BA, Biology, University of Rochester, 1980; MD, New York University School of Medicine, 1984; MPH, Johns Hopkins University School of Hygiene and Public Health, 1991
Dr. Weaver’s research interests involve the use of molecular epidemiology tools in the evaluation of populations exposed to occupational and environmental chemicals. The validation of exposure and early biological effect markers to improve clinical evaluation and medical surveillance is a primary focus. Identification of susceptible populations is an additional goal.
Her primary area of research is the impact of occupational and environmental toxicants on the kidney. Currently, she is studying clinical and early biological effect markers (urinary retinol-binding protein and N-acetyl-beta-D-glucosaminidase (NAG)) for the renal system in lead workers in South Korea. This longitudinal study is evaluating the effects of lead and cadmium exposure on a range of renal outcomes. Interaction with genetic susceptibility factors and chronic diseases, such as hypertension, is also a focus in this work. She has also studied biomarkers for benzene exposure in urban populations, including children.
Dr. Weaver’s clinical activities also involve biomarker applications, thus complimenting her research. These activities have included management of a medical surveillance program for cadmium exposed workers in which blood and urine cadmium and beta-2 microglobulin were monitored. In addition, she was a co-investigator in a medical surveillance program for former workers at Los Alamos National Laboratory. This project involves workers with many previous exposures and uses the lymphocyte proliferation test to assess for presence of sensitization from previous beryllium exposure.
Honors and Awards
Magna cum laude, University of Rochester, 1980
Phi Beta Kappa, University of Rochester, 1980
Recipient, Occupational Physicians Scholarship Fund Award, 1990-92
Delta Omega Honorary Public Health Society - Alpha Chapter, Johns Hopkins University School of Public Health and Hygiene, 1991
Ho-Ching Yang Memorial Faculty Fellowship in Cancer Prevention, 1995
AMTRA (Advising, Mentoring & Teaching Recognition Award), Johns Hopkins School of Public Health Student Assembly, 2009,
Teaching Excellence for "Clinical Environmental and Occupational Toxicology", 2009-current
environmental nephrotoxicants, lead, retinol-binding protein, N-acetyl-beta-D-glucosaminidase (NAG), cadmium, molecular epidemiology, medical surveillance, occupational and environmental chemical exposures, biomarkers
Weaver, VM and Fadrowski JF. Kidney Disease in Children and the Environment. In: Landrigan PJ and Etzel RA (eds.) Textbook of Children’s Environmental Health. Oxford University Press. New York, New York, 2014, pp 447-457.
Shelley R, Kim N-S, Parsons P, Lee B-K, Agnew J, Jaar B, Steuerwald A, Matanoski GM, Fadrowski J, Schwartz BS, Todd A, Simon D, Weaver VM. Uranium Associations with Kidney Outcomes Vary by Urine Concentration Adjustment Method. Journal Of Exposure Science And Environmental Epidemiology. 2014;24:58–64
Weaver VM, Fadrowski J, and Jaar BG. Does calcium disodium ethylenediaminetetraacetic acid (CaEDTA) slow chronic kidney disease progression? (Invited editorial) Am J Kidney Dis. 2012;60(4):503-506. http://dx.doi.org/10.1053/j.ajkd.2012.07.006
Weaver VM, Kim N-S, Lee B-K, Parsons PJ, Spector J, Fadrowski J, Jaar BG, Steuerwald AJ, Todd AC, Simon D, and Schwartz BS. Differences in urine cadmium associations with kidney outcomes based on serum creatinine and cystatin C. Environ Res. 2011;111:1236–1242. doi:10.1016/j.envres.2011.07.012.
Spector J, Navas-Acien A, Fadrowski J, Guallar E, Jaar BG, Weaver VM. Associations of blood lead with estimated glomerular filtration rate using MDRD, CKD-EPI and serum cystatin C-based equations. Nephrology Dialysis Transplantation 2011; 26: 2786–2792 doi: 10.1093/ndt/gfq773.