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Center for Global Health Faculty

Greg Riggins, MD and PhD, Emory University, 1994

Director, Division of Neurosurgery Research

Contact Information

CRB2 rm 257
1550 Orleans Street
410-502-2905
410-502-5559

Personal website : http://www.hopkinsneuro.org/research/RigginsLab/index.cfm

SciVal Experts Research Profile

Education

MD and PhD, Emory University, 1994

Overview

Our laboratory uses genomics and molecular biology to locate and analyze genes that are altered during cancer development. We focus primarily on brain cancers, but our international collaborations focus on many cancer types, in particular those most relevent to the host country. Our general approach is to determine which genes are mutated, and which pathways are pathologically activated during malignant progression and to target these pathways with small molecules and small molecule combination. With our international collaborations we work to apply advanced genomics to cancers of interest, train scientists, and to create projects that address special needs.

Honors and Awards

Irving J. Sherman, M.D. Research Professor of Neurosurgery, Johns Hopkins University SOM

  • Cancer Genomics
  • Brain Cancers
  • New cancer therapy development
  • 28. Beaty RM, Edwards JB, Boon K, Siu IM, Conway JE, and Riggins GJ. PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium. J Neurooncol. 2007; 81: 241-8. 29. Trembath DG, Lal A, Kroll DJ, Oberlies NH, Riggins GJ. A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII. Mol Can. 2007; 6:30. 30. Sawanyawisuth K, Wongkham C, Pairojkul C, Saeseow OT, Riggins GJ Araki N, and Wongkham S. Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma. Acta Oncol. 2007; 46(3): 378-85. 31. Cerutti J., Oler G., Michaluart P., Delcelo R., Beaty R., Shoemaker J., and Riggins GJ. Molecular Profiling of Matched Samples Identifies Biomarkers of Papillary Thyroid Carcinoma Lymph Node Metastasis. Cancer Research 2007; 67 (16):7885-92. 32. Avarez H, Corvalan A, Roa JC, Argani P, Murillo F, Edwards, J, Beaty R, Feldmann G, Hong SM, Mullendore M, Roa I, Ibañez L, Pimentel F, Diaz A, Riggins GJ, Maitra A. Serial analysis of gene expression identifies connective tissue growth factor expression as a prognostic biomarker in gallbladder cancer. Clin Cancer Res. 2008; 14(9):2631-8. 33. Latini FR, Hemerly JP, Oler G, Riggins GJ, Cerutti JM. Re-expression of AB13-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. Endocr Relat Cancer 2008; 15(3):787-799. 34. Oler G, Camacho CP, Hojaij FC, Michaluart P Jr, Riggins GJ, Cerutti JM. Gene expression profiling of papillary thyroid carcinoma identifies transcripts correlated with BRAF mutational status and lymph node metastasis. Clin Cancer Res. 2008 1; 14(15):4735-42. 35. Siu IM, Bai R, Gallia GL, Edwards JB, Tyler BM, Eberhart CG, Riggins GJ. Coexpression of neuronatin splice forms promotes medulloblastoma growth. Neuro Oncol. 2008;10(5):716-24. 36. Camacho CP, Latini FR, Oler G, Hojaij FC, Maciel RM, Riggins GJ, Cerutti JM. Down-regulation of NR4A1 in follicular thyroid carcinomas is restored following lithium treatment. Clin Endocrinol 2008 Aug 22. 37. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolsky Y, Busam DA, TEkleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. An integrated genomic analysis of human glioblastoma multiforme. Science 2008; 321(587):1807-12. 38. Rand V, Prebble E, Ridley L, Howard M, Wei W, Brundler MA, Fee BE, Riggins GJ, Coyle B, Grundy RG. Investigation of chromosome 1q reveals differential expression of members of the S100 family in clinical subgroups of intracranial paediatric ependymoma. Br J Cancer 2008; 99(7):1136-43. 39. Yi JM, Tsai HC, Glockner SC, Lin S. Ohm JE, Easwaran H, James CD, Costello JF, Riggins GJ , Eberhart CG, Laterra J, Vescovi AL, Ahuja N, Herman JG, Schuebel KE, Baylin SB. Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer Res. 2008; 68(19):8094-103. 40. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. IDH1 and IDH2 Mutations in Gliomas. N Engl J Med. 2009; 360(8):765-773. 41. Gallia GL, Tyler BM, Hann CL, Siu IM, Giranda VL, Vescovi AL, Brem H, Riggins GJ. Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells. Mol Cancer Ther. 2009 Feb;8(2):386-93. Epub 2009 Feb 10 42. Loilome W, Joshi AD, Ap Rhys CM, Piccirillo S, Angelo VL, Gallia GL, Riggins GJ. Glioblastoma cell growth is suppressed by disruption of fibroblast growth factor pathway signaling. J. Neurooncol. 2009 April 2. [Epub ahead of print] 43. Duncan CG, Leary RJ, Lin JC, Cummins J, Di C, Schaefer CF, Wang TL, Riggins GJ, Bigner D, Kopelovich L, Vogelstein B, Kinzler, KW, Velculescu VE, Yan H. Identification of microbial DNA in human cancer. BMC Med Genomics 2009 May 8;2:22

      
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