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Center for Global Health Faculty

Stephen J. Gange

Professor

Deputy Chair & Director, PhD/ScD Program

Stephen J. Gange

Academic Degrees

  • PhD

Departmental Affiliation

Departmental Address

615 N. Wolfe Street, E7638 Baltimore, MD 21205

Contact Information

Phone:
410-502-9771
Fax:
410-955-7587
Link:
Personal Website
Link:
SciVal Experts Research Profile

Research and Professional Experience

Research interests include epidemiologic and statistical methods for cohort studies, evaluation of therapies and biomarkers in observational studies, epidemiology and pathogenesis of HIV/AIDS and data management and statistical coordinating centers.

During the past 18 years, I have worked primarily in HIV/AIDS with experience that spans basic, clinical, epidemiological, and policy-level research including as:

  • PI of the data management and analysis center for the Women's Interagency HIV Study (WIHS), the largest nationwide cohort study devoted to the study of HIV-infected women.
  • Epidemiology/Biostatistics Core Director for the North American AIDS Cohort Collaboration of Research and Design (NA-ACCORD), an International Epidemiologic Databases to Evaluate AIDS (IeDEA) initiative. This collaboration has collected data on over 100,000 HIV-infected individuals across the US and Canada.
  • Biostatistics and Epidemiology Methods Core Director for the Johns Hopkins Center for AIDS Research (CFAR)
  • A co-investigator with:
    • HIV Susceptibility and Pathogenesis in the Female Genital Tract Program Project
    • The nationwide Multicenter AIDS Cohort Study
    • Johns Hopkins HIV Clinical Cohort Study
    • The Baltimore-based ALIVE Study

I addition to methodological and HIV/AIDS research, I have worked on studies of HPV, substance abuse, and molecular biomarkers for liver cancer with investigators across the University.

Keywords

Epidemiology, Methods, HIV, HIV/AIDS, Cohort Studies,Treatments,Biomarkers, Biostatistics, Data Management or Analysis (Medical), Observational Studies;

Honors and Awards

Invited Member, American Epidemiologial Society, 2012

Fellow, American College of Epidemiology, 2010

Faculty Senate, President, 2008-9.

Advising, Mentoring, and Teaching Recognition Award (AMTRA) from Student Assembly, Johns Hopkins School of Public Health, 2005.

Elected Member, Delta Omega Honorary Public Health Society, Alpha Chapter, Johns Hopkins School of Public Health, 2002.

AIDS Clinical Studies and Epidemiology Study Section, 2001-6.

Biometrics Society (ENAR) Student Travel Award, 1994. Paper also selected as one of top submissions.

Society of Clinical Trials Student Scholarship Travel Award, 1994.

Selected Publications

Click here for a complete list of Dr. Gange's PubMed citations.

2012 and forthcoming

Westreich D, Cole SR, Young JG, Palella F, Tien PC, Kingsley L, Gange SJ, Hernán MA. The parametric g-formula to estimate the effect of highly active antiretroviral therapy on incident AIDS or death. Stat Med. 2012

Hanna DB+, Selik RM, Tang T, Gange SJ.  Disparities among states in HIV-related mortality in persons with HIV infection, 2001-2007. AIDS 2012, 26:95–103.

Bambha K, Pierce C, Cox C, French AL, Tien PC, Sharp GB, Augenbraun M, Glesby MJ, Villacres MC, Plankey M, Strickler HD, Gange SJ, and Peters MG. Assessing Mortality in Women with Hepatitis C Virus and Human Immunodeficiency Virus using Indirect Markers of Fibrosis.  Accepted for publication, AIDS 2012.

Parrinello CM, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt PW, Deeks SG, Hodis HN, Kaplan RC. Cytomegalovirus IgG antibody is associated with subclinical carotid artery disease among HIV-infected women.  Accepted for publication, Journal of Infectious Diseases 2012.

Villacres MC, Kono N, Mack W, Nowicki MJ, Anastos K, Augenbraun M, Liu C, Landay A, Greenblatt R, Gange S, and Levine AM. IL10 responses are associated with sustained CD4 T cell counts in treated HIV infection. Accepted for publication, Journal of Infectious Diseases 2012.

Gandhi M, Greenblatt R, Bacchetti P, Jin C, Huang Y, Anastos K, Cohen M, DeHovitz JA, Sharp GB, Gange SJ, Liu C, Hanson SC, and Aouizerat B. A Single Nucleotide Polymorphism in CYP2B6 Leads to >3-fold Increases in Efavirenz Concentrations in Intensive PK Curves and Hair Samples. Accepted for publication, Journal of Infectious Diseases 2012.

Xie X, Xue X, Gange S, Strickler H, Kim M.  Estimation and inference on correlations between biomarkers with repeated measures and left-censoring due to minimum detection levels.  Accepted for publication, Statistics in Medicine.

2011

Abraham AG, Lau B, Deeks S, Moore RD, Zhang J, Eron J, Harrigan R, Gill MJ, Kitahata M, Klein M, Napravnik S, Rachalis A, Rodriguez B, Rourke S, Benson C, Bosch R, Collier A, Gebo K, Goedert J, Hogg R, Horberg M, Jacobson L, Justice A, Kirk G, Martin J, McKaig R, Silverberg M, Sterling T, Thorne J, Willig J, and Gange SJ.  Missing Data in the Estimation of the Prevalence of Accumulated HIV Drug Resistance in Antiretroviral-Treated Patients in North America. American Journal of Epidemiology 2011 Sep 15;174(6):727-35. 

Kuniholm MH, Gao X, Xue X, Kovacs A, Anastos K, Marti D, Greenblatt RM, Cohen MH, Minkoff H, Gange SJ, Fazzari M, Young MA, Strickler HD, Carrington M. Human Leukocyte Antigen (HLA) Genotype and Risk of HIV Disease Progression Before and After Initiation of Antiretroviral Therapy. J Virol. 2011 Aug 17.

Sterling TR, Lau B, Zhang J, Freeman A, Bosch RJ, Brooks JT, Deeks SG, French A, Gange S, Gebo KA, John Gill M, Horberg MA, Jacobson LP, Kirk GD, Kitahata MM, Klein MB, Martin JN, Rodriguez B, Silverberg MJ, Willig JH, Eron JJ, Goedert JJ,Hogg RS, Justice AC, McKaig RG, Napravnik S, Thorne J, Moore RD; for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (IeDEA). Risk Factors for Tuberculosis After Highly Active Antiretroviral Therapy Initiation in the United States and Canada: Implications for Tuberculosis Screening. J Infect Dis. 2011 Sep;204(6):893-901.

Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Parrinello CM, Hunt P, Deeks SG, and Hodis H. T-cell activation predicts carotid artery stiffness among HIV-infected. Atherosclerosis 2011 Jul;217(1):207-13. 

Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt P, Karim R, Kern DM, Hodis HN, Deeks SG. T-cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis. 2011 Feb;203(4):452-63

Lau B, Cole SR, Gange SJ.  Parametric mixture models to evaluate and summarize hazard ratios in the presence of competing risks with time-dependent hazards and delayed entry. Stat Med. 2011 Mar 15;30(6):654-65.

Aumakhan B+, Gange SJ, Beyrer C, Gaydos CA, Minkoff H, Merenstein DJ, Cohen M, Anastos A, Greenblatt R, Nowicki M, and Quinn TC. Quantitative and Qualitative Correlates of Cervicovaginal HSV-2 Shedding Among HIV Infected Women in Women’s Interagency HIV Study. Int J STD AIDS. 2011 May;22(5):273-7

Genberg BL+, Gange SJ, Go VF, Celentano D, Kirk G, Mehta SH. Trajectories of Injection Drug Use over 20 years (1988-2008) in Baltimore, Maryland. Am J Epidemiol 2011 Apr 1;173(7):829-36.

Nowak RG+, Gravitt PE, Morrison CS, Gange SJ, Kwok C, Oliver AE, Howard R, Van der Pol B, Salata R, Padian NS, Chipato T, Munjoma M, and Celentano DD. Increases in human papillomavirus (HPV) detection during early HIV infection among women in Zimbabwe. J Infect Dis. 2011 Apr;203(8):1182-91.

Gandhi M, Ameli N, Bacchetti P, Anastos K, Gange SJ, Minkoff H, Young M, Milam J, Cohen MH, Sharp GB, Huang Y, and Greenblatt RM. Atazanavir Concentration in Hair Is the Strongest Predictor of Outcomes on Antiretroviral Therapy Clin Infect Dis. 2011;52(10): 1267-1275

Kuniholm MH, Gao X, Xue X, Kovacs A, Marti D, Thio CL, Peters MG, Greenblatt RM, Goedert JJ, Cohen MH, Minkoff H, Gange SJ, Anastos K, Fazzari M, Young MA, Strickler HD, Carrington M. The Relation of HLA Genotype with Hepatitis C Viral Load and Markers of Liver Fibrosis in HIV-Infected and HIV-Uninfected Women. J Infect Dis. 2011 Jun;203(12):1807-14.

Huang YF, Kuo HS, Lew-Ting CY, Tian F, Yang SH, Tsai TI, Gange SJ, and Nelson KE. Mortality among a cohort of drug users after their release from prison: an evaluation of the effectiveness of a harm reduction program in Taiwan. Addiction 2011 Aug;106(8):1437-45.

Althoff KN+, Eichelberger M, Gange SJ, Sharp GB, Gao J, Glesby MJ, Young M, Greenblatt RM, French AL, Villacres MC, Minkoff H. Sero-incidence of 2009 H1N1 infection in HIV-infected and HIV-uninfected women in the US prior to vaccine availability. AIDS. 2011 Jun 1;25(9):1229-32.

Genberg BL+, Gange SJ, Go VF, Celantano DD, Kirk GD, Latkin CA, and Mehta SH. The Effect of Neighborhood Deprivation and Residential Relocation on Long-term Injection Cessation among Injection Drug Users (IDUs) in Baltimore, Maryland. Addiction 2011 Nov;106(11):1966-74.  

Keating SM, Golub ET, Nowicki M, Young M, Anastos K, Crystal H, Zhang J, Greenblatt RM, Desai S, Wu S, Landay AL, Gange SJ, and Norris PJ. The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of US women.  AIDS 2011 Sep;25(15):1823-32. 

Berry SA, Ghanem KG, Page KR, Gange SJ, Thio CL, Moore RD, Gebo KA. Increased gonorrhoea and chlamydia testing did not increase case detection in an HIV clinical cohort 1999-2007. Sex Transm Infect. 2011 Oct;84(6):469-75. 

Other recent significant work

Kitahata MM, Gange SJ, Abraham AG, Merriman B, Saag MS, Justice AC, Hogg RS, Deeks SG, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Goedert JJ, Benson CA, Collier AC, Van Rompaey SE, Crane HM, McKaig RG, Lau B, Freeman AM, Moore RD for the NA-ACCORD Investigators. Effect of early versus deferred antiretroviral therapy for HIV on survival. New England Journal of Medicine, 2009;360:1815-26. [With Editorial Commentary]

Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, Cranmer L, O'Shea A, Callender M, Spivak A, Brennan T, Kearney MF, Proschan MA, Mican JM, Rehm CA, Coffin JM, Mellors JW, Siliciano RF, Maldarelli F. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci (USA) 2009 Jun 9;106(23):9403-8. Epub 2009 May 22

Lau B, Cole SR, Gange SJ. Competing risk regression models for epidemiologic data. American Journal of Epidemiology 2009 Jul 15;170(2):244-56.

 

 

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