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Center for Global Health Faculty

William R. Bishai

Professor

Academic Degrees

  • MD
  • PHD

Departmental Affiliation

Departmental Address

CRB2, Rm 1.08; 1550 Orleans St. Baltimore, MD

Contact Information

Phone:
410-955-3507
Fax:
410-614-8173

Research and Professional Experience

Tuberculosis pathogenesis Anti-TB drugs Animal models of TB and other respiratory pathogens

Keywords

Molecular Microbiology and Immunology, Impact of Genome Information on Tuberculosis Research

Selected Publications

1: Jain SK, Hernandez-Abanto SM, Cheng QJ, Singh P, Ly LH, Klinkenberg LG, Morrison NE, Converse PJ, Nuermberger E, Grosset J, McMurray DN, Karakousis PC, Lamichhane G, Bishai WR. Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice. J Infect Dis. 2007 Jun 1;195(11):1634-42. Epub 2007 Apr 23. PMID: 17471433 [PubMed - indexed for MEDLINE]

2: Lun S, Bishai WR. Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis. J Biol Chem. 2007 Jun 22;282(25):18348-56. Epub 2007 Apr 11. PMID: 17428787 [PubMed - in process]

3: Williams EP, Lee JH, Bishai WR, Colantuoni C, Karakousis PC. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J Bacteriol. 2007 Jun;189(11):4234-42. Epub 2007 Mar 23. PMID: 17384187 [PubMed - in process]

4: Anzueto A, Bishai WR, Pottumarthy S. Role of oral extended-spectrum cephems in the treatment of acute exacerbation of chronic bronchitis. Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):S31-8. PMID: 17349461 [PubMed - in process]

5: Lamichhane G, Bishai W. Defining the 'survivasome' of Mycobacterium tuberculosis. Nat Med. 2007 Mar;13(3):280-2. No abstract available. PMID: 17342137 [PubMed - indexed for MEDLINE]

6: Agarwal N, Woolwine SC, Tyagi S, Bishai WR. Characterization of the Mycobacterium tuberculosis sigma factor SigM by assessment of virulence and identification of SigM-dependent genes. Infect Immun. 2007 Jan;75(1):452-61. Epub 2006 Nov 6. PMID: 17088352 [PubMed - indexed for MEDLINE]

7: Lamichhane G, Raghunand TR, Morrison NE, Woolwine SC, Tyagi S, Kandavelou K, Bishai WR. Deletion of a Mycobacterium tuberculosis proteasomal ATPase homologue gene produces a slow-growing strain that persists in host tissues. J Infect Dis. 2006 Nov 1;194(9):1233-40. Epub 2006 Oct 2. PMID: 17041849 [PubMed - indexed for MEDLINE]

8: Raghunand TR, Bishai WR. Mapping essential domains of Mycobacterium smegmatis WhmD: insights into WhiB structure and function. J Bacteriol. 2006 Oct;188(19):6966-76. PMID: 16980499 [PubMed - indexed for MEDLINE]

9: Agarwal N, Raghunand TR, Bishai WR. Regulation of the expression of whiB1 in Mycobacterium tuberculosis: role of cAMP receptor protein. Microbiology. 2006 Sep;152(Pt 9):2749-56. PMID: 16946269 [PubMed - indexed for MEDLINE]

10: Raghunand TR, Bishai WR. Mycobacterium smegmatis whmD and its homologue Mycobacterium tuberculosis whiB2 are functionally equivalent. Microbiology. 2006 Sep;152(Pt 9):2735-47. PMID: 16946268 [PubMed - indexed for MEDLINE]

11: Hernandez-Abanto SM, Woolwine SC, Jain SK, Bishai WR. Tetracycline-inducible gene expression in mycobacteria within an animal host using modified Streptomyces tcp830 regulatory elements. Arch Microbiol. 2006 Dec;186(6):459-64. Epub 2006 Aug 30. PMID: 16944099 [PubMed - indexed for MEDLINE]

12: Geiman DE, Raghunand TR, Agarwal N, Bishai WR. Differential gene expression in response to exposure to antimycobacterial agents and other stress conditions among seven Mycobacterium tuberculosis whiB-like genes. Antimicrob Agents Chemother. 2006 Aug;50(8):2836-41. PMID: 16870781 [PubMed - indexed for MEDLINE]

13: Nuermberger E, Rosenthal I, Tyagi S, Williams KN, Almeida D, Peloquin CA, Bishai WR, Grosset JH. Combination chemotherapy with the nitroimidazopyran PA-824 and first-line drugs in a murine model of tuberculosis. Antimicrob Agents Chemother. 2006 Aug;50(8):2621-5. PMID: 16870750 [PubMed - indexed for MEDLINE]

14: Bishai WR. Macrolide immunomodulatory effects and symptom resolution in acute exacerbation of chronic bronchitis and acute maxillary sinusitis: a focus on clarithromycin. Expert Rev Anti Infect Ther. 2006 Jun;4(3):405-16. Review. PMID: 16771618 [PubMed - indexed for MEDLINE]

15: Raghunand TR, Bishai WR, Chen P. Towards establishing a method to screen for inhibitors of essential genes in mycobacteria: evaluation of the acetamidase promoter. Int J Antimicrob Agents. 2006 Jul;28(1):36-41. Epub 2006 Jun 6. PMID: 16757153 [PubMed - indexed for MEDLINE]

16: Jain SK, Paul-Satyaseela M, Lamichhane G, Kim KS, Bishai WR. Mycobacterium tuberculosis invasion and traversal across an in vitro human blood-brain barrier as a pathogenic mechanism for central nervous system tuberculosis. J Infect Dis. 2006 May 1;193(9):1287-95. Epub 2006 Mar 28. PMID: 16586367 [PubMed - indexed for MEDLINE]

17: Rosenthal IM, Williams K, Tyagi S, Peloquin CA, Vernon AA, Bishai WR, Grosset JH, Nuermberger EL. Potent Twice-Weekly Rifapentine-containing Regimens in Murine Tuberculosis. Am J Respir Crit Care Med. 2006 Jul 1;174(1):94-101. Epub 2006 Mar 30. PMID: 16574936 [PubMed - in process]

18: Williams KN, Bishai WR. Clarithromycin extended-release in community-acquired respiratory tract infections. Expert Opin Pharmacother. 2005 Dec;6(16):2867-76. Review. PMID: 16318437 [PubMed - indexed for MEDLINE]

19: Nuermberger E, Helke K, Bishai WR. Low-dose aerosol model of pneumococcal pneumonia in the mouse: utility for evaluation of antimicrobial efficacy. Int J Antimicrob Agents. 2005 Dec;26(6):497-503. Epub 2005 Nov 9. PMID: 16289711 [PubMed - indexed for MEDLINE]

20: Nuermberger E, Tyagi S, Williams KN, Rosenthal I, Bishai WR, Grosset JH. Rifapentine, moxifloxacin, or DNA vaccine improves treatment of latent tuberculosis in a mouse model. Am J Respir Crit Care Med. 2005 Dec 1;172(11):1452-6. Epub 2005 Sep 8. PMID: 16151038 [PubMed - indexed for MEDLINE]

      
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