Center for Global Health Faculty

Director, Center on Aging and Health

Academic Degrees

Departmental Address

Contact Information

Email:

lfried+jhmi.edu

Phone:

(410) 955-0491

Fax:

410-614-9625

Link:

Personal Website

Link:

SciVal Experts Research Profile

Research and Professional Experience

Dr. Fried is the Director of the Center on Aging and Health, Director of the Division of Geriatric Medicine and Gerontology and the Director of the Training Program in Clinical and Population-based Research on Aging in the Bloomberg School of Public Health. She is a Professor of Medicine, Epidemiology, Health Policy and Nursing at the Johns Hopkins Medical Institutions. Her core research interests are prevention and health promotion for older adults, with particular emphasis on the discovery of the causes of frailty and disability and their prevention. Dr. Fried is the Principal Investigator of major population-based research projects, including 1) the Women’s Health and Aging Studies I, II and III, which are dedicated to determining the causes and consequences of disability and frailty in older women; 2) the Cardiovascular Health Study, a multicenter prospective observational study of the causes and consequences of cardiovascular diseases in older men and women; 3) the Experience Corps program, a community-based program designed to bring the skills and time of older adults into public elementary schools to improve the educational outcomes for the children, while also being a health promotion program for the older adults; 4) the GEM (Gingko Evaluation for Memory) randomized, controlled trial to determine whether gingko biloba prevents dementia and cognitive decline in older adults; and 5) the Johns Hopkins Older Americans Independence Center, a Medical Institutions-wide, multidisciplinary initiative to discover the causes of frailty in older adults. Each of these research programs are described more fully elsewhere on this web site. She has published numerous articles on the causes and consequences of frailty and disability with aging, and both clinical and population-based strategies for prevention for older adults.

Dr. Fried is a board-certified internist and geriatrician, with postdoctoral training at the Johns Hopkins Medical Institutions in geriatrics, general internal medicine and epidemiology (cardiovascular and aging). She received her M.D. from Rush Medical College and M.P.H. from the Johns Hopkins University School of Hygiene and Public Health. Dr. Fried was named a Kaiser Faculty Scholar in General Internal Medicine, and is the recipient of a National Institute on Aging MERIT Award, as well as numerous awards for her research accomplishments and her mentoring. She is a member of the Institute of Medicine.

Keywords

Epidemiology, aging, frailty and disability, Center on Aging and Health, Clinical and Population-based Research on Aging, Women’s Health and Aging, women's health, women and aging, frailty, Cardiovascular Health Study, Gingko Evaluation for Memory, Older Americans Independence Center, Experience Corps

Honors and Awards

Kaiser Faculty Scholar in General Internal Medicine

Member, Institute of Medicine

NIA National Advisory Council on Aging.

Marion Spencer Fay National Board Award for the year 2000 Distinguished Woman Physician/Scientist. National Board for Women in Medicine, The Medical College of Pennsylvania.

Herbert A. DeVries Distinguished Research Award, Council on Aging and Adult Development of The American Alliance for Health, Physical Education, Recreation and Dance.

Archstone Award, American Public Health Association, Section on Gerontological Health, to Dr. Fried and Mr. Marc Freedman as Co-Founders of the Experience Corps.

Maxwell Pollack Award, Gerontological Society of America, to Dr. Fried and Mr. Marc Freedman as Co-Founders of the Experience Corps.

Fellow, Gerontological Society of America.

MERIT Award, National Institute on Aging, NIH

Elected Member, Institute of Medicine.

Elected Member, Association of American Physicians.

Named as one of Maryland’s “Top 100 Women” for the year 2003.

National Library of Medicine Award as a “Living Legend in Medicine”, Named by the American Medical Women’s Association, the National Library of Medicine and members of Congress from Maryland.

Irving Wright Award of Distinction, American Federation for Aging Research.

Mary Betty Stevens Award, American College of Physicians, Maryland Chapter.

Selected Publications

(selected of 218) Fried LP, Tangen CM., Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracey R, Kop W, Burke G, McBurnie MA. Frailty in older adults: Evidence for a phenotype. J Gerontol Med Sci 2001:56;M146-56.

Newman AB, Gottdiener JS, McBurnie MA, Hirsch CH, Kop WJ, Tracy R, Walston JD, Fried LP, for the Cardiovascular Health Study Research Group. Associations of subclinical cardiovascular disease with Frailty. J Gerontol Med Sci 2001:56;M1158-66.

Burke GL, Bild DE, Fried LP, Nunn C, Arnold AM. Factors Associated with healthy aging: The Cardiovascular Health Study. J Am Geriatr Soc 2001:49;254-262.

Rubin GS, Bandeen-Roche K, Huang GH, Munoz B, Schein OD, Fried LP, West SK. The association of multiple visual impairments with subjective physical disability:SEE Project. Invest Ophthalmol Vis Sci 2001:42;64-72.

Rantanen T, Guralnik JM, Ferrucci L, Penninx BW, Leveille S, Sipila S, Fried LP. Coimpairments as predictors of severe walking disability in older women. J Am Geriatr Soc 2001:49;21-27.

Simonsick EM, Kasper JD, Guralnik JM, Bandeen-Roche K, Ferrucci L, Hirsch R, Leveille S, Rantanen T, Fried LP. Severity of upper and lower extremity functional limitation: scale development validation with self-report and performance-based measures of physical function. J Gerontol B Psychol Sci Soc Sci 2001:56;S10-19.

Fried LP, Young Y, Rubin G, Bandeen-Roche K. Self-reported preclinical disability identifies older women with early declines in performance and early disease. J Clin Epidemiol 2001:54;889-901.

Cheitlin MD, Gerstenblith G, Hazzard WR, Pasternak R, Fried LP, Rich MW, Krumholz HM, Peterson E, Reves JG, McKay C, Saksena S, Shen WK, Akhtar M, Brass LM, Biller J. AHA Conference Proceedings: Do existing databases hold the answers to clinical questions in geriatric cardiovascular disease and stroke? Executive Summary. Database Conference, January 27-30, 2000. Washington, DC, USA. Circulation. 2001 Aug 14;104:E39.

Cheitlin MD, Gerstenblith G, Hazzard WR, Pasternak R, Fried LP, Rich MW, Krumholz HM, Peterson E, Reves JG, McKay C, Saksena S, Shen WK, Akhtar M, Brass LM, Biller J. Database Conference January 27-30, 2000, Washington D.C. - Do Existing Databases Answer Clinical Questions about Geriatric Cardiovascular Disease and Stroke? Am J Geriatr Cardiol. 2001 Jul-Aug;10(4):207-23.

Volpato S, Guralnik JM, Ferrucci L, Balfour J, Chaves P, Fried LP, Harris TB. Cardiovascular disease, interleukin-6, and risk of mortality in older women: The Women’s Health and Aging Study. Circulation 2001:103;947-953.

Jylha M, Guralnik JM, Balfour JL, Fried LP. Walking difficulty, walking speed and age as predictors of self-rated health. J Gerontol Med Sci.2001:56;M609-M617.

Coffey CE, Ratcliff G, Phil D, Saxton JA, Bryan RN, Fried LP, Lucke JF. Cognitive Correlates of Human Brain Aging: A quantitative magnetic resonance imaging investigation. J Neuropsychiatry Clin Neurosci 2001;13:471-485.

Whetstone LM, Hiscock BS, Fried LP. The Physical Functioning Inventory: A procedure for assessing physical function in adults. J Aging and Health 2001;13:467-493.

Beckman H., Fried LP. The search for a job: bringing focus to a daunting task. West J Med. 2001 Jun;174(6):410-4.

Kop WJ, Gottdiener JS, Tangen CM, Fried LP, McBurnie MA, Walston J, Newman A, Hirsch C, Tracy RP. Inflammation and coagulation factors in persons >65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol 2001;15:419-424.

Newman AB, Yanez D, Harris T, Duxbury A, Enright PL, Fried LP. Weight change in old age and its associations with mortality. J Am Geriatr Soc 2001;49:1309-1318.

Arking DE, Krebsova A, Macek M Sr, Macek M Jr, Arking A, Mian S, Fried LP, Hamosh A, Dey S, McIntosh I, Dietz HC. Association of human aging with a functional variant of klotho. PNAS 2002;99:856-861.

McDermott MM, Ferrucci L, Simonsick EM, Balfour J, Fried LP, Linda S, Gibson D, Guralnik JM. The ankle brachial index change in lower extremity functioning over time: The Women’s Health and Aging Study. J Am Ger Soc 2002;50:238-246.

Chaves PHM, Ashar B, Fried LP. Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women: should the criteria currently used to define anemia in older women in the elderly be evaluated? J Am Geriatr Soc 2002;50:1257-1264.

Verreault R, Semba RD, Volpato S, Ferrucci L, Fried LP, Guralnik JM. Low serum vitamin D does not predict new disability and loss in muscle strength in older women. J Am Geriatr Soc 2002;50:912-917.

Onder G, Penninx BWJH, Lapuerta P, Fried LP, Ostir GV, Guralnik JM, Pahor M. Change in physical performance over time in older women: The Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 2002;57:M289-93.

Volpato S, Guralnik JM, Fried LP, Remeley AT, Cappola AR, Launer LJ. Serum thyroxine level and cognitive decline in euthyroid older women. Neurology 2002;58:1055-1061.

Volpato S, Blaum C, Resnick H, Ferrucci L, Fried LP, Guralnik JM. Comorbidities and impairments explaining the association between diabetes and lower extremity disability: The Women’s Health and Aging Study. Diabetes Care 2002;4:678-683.

Onder G, Penninx BW, Balkrishnan R, Fried LP, Chaves PHM, Williamson J, Carter C, Di Bari M, Guralnik JM, Pahor M. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study. Lancet 2002;359:926-930.

Friedman DM, Munoz B, West SK, Rubin GS, Fried LP. Falls and fear of falling: Which comes first? A longitudinal prediction model suggest strategies for primary and secondary prevention. JAGS 2002;50:1329-1335.

Crum RM, Puddey I, Gee GC, Fried LP. Reproducibility of two approaches for assessing alcohol consumption among older adults. Addiction Research and Theory 2002;10:373-385.

Chaves PHM, Ashar B, Fried LP. Looking at the relationship between hemoglobin concentration and prevalent mobility difficulty in older women: should the criteria currently used to define anemia in older women in the elderly be evaluated? J Am Geriatr Soc. 2002 Jul;50(7):1257-64.

Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, Gottdiener J, Fried LP for the CHS Investigators. Frailty and activation of the inflammation and coagulation systems with and without comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 2002:162;23323-41.

Ostir GV, Volpato S, Fried LP, Chaves P, Guralnik JM. Reliability and sensitivity to change assessed for a summary measure of lower body function. Results from the Women’s Health and Aging Study. J Clin Epidemiol 2002;55:916.