Most human viruses originated from wild animal populations (e.g. HIV, influenza, dengue, SARS, ebola, etc). My lab is working to identify the factors which allow viruses to cross from animals into humans and to develop systems to monitor the emergence of viruses before they reach epidemic levels.
Current projects include: 1) Hunter cohort study: monitor viruses among hunters living in and around biodiversity hotspots 2) Animal health study: catalog viruses in hunted animals and survey for wild animal ‘die-offs’ 3) Virus diversity study: characterize previously unknown viruses in human & animal populations 4) Rural health development project: provision of technical assistance and resources to aid in the development of local health infrastructure for provision of prevention and care for HIV and other infectious diseases
These projects are supported by laboratory and repository facilities in the USA and overseas laboratory sites
International Research Scientist Development Award (IRSDA), NIH Fogarty International Center, 1999-2006
Fulbright Fellowship, 1997-1998
National Science Foundation Graduate Research Fellowship, 1994-1997
Certificate of Distinction for Teaching, Harvard University, 1994
pathogen ecology and evolution
simian foamy virus
Sintasath DM, Wolfe ND, Lebreton M, Jia H, Garcia AD, Le Doux-Diffo J, Tamoufe U, Carr JK, Folks TM, Mpoudi-Ngole E, Burke DS, Heneine W, Switzer W (2009 ) Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon. Emerging Infectious Disease 15(2):175-84.
Switzer WM, Salemi M, Qari SH, Jia H, Gray RR, Katzourakis A, Marriott SJ, Pryor KN, Wolfe ND, Burke DS, Folks TM, Heneine W (2009) Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4. Retrovirology 2;6:9.
ND Wolfe (2008) An epidemiologist points to a fifth sort of human malaria. Nature 453:567 [journal club]
Goldberg TL, CA Chapman, K Cameron, T Saj, WB Karesh, ND Wolfe, SW Wong, ME Dubois, MK Slifka (2008) Serologic evidence for a novel poxvirus in endangered red colobus monkeys, Western Uganda. Emerging Infectious Disease 14: 801-803