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The Study of Liver Diseases in Uganda (SOLiD-Uganda) represents a consortium of investigators from Makere University, Mulago Hospital, the Rakai Health Sciences Program in Uganda and from Hopkins, NIAID, and UT-Southwestern in the US. Through a series of projects, our aim is to characterize the epidemiology of hepatitis B and C viral infection in Uganda and identify risk factors for liver cirrhosis and cancer. The interaction of HIV and hepatitis viruses, particularly in the context of antiretroviral treatment, is a major focus.