Center for Global Health Faculty

Professor

Director, CADDE

Academic Degrees

• PhD

Departmental Affiliation

• Name:

  Epidemiology

  Affiliation Type:

  Primary

  Division:

  Genetic Epidemiology

• Name:

  Biostatistics

  Affiliation Type:

  Joint

Departmental Address

Contact Information

Email:

dfallin+jhsph.edu

Phone:

410-955-3463

Fax:

410-955-0863

Link:

SciVal Experts Research Profile

Research and Professional Experience

I am interested in applying genetic epidemiology methods to studies of neuropsychiatric disorders including autism, Alzheimer's disease, schizophrenia, and bipolar disorder. I also work on the genetic predisposition to features affecting aging populations such as muscle strength and frailty.

In addition to these applied projects, I am interested in evaluating and improving methods for genetic analysis of population data. My research interests focus on methodology for population and family-based tests of genetic associations with human disease. I am also interested in building the field of epigenetic epidemiology, and work with the Center for Excellence in Genome Sciences focused on the epigenetic contributions to human disease.

Keywords

Epidemiology, genetics, SNP, genetic epidemiology, autism, schizophrenia, epigenetics

Selected Publications

Click here for a complete list of Dr. Fallin's publications

Li Q, Fallin MD, Louis TA, Lasseter VK, McGrath JA,  Avramopoulos D, Wolyniec PS, Valle D, Liang K-Y, Ruczinski I, Pulver AE. (2010) Detection of SNP-SNP Interactions in Trios of Parents with Schizophrenic Children. Genetic Epidemiology. In press

Fallin MD, Szymanski M, Wang R, Gherman A, Bassett SS, Avramopoulos D. (2010) Fine-mapping of the Chromosome 10q11-q21 Linkage Region in Alzheimer's Disease Cases and Controls. Neurogenetics, in press.

Matteini AM, Walston JD, Bandeen-Roche K, Arking DE, Allen RH, Fried LP, Chakravarti A, Stabler SP, Fallin MD. (2010) Transcobalamin-II Variants, Decreased Vitamin B12 Availability and Increased Risk of Frailty. J Nutr Health Aging, 14(1):73-7.

Fallin MD, Matteini AM. (2009) Genetic epidemiology in aging research. J Gerontol A Biol Sci Med Sci. 64(1):47-60.

*Bjornsson HT, *Sigurdsson MI, *Fallin MD, Irizarry RA, Aspelund T, Cui H, Yu W, Rongione MA, Ekström TJ, Harris TB, Launer LJ, Eiriksdottir G, Leppert MF, Sapienza C, Gudnason V, Feinberg AP. (2008) Intra-individual change over time in DNA methylation with familial clustering. JAMA. 299(24):2877-83. *These authors contributed equally.

Mulle JG, Fallin MD, Lasseter VK, McGrath JA, Wolyniec PS, Pulver AE. (2007)  Dense SNP association study for bipolar I disorder on chromosome 18p11 suggests two loci with excess paternal transmission. Mol Psychiatry. 12(4):367-75.

Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, Steel G, Nestadt G, Valle D, Liang KY, Huganir RL, Pulver AE. (2005) A 440-SNP Screen of 64 Candidate Genes Among Ashkenazi Jewish Case-Parent Trios: Findings for Bipolar I Disorder and Schizophrenia. Am J of Hum Genet, 77:918-936.

Bjornsson HT, Fallin MD, Feinberg AP. (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet. 20(8):350-8.

Fallin D, Cohen A, Essioux L, Chumakov I, Blumenfeld M, Cohen D, Schork N. (2001) Genetic Analysis of Case/Control Data Using Estimated Haplotype Frequencies: Application to APOE Locus Variation and Alzheimer's disease. Genome Research, 11:143-151.

Schork N, Fallin D, Lanchbury J. (2000) Single Nucleotide Polymorphisms and the Future of Genetic Epidemiology. Clinical Genetics, 58( 4): 250-264.

Fallin D & Schork N. (2000) Accuracy of Haplotype Frequency Estimation for Biallelic Loci via the Expectation-Maximization Algorithm for Unphased Diploid Genotype Data. Am J Hum Genet. 67(4):947-59.