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Center for Global Health Faculty

Dolores Njoku

Program Director, The Fellowship in Pediatric Anesthesiology

Academic Degrees

Departmental Address

Blalock 906A

Contact Information

Phone:
410-614-5173
Link:
SciVal Experts Research Profile

Research and Professional Experience

immune-mediated drug-induced liver injury, autoimmune myocarditis, autoimmune thyroiditis

Keywords

drug-haptens, hepatitis, myocarditis

Selected Publications

1: Njoku DB, Li Z, Washington ND, Mellerson JL, Talor MV, Sharma R, Rose NR. Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury. Eur J Immunol. 2009 Jun;39(6):1652-63. PubMed PMID: 19499520.

2: Njoku DB, Li Z, Mellerson JL, Sharma R, Talor MV, Barat N, Rose NR. IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis. J Autoimmun. 2009 Feb;32(1):52-9. Epub 2009 Jan 7. PubMed PMID: 19131211; PubMed Central PMCID: PMC2661104.

3: Chin MW, Njoku DB, MacQuillan G, Cheng WS, Kontorinis N. Desflurane-induced acute liver failure. Med J Aust. 2008 Sep 1;189(5):293-4. PubMed PMID: 18759731.

4: Nguyen C, Rose NR, Njoku DB. Trifluoroacetylated IgG4 antibodies in a child with idiosyncratic acute liver failure after first exposure to halothane. J Pediatr Gastroenterol Nutr. 2008 Aug;47(2):199-202. PubMed PMID: 18664874.

5: Anderson JS, Rose NR, Martin JL, Eger EI, Njoku DB. Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesth Analg. 2007 Jun;104(6):1452-3, table of contents. PubMed PMID: 17513640.

6: Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR, Fairweather D. Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunol. 2006 Jun 1;176(11):6411-5. PubMed PMID: 16709797.

7: Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF, Kaya Z, Yusung SA, Davis SE, Frisancho JA, Barrett MA, Rose NR. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart. J Immunol. 2006 Mar 15;176(6):3516-24. PubMed PMID: 16517720.

8: Njoku DB, Mellerson JL, Talor MV, Kerr DR, Faraday NR, Outschoorn I, Rose NR. Role of CYP2E1 immunoglobulin G4 subclass antibodies and complement in pathogenesis of idiosyncratic drug-induced hepatitis. Clin Vaccine Immunol. 2006 Feb;13(2):258-65. PubMed PMID: 16467335; PubMed Central PMCID: PMC1391926.

9: Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA, Rose NR. A novel model of drug hapten-induced hepatitis with increased mast cells in the BALB/c mouse. Exp Mol Pathol. 2005 Apr;78(2):87-100. Epub 2005 Jan 6. PubMed PMID: 15713433.

      
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