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Center for Global Health Faculty

Brad Astor

Brad Astor

Academic Degrees

Departmental Address

2024 East Monument Suite 2-600

Contact Information

Phone:
410-502-2779
Fax:
410-955-0476
Link:
SciVal Experts Research Profile

Research and Professional Experience

Dr. Astor’s research is focused on the interaction between kidney disease and cardiovascular disease, and their impact on the population. His research involves cohort studies of individuals with kidney failure (e.g., Choices for Healthy Outcomes in Caring for ESRD [CHOICE] Study), individuals with chronic kidney disease (e.g., Chronic Renal Insufficiency Cohort [CRIC] Study), and the general population (e.g., Atherosclerosis Risk in Communities [ARIC] Study), as well as utilizing publicly available datasets (e.g., National Health and Nutrition Examination Survey [NHANES]). These studies are undertaken in an attempt to better understand the connection between kidney disease and cardiovascular disease in the population, and identify areas of intervention to minimize the burden of these diseases.

Keywords

epidemiology, kidney, renal, nephrology, cardiovascualr, anemia, dialysis, vascular access, etiology, risk factors, observational studies, meta-analysis, ARIC, AASK, NHANES

Honors and Awards

2004  Faculty Innovation Fund

2002  Harry and Jeanette Weinberg Endowment Cardiovascular Research Award

2000  Charlotte Silverman Fellowship

1999  Mary B. Meyer Award

1999  Delta Omega Public Health Honorary Society Alpha Chapter Scholarship

1999  Jean Coombs Award for Student Research in Epidemiology

Selected Publications

Click here for full PubMed listing of Dr. Astor's publications

 

Astor BC, Coresh J, Powe NR, Eustace JA, Klag MJ. Relation between gender and vascular access complications in hemodialysis patients. Am J Kidney Dis 2000;36:1126-1134.

 

Astor BC, Eustace JA, Powe NR, Klag MJ, Sadler J, Fink NE, Coresh J. Timing of nephrologist referral and arteriovenous access use: the CHOICE Study. Am J Kidney Dis 2001;38:494-501.

 

Astor BC, Muntner M, Levin A, Eustace JA, Coresh J. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 2002;162:1401-1408.

 

Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2002;41:1-12.

 

Astor BC, Arnett DK, Brown A, Coresh J. Association of kidney function and hemoglobin with left ventricular morphology among African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 2004;43:836-845.

 

Coresh J, Byrd-Holt D, Astor BC, Briggs JP, Eggers PW, Lacher DA, Hostetter TH. Chronic kidney disease awareness, prevalence and trends among US adults, 1999-2000. J Am Soc Nephrol 2005;16:180-188.

 

Astor BC, Eustace JA, Powe NR, Klag MJ, Fink NE, Coresh J. Type of vascular access and survival among incident hemodialysis patients: the CHOICE Study. J Am Soc Nephrol 2005;16:1449-1455.

 

Astor BC, Coresh J, Heiss G, Pettitt D, Sarnak MJ. Kidney function and anemia as risk factors for coronary heart disease and mortality: The Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2006;151:492-500.

 

Hallan S, Astor B, Lydersen S. Estimating glomerular filtration rate in the general population: the second Health Survey of Nord-Trondelag (HUNT II). Nephrol Dial Transplant 2006;21:1525-1533.

 

Coresh J, Astor BC. Decreased kidney function in the elderly: clinical and preclinical, neither benign. Ann Intern Med 2006;145:299-301.

 

Astor BC, Hallan SI, Miller ER III, Yeung E, Coresh J. Glomerular filtration rate, albuminuria and risk of cardiovascular and all cause mortality in the US population. Am J Epidemiol 2008;167:1226-34

 

Astor BC, *Yi S, Hiremath L, Corbin T, Pogue V, Wilkening B, Peterson B, Lewis J, Lash JP, Van Lente F, Gassman J, Wang X, Bakris G, Appel LJ, Contreras G. N-terminal prohormone brain natriuretic peptide (NT-proBNP) as a predictor of cardiovascular disease and mortality in African Americans with hypertensive kidney disease: the African American Study of Kidney Disease and Hypertension (AASK). Circulation 2008;117:1685-92.

 

Melamed ML, Michos ED, Post W, Astor BC. 25-hydroxyvitamin D Levels and the risk of mortality in the general population. Arch Intern Med 2008:168:1629-37.

 

Dehghan A, Kottgen A, Yang Q, Hwang SJ, Kao WH, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet 2008; published online October 1. DOI:10.1016/S0140-6736(08)61343-4.

 

*Bash LD, Selvin E, Steffes MW, Coresh J, Astor BC. Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: The Atherosclerosis Risk in Communities (ARIC) Study. Arch Intern Med 2008;168:1-8.

 

*Bash LD, Erlinger TP, Coresh J, Marsh-Manzi J, Folsom AR, Astor BC. Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 2009; 53:596-605.

 

*Yi S, Selvin E, Rohrmann S, Basaria S, Menke A, Rifai N, Guallar E, Platz EA, Astor BC. Endogenous sex steroid hormones and measures of chronic kidney disease in a nationally representative sample of men. Clin Endocrinol 2008; 71:246-52.

 

Köttgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, Smith AV, Arking DE, Astor BC, Boerwinkle E, Ehret GB, Ruczinski I, Scharpf RB, Ida Chen YD, de Boer IH, Haritunians T, Lumley T, Sarnak M, Siscovick D, Benjamin EJ, Levy D, Upadhyay A, Aulchenko YS, Hofman A, Rivadeneira F, Uitterlinden AG, van Duijn CM, Chasman DI, Paré G, Ridker PM, Kao WH, Witteman JC, Coresh J, Shlipak MG, Fox CS. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet 2009; 41:712-17.

 

*Bash LD, Coresh J, Köttgen A, Parekh RS, Fulop T, Wang Y, Astor BC. Defining incident chronic kidney disease in the research setting: the ARIC Study. Am J Epidemiol. 2009; 170:414-24.

 

Astor BC, Levey AS, Stevens LA, Van Lente F, Selvin E, Coresh J. Method of glomerular filtration rate estimation affects prediction of mortality risk. J Am Soc Nephrol 2009; 20:2214-22.

 

*Bash LD, Astor BC, Coresh J. Risk of Incident ESRD: A Comprehensive Look at Cardiovascular Risk Factors and 17 Years of Follow-up in the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2009; 55:31-41.

*Indicates Dr. Astor's trainee's publication

Book Chapters

Shatin D, Bright RA, Astor BC. Databases for studying the epidemiology of implanted medical devices. In: Johnson FE, Virgo KS, editors. The Bionic Patient. St. Louis: Mosby, 2005.

 

 

 

ARIC Study

ARIC Carotid MRI Study

MESA Air Study

bastor@jhsph.edu

Projects

  • Information Health Survey of Nord-Trondelag County (HUNT II)

      
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