ara G, Andersson J, Sack D, Raqib R. Validation of the ALS assay in adult patients with culture confirmed pulmonary tuberculosis. PLoS One. 2011 Jan 21;6(1):e16425. PubMed PMID: 21283655; PubMed Central PMCID: PMC3025031.
4. Larson CP, Koehlmoos TP, Sack DA; the Scaling Up of Zinc for Young Children (SUZY) Project Team. Scaling up zinc treatment of childhood diarrhoea in Bangladesh: theoretical and practical considerations guiding the SUZY Project.Health Policy Plan. 2011 Feb 22. [Epub ahead of print] PubMed PMID: 21343236.
5. Sack DA. How many cholera deaths can be averted in Haiti? Lancet. 2011 Mar 15.[Epub ahead of print] PubMed PMID: 21414660.
6. Nelson EJ, Nelson DS, Salam MA, Sack DA. Antibiotics for Both Moderate and Severe Cholera. N Engl J Med. 2010 Dec 9. [Epub ahead of print] PubMed PMID:21142691.
7. Bardhan P, Faruque AS, Naheed A, Sack DA. Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia. Emerg Infect Dis. 2010 Nov;16(11):1718-23. Review. PubMed PMID: 21029529.
8. Gidudu J, Sack DA, Pina M, Hudson MJ, Kohl KS, Bishop P, Chatterjee A, Chiappini E, Compingbutra A, da Costa C, Fernandopulle R, Fischer TK, Haber P, Masana W, de Menezes MR, Kang G, Khuri-Bulos N, Killion LA, Nair C, Poerschke G,  Rath B, Salazar-Lindo E, Setse R, Wenger P, Wong VC, Zaman K; The Brighton Collaboration Diarrhea Working Group. Diarrhea: Case definition and guidelines for collection, analysis, and presentation of immunization safety data. Vaccine.  2010 Dec 3. [Epub ahead of print] PubMed PMID: 21130754.
9. Fischer Walker CL, Sack D, Black RE. Etiology of diarrhea in older children, adolescents and adults: a systematic review. PLoS Negl Trop Dis. 2010 Aug 3;4(8):e768. PubMed PMID: 20689809.
10. Zaman K, Dang DA, Victor JC, Shin S, Yunus M, Dallas MJ, Podder G, Vu DT, Le TP, Luby SP, Le HT, Coia ML, Lewis K, Rivers SB, Sack DA, Schödel F, Steele AD, Neuzil KM, Ciarlet M. Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial. Lancet. 2010 Aug 21;376(9741):615-23. Epub 2010 Aug 6. PubMed PMID: 20692031
11. Lyon CE, Sadigh KS, Carmolli MP, Harro C, Sheldon E, Lindow JC, Larsson CJ, Martinez T, Feller A, Ventrone CH, Sack DA, DeNearing B, Fingar A, Pierce K, Dill EA, Schwartz HI, Beardsworth EE, Kilonzo B, May JP, Lam W, Upton A, Budhram R and Kirkpatrick BD. In a randomized, double-blinded, placebo-controlled trial, the single oral dose typhoid vaccine, M01ZH09, is safe and immunogenic at doses up to 1.7 x 10(10) colony-forming units. Vaccine 28: 3602-3608, 2010.
12. Siddique AK, Nair GB, Alam M, Sack DA, Huq A, Nizam A, Longini IM, Jr., Qadri F, Faruque SM, Colwell RR, Ahmed S, Iqbal A, Bhuiyan NA and Sack RB. El Tor cholera with severe disease: a new threat to Asia and beyond. Epidemiol Infect 138: 347-352, 2010.
13. Nelson EA, Sack D, Wolfson L, Walker DG, Seng LF, Steele D. Financing children's vaccines. Vaccine. 2009 Nov 20;27 Suppl 5:F12-7. PubMed PMID: 19931710. 
14. Zaman K, Yunus M, Faruque AS, El Arifeen S, Hossain I, Azim T, Rahman M, Podder G, Roy E, Luby S, Sack DA. Surveillance of rotavirus in a rural diarrhoea  treatment centre in Bangladesh, 2000-2006. Vaccine. 2009 Nov 20;27 Suppl 5:F31-4. PubMed PMID: 19931715.
15. Luby SP, Brooks WA, Saha SK, el-Arifeen S, Naheed A, Sack D, Breiman RF. Use of multiple surveillance modalities to assess the epidemiology of Streptococcus pneumoniae infection in Bangladesh. Clin Infect Dis. 48 Suppl 2:S97-102, 2009.
16. Sack DA, Brooks V, Behan M, Cravioto A, Kennedy A, Ijsselmuiden C, Sewankambo  N. Improving international research contracting. Bull World Health Organ. 87:487-487A, 2009.
17. Naheed A, Saha SK, Breiman RF, Khatun F, Brooks WA, El Arifeen S, Sack D, Luby SP; Pneumococcal Study Group. Multihospital surveillance of pneumonia burden among children aged <5 years hospitalized for pneumonia in Bangladesh. Clin Infect Dis. 48 Suppl 2:S82-9, 2009 .
18. Raqib R, Mondal D, Karim MA, Chowdhury F, Ahmed S, Luby S, Cravioto A, Andersson J, Sack D. Detection of antibodies secreted from circulating Mycobacterium tuberculosis-specific plasma cells in the diagnosis of pediatric tuberculosis. Clin Vaccine Immunol. 16:521-7, 2009.
19. Zaman K, Sack DA, Yunus M, Arifeen SE, Podder G, Azim T, Luby S, Breiman RF,Neuzil K, Datta SK, Delem A, Suryakiran PV, Bock HL; Bangladeshi Rotavirus Vaccine study group. Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age. Vaccine. 27:1333-9, 2009.
20. Sack DA, Qadri F, Svennerholm A-M. Determinants of Responses to Oral Vaccines in Developing Countries Ann Nestlé [Engl] 2008;66:71–79
21. Sack DA. Achieving the millennium development goals for health and nutrition in Bangladesh: key issues and interventions--an introduction. J Health Popul Nutr. 26:253-60, 2008.
22. Ali M, Emch M, Yunus M, Sack D, Lopez AL, Holmgren J, Clemens J. Vaccine Protection of Bangladeshi infants and young children against cholera: implications for vaccine deployment and person-to-person transmission. Pediatr Infect Dis J. 27:33-7,2008