Selected Publications
Laeyendecker O, Brookmeyer R, Oliver AE, Mullis C, Eaton K, Mueller AC, Jacobson LP, Margolick JB, Brown J, Rinaldo CR, Quinn TQ, Eshleman SH. Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassay. In Press AIDS Research and Human Retroviruses.
Cousins M, Laeyendecker O, Beauchamp G, Brookmeyer R, Towler W, Hudelson SE, Khaki L, Koblin B, Chesney M, Moore RD, Kelen G, Coates T, Celum C, Buchbinder SP, Sheppard H, Seage G, Quinn TC, Donnell D, and Eshleman SH. Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infection. PLoS ONE 2011; 6(10): e27211.
Laeyendecker O, Latimore A, Eshleman SH, Summerton J, Oliver AE, Gamiel J, Dobbs T, Mei J, Murphy G, Parry JV, Owen SM, Quinn TC. The Effect of Sample Handling on Cross Sectional Incidence Testing Results. PLoS ONE 2011; 6(10): e25899.
Ng OT, Eyzaguirre LM, Carr JK, Chew KK, Lin L, Chua A, Leo YS, Redd AD, Quinn TC, Laeyendecker O. Identification of New CRF50_01B in Singapore Using Full Genome Analysis of Three HIV Type 1 Isolates. In Press AIDS Research and Human Retroviruses.
Piwowar-Manning E, Fiamma A, Laeyendecker O, Kulick M, Donnell D, Szekeres G, Robins-Morris L, Mullis CE, Vallari A, Hackett, Jr. J, Gray G, Richter L, Mbwambo J, Chariyalertsak S, Chingono A, Sweat M, Coates T, and Eshleman SH. HIV Surveillance and Cross-Sectional HIV Incidence Assessment in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043). BMC Infect Dis. 2011; 11: 251.
Galiwango RM, Lamers SL, Redd AD, Manucci J, Tobian AAR, Sewankambo N, Kigozi G, Nakigozi G, Serwadda D, Boaz I, Nalugoda F, Sullivan DJ, Wawer MJ, Gray RH, Quinn TC, and Laeyendecker O on behalf of the Rakai Health Sciences Program. HIV-1 genetic variation in foreskin and blood from subjects in Rakai, Uganda. In Press AIDS Research and Human Retroviruses
Shirreff G, Lorenzo Pellis L, Laeyendecker O, Fraser C. Transmission selects for HIV-1 strains of intermediate virulence: a model-based analysis. In Press PLoS Comp Biol.
Redd AD, Collinson-Streng A, Martens C, Ricklef S, Mullis CE, Manucci J, Tobian AAR, Selig EJ, Laeyendecker O, Sewankambo N, Gray RH, Serwadda D, Wawer MJ, Porcella SF, and Quinn TC on behalf of the Rakai Health Sciences Program. Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda using Next Generation deep sequencing. In Press, J. Clin. Micro.
Ssebugenyi I, Kizza A, Mpoza B, Aluma G, Iga Boaz I, Newell K, Laeyendecker O, Shott JP, Serwadda D, Reynolds SJ. Comparison of the Abbott Real-Time and Roche Amplicor v1.5 Monitor HIV-1 Viral Load Assays on Plasma Specimens from the Rakai Cohort, Uganda. Int J STD AIDS. 2011;22:373-5.
Neal JD, Tobian AAR, Laeyendecker O, Ngo TD , Redd AD, Reynolds SJ, Morrow RA, Jordyn L. Gamiel JL, David Serwadda D, Gray RH, and Quinn TC. Performance of Euroline Western Blot Assay in the Detection of Herpes Simplex Virus type 2 Antibody in Uganda, China, and the United States. . Int J STD AIDS. 2011 22:342-4.
Spacek LA, Lutwama F, Shihab HM, Summerton J, Kamya MR, Ronald A, Laeyendecker O, Quinn TQ, Mayanja-Kizza H. Diagnostic accuracy of ultrasensitive heat-denatured HIV-1 p24 antigen in non-B subtypes in Kampala, Uganda. Int J STD AIDS. 2011 Jun;22(6):310-4.
Redd AD, Laeyendecker O, Kong X, Kiwanuka N, Lutalo T, Huang W, Gray RH, Wawer MJ, Serwadda D, Eshleman SH, and Thomas C Quinn TC, on behalf of the Rakai Health Sciences Program. Changes in HIV-1 CCR5 replication efficiency and its effects on disease progression in Rakai district, Uganda. AIDS Res Hum Retroviruses. In Press AIDS Research and Human Retroviruses. 2011 Jun 10. [Epub ahead of print].
Incidence Assay Critical Path Working Group. More and Better Information to Tackle HIV Epidemics: Towards Improved HIV Incidence Assays. (Laeyendecker O, member Incidence Assay Critical Path Working Group). PLoS Med 8(6): e1001045. doi:10.1371/journal. pmed 1001045.
Stabinski L, Reynolds SJ, Ocama P, Laeyendecker O, Gray RH, Wawer MJ, Thomas DL, T.C. Quinn TC, Kirk GD on behalf of the Rakai Health Sciences Program. High Prevalence of Unexplained Liver Fibrosis Associated with HIV in Rural Southwestern Uganda. In Press Antiviral Therapy. Antivir Ther. 2011;16(3):405-11.
Taha TE, James MM, Hoover DR, Sun J, Laeyendecker O, Mullis C, Kumwenda JJ, Lingappa J, Auvert B, Morrison CS, Mofensen LM, Taylor A, Fowler MG, Kumenda NI, and Eshleman SH. Women identified as recently infected at the time of delivery using a multi-assay algorithm for HIV incidence had a higher rate of in utero HIV transmission: Findings from the PEPI-Malawi trial. AIDS. 2011; 25:1357-1364
Eller MA, Blom KG, Gonzalez VD, Eller LE, Naluyima P, Laeyendecker O, Quinn TC, Kiwanuka N, Serwadda D, Sewankambo NK, Tasseneetrithep B, Wawer MJ, Gray RH, Marovich MA,2 Michael NL, de Souza MS, Wabwire-Mangen F, Robb ML, Currier JR, and Sandberg JK. CD38, HLA-DR, and PD-1 Together Define Pathogenic CD4 T Cell Immune Activation in Chronic HIV-1 Infection. PLoS One. . 2010 Volume 6 | Issue 4 | e18779.
Stabinski L, Reynolds SJ, Ocama, Serwadda D, Quinn TC, Thomas DL, Laeyendecker O, Wawer MJ, Gray RH, Kirk GD. Sexual Behavior and HBV Infection among the Highly Susceptible Adult Population of Rakai, Uganda. Journal of Medical Virology. 2011; 83:796-800.
Ng O-T, Munshaw S, Lamers SL, Chew K-K, Lin L, Redd AD, Manucci J, Quinn TC, Ray SC, Chua A, Leo YS, Laeyendecker O. Molecular Epidemiology of HIV-1 in Singapore and Identification of Novel CRF01_AE/B Recombinant Forms. In Press AIDS Res Hum Retroviruses. [Epub ahead of print].
Ng O-T, Lin L, Laeyendecker O, Quinn TC, Sun Y-J, Lee C-C, Leo Y-S. Increased Rates of CD4+ T-cell Decline and Faster Time to Antiretroviral Therapy Initiation in HIV-1 Subtype AE Infected Seroconverters in Singapore. PLoS One. 2011; 6(1): e15738
Aumakhan B, Hardick A, Quinn TC, Laeyendecker O, Gange SJ, Beyrer C, Cox C, Anastos K, Cohen M, Greenblatt RM, Merenstein DJ, Minkoff H, Nowicki M, Gaydos CA.Genital Herpes Evaluation by Quantitative TaqMan PCR: Correlating Single Detection and Quantity of HSV-2 DNA in Cervicovaginal Lavage Fluids with Cross-sectional and Longitudinal Clinical Data. Virology Journal 2010, 7:328.
Mastro TD, Kim A, Hallett T, Rehle T, Welte A, Laeyendecker O, Oluoch T, Garcia-Calleja JM. Estimating HIV Incidence in Populations: Issues, Challenges and the Way Forward. Journal of HIV/AIDS Surveillance and Epidemiology. 2010;2(1):7.
Laeyendecker O, Church JD, Oliver AE, Mwatha A, Owen SM, Donnell D, Brookmeyer, Musoke P, Jackson JB, Laura Guay L, Nakabiito C, Quinn TC, and Eshleman SH. Pregnancy does not affect HIV incidence test results obtained using the BED capture enzyme immunoassay or an antibody avidity assay. PLoS One. 2010 Volume 5 | Issue 10 | e13259
Conroy SA#, Laeyendecker O#, Redd AD, Collinson-Streng A, Kong X, Makumbi F, Lutalo T, Sewankambo N, Kiwanuka N, Gray RH, Wawer MJ, Serwadda D, and Quinn TC. Changes in the distribution of HIV-1 subtypes D and A in Rakai District, Uganda between 1994 and 2002. AIDS Res Hum Retroviruses. 2010; 10 , 1087-91.
Lucas GM, Clarke W, Kagaayi J, Atta MG, Fine DM, Laeyendecker O, Serwadda D, Chen M, Wawer MJ, and Gray RH. Decreased kidney function in a community-based cohort of HIV-infected and HIV-negative individuals in Rakai, Uganda. J Acquir Immune Defic Syndr. 2010 Dec 1;55(4):491-4.
Polis CB, Wawer MJ, Kiwanuka N, Laeyendecker O, Kagaayi J, Lutalo T, Nalugoda F, Kigozi G Serwadda D, Gray RH. Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda. AIDS. 2010 Jul 31;24(12):1937-44.
Welte A, McWalter TA, Laeyendecker O, and Hallet TB. Using Tests for Recent Infection to Estimate Incidence: Problems and Prospects for HIV. Eurosurveillance 2010: 15; Issue 24, Article 4, pii: 19589.
Redd AD, Eaton KP, Kong X, Laeyendecker O, Wawer MJ, Gray RH, Serwadda D, and Quinn TC on behalf of the Rakai Health Sciences Program. C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation. J Acquir Immune Defic Syndr. 2010 54:556-559.
Fiamma A, Lissouba P, Oliver AE, Laeyendecker O, Quinn TC, Taljaard D, Puren A, Auvert B. Can HIV incidence testing be used for evaluating HIV intervention programs? BMC Infect Dis. 2010;10:137-146.
Hollingsworth TD, Laeyendecker O, Shirreff G, Donnelly CA, Serwadda D, Wawer MJ, Kiwanuka N, Nalugoda F, Collinson-Streng A, Ssempijja V, Hanage WP, Quinn TC, Gray RH, and Fraser C. HIV-1 transmitting couples have similar viral load set-points in Rakai, Uganda. PLoS Pathog 6(5): e1000876.
Gray RH, Serwadda D, Kong X, Makumbi F, Kigozi G, Gravitt PE, Watya S, Nalugoda F, Ssempijja V, Tobian AA, Kiwanuka N, Moulton LH, Sewankambo NK, Reynolds SJ, Quinn TC, Boaz Iga B, Laeyendecker O, Oliver AE, and Wawer MJ. Male circumcision decreases acquisition and increases clearance of high risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda. J Infect Dis. 2010; 201:1455-62.
Serwadda D, Wawer MJ, Makumbi F, Kong X, Kigozi G, Gravitt PE, Watya S, Nalugoda F, Ssempijja V, Tobian AAR, Kiwanuka N, Moulton LH, Sewankambo NK, Reynolds SJ, Quinn TC, Oliver AE, Iga B, Laeyendecker O, Gray RH. Circumcision of HIV-infected men: Effects on High Risk Human Papillomavirus Infections in a Randomized Trial in Rakai, Uganda. J Infect Dis. 2010;201:1463-9.42.
Kiwanuka N, Robb M, Laeyendecker O, Kigozi G, Wabwire-Mangen F, Nalugoda F, Kagaayi J, McCutchan F, Eller MA, Eller LA, Serwadda D, Sewankambo NK, Reynolds SJ, Quinn TC, Wawer MJ, and Gray RH. HIV-1 viral subtype differences in the rate of CD4+ T cell decline among HIV seroincident antiretroviral naïve persons in Rakai district, Uganda. J Acquir Immune Defic Syndr. 2010; 54: 180–184.
