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Center for Global Health Faculty

Aynur Unalp-Arida

Associate Scientist

Aynur Unalp-Arida

Academic Degrees

  • MD
  • PhD
  • MSc

Departmental Affiliation

Departmental Address

615 North Wolfe Street, Room W5010 Baltimore, MD 21205

Contact Information

Phone:
410-614-4851
Fax:
410-955-0932

Research and Professional Experience

Current projects include:

Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating Center to conduct multicenter clinical trials, epidemiological, and therapeutic research in nonalcoholic fatty liver disease (NAFLD) and NASH patients

Gastroparesis Clinical Research Consortium Data Coordinating Center to conduct multicenter clinical trials and observational studies to investigate the etiology, natural history, and management of gastroparesis

Preservation of Vascular Access Study (PVAS) Coordinating Center to conduct a retrospective, observational study designed to evaluate the use of SyvekPatch®, manufactured by the MPT, in extending the life of arteriovenous (AV) fistulas and AV grafts in hemodialysis patients

Keywords

clinical epidemiology, clinical trials, drug approval

nonalcoholic steatohepatitic (NASH), nonalcoholic fatty liver disease (NAFLD), gastroparesis

Honors and Awards

Doctoral Fellowship, 1994-99, The Turkish Higher Education

Council Postdoctoral Training Grant, 1999-00, The Johns Hopkins Center for Clinical Trials

Selected Publications

Juluri R, Vuppalanchi R, Olson J, Unalp A, Van Natta ML, Cummings OW, Tonascia J, Chalasani N. Generalizability of the Nonalcoholic Steatohepatitis Clinical Research Network Histologic Scoring System for Nonalcoholic Fatty Liver Disease. J Clin Gastroenterol 2010 May 25. [Epub ahead of print]

Patton HM, Yates K, Ünalp-Arida A, Behling CA, Huang TT-K, Rosenthal P, Sanyal AJ, Schwimmer JB, and Lavine JE for the NASH CRN. Association between metabolic syndrome and liver histology among children with NAFLD. Am J Goastroenterol 2010 April 6 [Epub ahead of print].

Writing Committee member. Sanyal AJ, Chalasani NP, Kowdley KV, McCullough AJ, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Ünalp A, Van Natta ML, Clark JM, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR. Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis: PIVENS Trial Primary Results. N Engl J Med 362: 1675-1685, 2010.

Abdelmalek MF, Suzuki A, Guy G, Ünalp-Arida A, Colvin R, Johnson RJ, Diehl AM. Increased Fructose Consumption is Associated with Fibrosis Severity in Patients with NAFLD. Hepatology 51: 1961-1971, 2010.

Kistler KD, Molleston JP, Ünalp A, Abrams SH, Behling C, Schwimmer JB, and the NASH CRN Research Group. Symptoms and Quality of Life in Obese Children and Adolescents with Nonalcoholic Fatty Liver Disease. Aliment Pharmacol Ther 31: 396-406, 2010

Writing Committee member (Lavine JE, Schwimmer JB, Molleston JP, Scheimann AO, Murray KF, Abrams SH, Rosenthal P, Sanyal AJ, Robuck PR, Brunt EM, Ünalp A, Tonascia J) for the NASH CRN. Treatment of non-alcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials 31: 62-70, 2010.

Ünalp A, Ploth DW, Colvin R, Counts C, Shepp PH, Van Natta ML, Meinert CL. Does Poly-N-Acetyl Glucosamine Patch Use Reduce Arteriovenous Fistula and Graft Failure Rates in Hemodialysis Patients with End Stage Renal Disease? Am J Med Sci 338: 178-184, 2009

David K, Kowdley KV, Ünalp A, Kanwal F, Brunt EM, Schwimmer JB; NASH Clinical Research Network. Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network. Hepatology 49: 1904-1912, 2009.

Vuppalanchi R, Ünalp A, Natta ML, Cummings OW, Sandrasegaran KE, Hameed T, Tonascia J, Chalasani N. Effects of Liver Biopsy Sample Length and Number of Readings on Histologic Yield for Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol 7: 481-486, 2009.

Brunt EM, Kleiner DE, Wilson LA, Ünalp A, Behling CE, Lavine JE, Neuschwander-Tetri BA; NASH Clinical Research Network. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): A histologic marker of advanced NAFLD - clinicopathologic correlations from the Nonalcoholic Steatohepatitis Clinical Research Network. Hepatology 49: 809-820, 2009.

Writing Committee member (Chalasani NP, Sanyal AJ, Kowdley KV, Robuck PR, Hoofnagle J, Kleiner DE, Ünalp A, Tonascia J) for the NASH CRN. Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials 30: 88-96, 2009.

Chalasani N, Wilson L, Kleiner DE, Cummings OW, Brunt EM, Ünalp A; for the NASH Clinical Research Network. Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease. J Hepatol 48: 829-834, 2008.

Neuschwander-Tetri BA, Ünalp A, Creer MH; Nonalcoholic Steatohepatitis Clinical Research Network. Influence of local reference populations on upper limits of normal for serum alanine aminotransferase levels. Arch Intern Med 168: 663-666, 2008.

Ünalp A, Tonascia S, Meinert CL. Presentation in relation to publication of results from clinical trials. Contemp Clin Trials 28: 358-369, 2007.

Erkan D, Harrison MJ, Levy R, Peterson M, Petri M, Sammaritano L, Unalp-Arida A, Vilela V, Yazici Y, Lockshin MD. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome. Arthritis Rheum 56: 2382-2391, 2007.

Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp-Arida A, Yeh M, McCullough AJ, Sanyal AJ for the Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313-1321, 2005

Heath EI, Canto MI, Wu TT, Piantadosi S, Hawk E, Ünalp A, Gordon G, Forastiere AA; CBET Research Group. Chemoprevention for Barrett's esophagus trial: Design and outcome measures. Dis Esophagus 16:177-186, 2003

Unalp A, Shafer C, Tonascia S, Meinert CL. FDA censoring of manufacturers' postmarketing commitments in HIV/AIDS drug approval letters. Am J Ther 7: 257-263, 2000

Meinert CL, Gilpin AK, Unalp A, Dawson C. Gender representation in trials. Control Clin Trials 21: 462-475, 2000

Gencbay M, Degertekin M, Ermeydan C, Unalp A, Turan F. Exercise electrocardiography test in patients with aortic stenosis. Differential features from that of coronary artery disease. Int J Cardiol 69: 281-287, 1999

Gencbay M, Turan F, Degertekin M, Eksi N, Mutlu B, Unalp A. High prevalence of hypercoagulable states in patients with recurrent thrombosis of mechanical heart valves. J Heart Valve Dis 7: 601-609, 1998

Unalp-Arida A. Time lag bias in publishing clinical trials [letter]. JAMA 279: 1952, 1998

Unalp A, Ruacan S, Firat D. Hospital-based cancer registry. Turk J Cancer 24: 127-137, 1994

      
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