Research and Professional Experience
My main research interest is studying risk factors for cardiovascular and kidney disease. I am particularly interested in factors mediating the excess risk of cardiovascular disease among patients with various stages of kidney disease, from pre-clinical to end-stage as well as improving estimates of kidney disease prevalence and consequences. I have enjoyed looking at genetic and biologic risk factors as well as innovative epidemiologic methods and statistical analysis in the conduct of this research. The ultimate objective of this research is to decrease the enormous burden of cardiovascular and kidney disease through developing the scientific basis for behavioral and pharmacologic interventions. More recently I developed an interest in the vascular basis of dementia, co-leading a team in the design of the ARIC Neurocognitive Study. In addition, methodologic tools and pathophysiologic insights are sought which would have broader applications.
Epidemiology and clinical research is most productive when done collaboratively. I am fortuante to play a leadership role in a number of large collaborations (Principle investigator: CKD Prognosis Consortium, ARIC Field Center, CKD-EPI Hopkins site, CKD Biomarkres Consortium Hopkins site) and contribute to many others.
Program leadership at Hopkins: * Director, Cardiovascular Epidemiology Training Program (T32HL07024) and area of concentration.
* Director, George W. Comstock Center for Public Health Research and Prevention (GWCC). GWCC includes 2 units with 26 staff members. The Health Monitoring Unit (HMU) on Pennsylvania Avenue includes the CLUE studies and leads training and public health activities. The Surveillance & Disease Prevention Unit (S&DP) on the square in Hagerstown, Maryland, houses the ARIC study (includes county-wide heart disease surveillance), CHS, GEM and SHHS.
My research projects include leadership roles in:
* Atherosclerosis Risk in Communities Study - A prospective study of 15,792 individuals recruited in 1986-1988 and followed to 2012 for cardiovascular disease and a wide range of other conditions. The study also includes community surveillance for heart disease incidence trends in four communities. This NHLBI funded multi-center contract provides the basis for a wide range of ancillary studies which results in a total productivity averaging more than 50 publications annually. We hope to have a 25-year follow-up examination in 2011-2013.
* Kidney Disease Collaborative Studies - Co-chairing the National Kidney Foundation guidelines on the definition and classification of kidney disease lead to an ongoing line of research. The (CKD-EPI) collaboration involves pooling individual level data to improve estimating equations for kidney function based on serum creatinine and novel markers. The 2009 CKD-EPI Creatinine Equation may replace the MDRD Study equation as the most widely used equation to estimate GFR. Additional studies focus on discovery and validation of novel markers for CKD staging and progression. We are currently helping to lead a collaborative effort to pool data from the leading cohorts on CKD prognosis to assist in refining the definition and staging of CKD.
* NHANES Kidney Disease Studies - Ongoing efforts to provide the most valid estimates of kidney disease prevalence in the U.S. as well as examine concurrent complications and consequences. Our grants measured and made available to the scientific community data on serum cystatin C and other novel measures of kidney function using stored specimen.
* CHOICE study - A prospective study of dialsis patients patients which includes a large specimen bank.
National committees: My role as vice-chair of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (KDOQI) workgroup for the Clinical Practice Guideline “Chronic Kidney Disease: Evaluation, Classification and Stratification” has lead to ongoing involvement in the international effort to address the public health burden of chronic kidney disease. This has included contributing to Kidney Disease Improving Global Outcomes(KDIGO) initiative planning controversies meetings in 2004 and 2009 and in 2007 attending NIH and CDC working groups.
Selected Publications
* Click for list of all Coresh J citations in PubMed [324 entries on 3/24/2012]
* Recent publication highlights - Kidney:
The Chronic Kidney Disease Prognosis Consortium [Writing committee: K Matsushita, M van der Velde, BC Astor, M Woodward, AS Levey, PE de Jong, J Coresh, RT Gansevoort]. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality: a collaborative meta-analysis of 21 general population cohorts. Lancet. 2010 Jun 12;375(9731):2073-81. [Corresponding author & Study chair]
Levey AS, de Jong PE, Coresh J, Nahas ME, Astor BC, Matsushita K, Gansevoort RT, Kasiske BL, Eckardt KU. The definition, classification and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2010 Dec 8.
Levey AS, Stevens LA, Schmid CH, Yaping (Lucy) Zhang L, Castro A*, MPH2, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). Development of a New Equation to Estimate Glomerular Filtration Rate and Comparsion to the Modification of Diet in Renal Disease Study Equation. Ann Int Med. 2009; 604-612.
Cardiovascular:
Selvin E, Steffes MW, Zhu H, Matsushita K, Wagenknecht L, Pankow J, Coresh J, Brancati FL. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010 Mar 4;362(9):800-11.
Genome-wide association papers:
Kottgen et al. New loci associated with kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):376-84.
Co-Senior author on: Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet. 41, 407-414 (2009).
In 2008 Co-senior author on Gout GWAS: Lancet. Oct 2008. DOI:10.1016/S0140-6736(08)61343-4
Middle author on GWAS publications on: Stroke - N Engl J Med. 2009; 360:1718. Blood pressure - Nat Genet. 2009 May 10. ECG QT interval Nat Genet. 2009 Apr; 41(4):388-9 In 2008: Height,
For genetic admixture collaborations see Wen-Hong (Linda) Kao's faculty web page.
Cognitive function: Alonso A, Mosley T, Gottesman R, Catellier D, Sharrett AR, Coresh J. Risk of dementia hospitalization associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study. J Neurol Neurosurg Psychiatry. 2009 Aug 19.
Basic science collaborations: Woodward OM, Köttgen A, Coresh J, Boerwinkle E, Guggino WB, Köttgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10338-42. Epub 2009 Jun 8.
* Frequently cited (5> 500 times; 40 >100 times):
Levey AS, Coresh J, Balk E, et al. National kidney foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Int Med 2003;139:137-147. Times Cited: 1,047
Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1-12. Times Cited: 1,012
Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA 2007; 298: 2038-2047. Times Cited: 630
Coresh J, Astor BC, McQuillan G, et al. Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am J Kidney Dis 2002; 39: 920-929. Times Cited: 376
Stevens LA, Coresh J, Greene T, et al. Medical progress - Assessing kidney function - Measured and estimated glomerular filtration rate. New Engl J Med 2006; 354: 2473-2483. Times Cited: 557
Levey AS, Coresh J, Balk E, et al. National kidney foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Int Med 2003;139:137-147. Times Cited: 1,047
Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1-12. Times Cited: 1,012
Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA 2007; 298: 2038-2047. Times Cited: 630
Coresh J, Astor BC, McQuillan G, et al. Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. Am J Kidney Dis 2002; 39: 920-929. Times Cited: 376
Stevens LA, Coresh J, Greene T, et al. Medical progress - Assessing kidney function - Measured and estimated glomerular filtration rate. New Engl J Med 2006; 354: 2473-2483. Times Cited: 557
