Center for Global Health Faculty

Academic Degrees

Departmental Address

Contact Information

Email:

cgaydos+jhmi.edu

Phone:

410-614-0932

Fax:

410-614-9775

Link:

Personal Website

Link:

SciVal Experts Research Profile

Research and Professional Experience

Dr. Gaydos has extensive laboratory expertise with over 40 years experience in microbiology and received her doctoral degree on studies of C. pneumoniae. She has worked for the last 19 years in the chlamydia research field doing original research developing DNA amplification tests for Chlamydia trachomatis, C. pneumoniae, C. psittaci. Trichomonas vaginalis, Neissseria gonorrhoeae, Mycoplasma genitalium, and agents of genital ulcer disease. She sequenced the 16S rRNA gene for C. pneumoniae and developed a polymerase chain reaction (PCR) assay specific for C. pneumoniae. She has studied populations for the epidemiological association of C. pneumoniae with respiratory diseases, community acquired pneumonia, and heart disease, as well as performed primate animal studies with C. pneumoniae. All of these studies used analyses by culture, in situ hybridization, and PCR, as well as serology (microimmunofluorescence).

Dr. Gaydos has set up and evaluated a method for assessing clinical cervical specimen cellular adequacy, as well as the persistence of C. trachomatis DNA after antibiotic therapy.

Additionally, Dr. Gaydos is currently working on an Internet project for enhanced community chlamydia screening using self-administered vaginal swabs, which demonstrates an effective method for reaching women who may not attend clinics.

The laboratory Dr. Gaydos works in has served as the Core Diagnostic Laboratory and as the Reference laboratory for many national and international grants for collaborative studies of sexually transmitted diseases. The laboratory is CLIA-licensed and State of Maryland certified for diagnostic assays for chlamydia.

Keywords

• Chlamydia trachomtis
• C. pneumoniae
• STDs
• STIs
• Biothreat
• diagnostics
• adolescents
• cost effectiveness
• trichomonas
• mycoplasma

Honors and Awards

American Sexually Transmitted Diseases Association Achievement award 2008

Selected Publications

Joffe, A., C.A. Reitmeijer, S. Chung, N. Willard, J.B. Chapin, L.V. Lloyd, G.A. Waterfield, J.E. Ellen, C.A. Gaydos. Screening asymptomatic adolescent males for Chlamydia trachomatis in school-based health Centers using urine-based nucleic acid amplification tests. (in press).

Gift, T.L., C. A. Gaydos, C. K. Kent, J. M. Marrazzo, C. A. Rietmeijer, J. A. Schillinger, E. F. Dunne. The program cost and cost-effectiveness of screening men for chlamydia to prevent pelvic inflammatory disease in women. (in press).

Francis, S.C., C. K. Kent, J. D. Klausner, L. Rauch, R. Kohn, A. Hardick, C. A. Gaydos. Prevalence of rectal Trichomonas vaginalis and Mycoplasma genitalium in male patients at the San Francisco STD clinic, 2005-2006. Sex. Transmit. Dis. (in press).

Gift, T. L., D. R. Blake, C. A. Gaydos, J. M. Marrazzo. The Cost-Effectivness of Screening Men for Chlamydia trachomatis: A Review of the Literature. Sex. Transmit. Dis. (in press).

Yang, S. P. Ramachandran, A. Hardick, Y-H. Hsieh, C. Quianzon, M. Kuroki, J. Hardick, A. Kecojevic, A. Abeygunawardena, J. Zenilman, J. Melendez, V. Doshi, C. Gaydos, R. Rothman. Rapid PCR-based Diagnosis of Septic Arthritis by Early Gram-Type Classification and Pathogen Identification. J. Clin. Microbiol. 46:1386-1390, 2008.

Dunn, E. F., J. B. Chapin, C. A. Rietmeijer, C. K. Kent, J. M. Ellen, C. A. Gaydos, N. J. Willard, R. K., L. Lloyd, S. Thomas, N. Birkjukow, S. Chung, J. Klausner, J. A. Schillinger, L. E. Markowitz. Rate and predictors of repeat Chlamydia trachomatis infection among Males Sexually Transmitted Diseases. Sex. Transmit. Dis (in press).

Nevin, R. L., E. E. Shuping, K. D. Frick, J. C.Gaydos, C. A.Gaydos. Cost and Effectiveness of Chlamydia Screening Among Male Military Recruits: Markov Modeling of Complications Averted Through Notification of Prior Female Partners. Sex. Transmit. Dis. (in press).

Yang, S., R.E. Rothman, J. Hardick, M. Kuroki, A. Hardick, V. Doshi, P. Ramachandran, C. A. Gaydos. Rapid Polymerase Chain Reaction-based Screening Assay for Bacterial Biothreat Agents. Academ. Emerg.Med. 15:388-392, 2008.

Gaydos, C.A., Y-H Hsieh, J.S. Galbraith, M. Barnes, G. Waterfield, B. Stanton. Focus-on-Teens, sexual risk-reduction intervention for high-school adolescents: Impact on knowledge, change of risk-behaviors, and prevalence of sexually transmitted infections. Internat J. STD AIDS. (in press).

Gaydos, C.A., D.V. Ferrero, J. Papp. Laboratory aspects of screening males for Chlamydia trachomatis in the new millenium. Sex Transm. Dis. Dec, 2008 (in press).

Wood, B.J., P. Rizzo-Price, J. Holden, A. Hardick, T.C. Quinn, C.A. Gaydos. The microbicide tenofovir does not inhibit nucleic acid amplification tests for Chlamydia trachomatis and Neisseria gonorrhoeae in urine samples. J. Clin. Microbiol. 46: 763-765, 2008.

Blake, D., N. Maldeis, M.R. Barnes, A. Hardick, T.C. Quinn, C.A. Gaydos. Cost-effectiveness of screening strategies for Chlamydia trachomatis using cervical swabs, urine, and self-obtained vaginal swabs in an STD clinic setting. Sex Transmit. Dis. (in press).

Gaydos, C.A. C. Wright, B.J. Wood, G. Waterfield, S. Hobson, T. C. Quinn. Chlamydia trachomatis Re-infection Rates among Female Adolescents Seeking Rescreening in School Based Health Centers. Sex Transmit Dis 35:233-237, 2008.

Rogers, S. M., W.C. Miller, C.F. Turner, J. Ellen, J. Zenilman, R. Rothman, M. A. Villarroel, A. Al-Tayyib, P. Leone, C. Gaydos, L. Ganapathi, M. Hobbs, D. Kanouse. Concordance of Chlamydia trachomatis infections within sexual partnerships. Sex. Transmit. Inf. 84:23-28, 2008.

Miller, M., Y. Liao, A. Manchikanti Gomez, C. A. Gaydos, D. D’Mellow. Factors associated with prevalence and incidence of Trichomonas vaginalis among African American women in New York City who use drugs. J Infect Dis 197:503-509, 2008.

Hobbs, M.M., B. Van der Pol, P. Totten, C. A. Gaydos, A. Wald, T. Warren, R. L. Winer, R. L. Cook, C. D. Deal, M. E. Rogers, J. Schachter, K. K. Holmes, D. H. Martin. From the NIH: Proceedings of a Workshop on the Importance of Self-Obtained Vaginal Specimens for Detection of Sexually Transmitted Infections. Sex Transm Dis 35:8-13. 2008.

Blake, D. R., T.C. Quinn, C.A. Gaydos. Should asymptomatic males be included in chlamydia screening programs? Cost-effectiveness of Chlamydia Screening Among Male and Female Entrants to a National Job Training Program. Sex. Transmit. Dis. 35: 91-101, 2008.

Sampath. R., K.L. Russell, C. Massire, M.W. Eshoo, V. Harpin, L.B. Blyn, R. Melton, C. Ivy, T. Pennella, F. Li, H. Levene, T.A. Hall, B. Libby, N. Fan, D. J. Walcott, R. Ranken, M. Pear, A. Schink, J. Drader, D. Moore, D. Metzgar, L. Addington, R. Rothman, C.A. Gaydos, S. Yang, K. St. George, M.E. Fuschino, A. B. Dean, D. Stallknecht, G. Goekjian, S.Yingst, M. Monteville, M.D. Saad, C.A. Whitehouse, C. Baldwin, K. H. Rudnick, S.A. Hofstadler, S. M. Lemon and D.J. Ecker. Rapid Surveillance of the Global Spread of Emerging Influenza Virus Genotypes by Mass Spectrometry. PLoS ONE. May 2007, issue 5, e489.

Sutcliffe S, Giovannucci E, Gaydos CA, Viscidi RP, Jenkins FJ, Zenilman JM, Jacobson LP, De Marzo AM, Willett WC and Platz EA. Plasma antibodies against Chlamydia trachomatis, human papillomavirus and human herpesvirus type 8 infection in relation to risk of prostate cancer: a prospective study. Cancer Epidemiol Biomarkers Prev. 16:1573-80, 2007.