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Johns Hopkins is working on global health projects around the world. Use our search engine to explore our work in combating worldwide health threats.
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Projects
Cochrane Eyes and Vision Group
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The Cochrane Eyes and Vision Group aims to prepare, maintain and promote access to systematic reviews of interventions used to prevent or treat eye diseases and/or visual impairment. The work of the CEVG is carried out by over 300 members in more than 30 countries. The CEVG editorial team is located in London, UK and the CEVG US Project (CEVG@US) is a US-based satellite at the Johns Hopkins Bloomberg School of Public Health.
The CEVG@US is funded by the National Eye Institute. The overall objective of CEVG@US is to develop a critical mass of US-based vision researchers and practitioners who are trained in preparing and using systematic reviews.
The CEVG@US aims to accomplish four main goals: 1) Expand awareness of evidence-based health care in general and in eyes and vision specifically, 2) Develop a critical mass of vision researchers who are able to perform and interpret systematic reviews, and train others to do the same; 3) Develop a critical mass of clinicians who use the results of systematic reviews as an evidence base to guide their practice, and to train others to do the same; 4) Generate an increased number of systematic reviews in priority vision research areas, published in The...
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Projects
Small Molecule Protein-Glycan Inhibitors as Malaria Transmission-Blocking Therapeutics
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Malaria transmission entails development of the Plasmodium parasite in the mosquito. We have identified a critical interaction between an unknown ookinete lectin-like protein and a chondroitin sulfate glycosaminoglycan ligand on the mosquito midgut lumenal surface. We hypothesize that by disrupting this interaction through the use of small molecule inhibitors we can prevent parasite establishment in the mosquito and, subsequently, completely abrogate malaria transmission. This is a translational research grant proposal with the goal of taking our basic research understanding of Plasmodium-mosquito host interactions toward the development of novel highly potent malaria transmission-blocking therapeutics. Our first aim, the Complete molecular characterization of Plasmodium ookinete protein-midgut glycosaminoglycan interactions involves (1) identifying novel lectin-like ookinete molecules by glycan-affinity chromatography and mass spectrometry, (2) characterizing their functional role in vivo through the production of gene knockout parasites, (3) assessing their binding affinity for mosquito chondroitin glycosaminoglycans by protein array-surface plasmon resonance, and (3) gaining insight into the structure-function of the molecule(s) in complex with chondroitin glycosaminoglycan fragments and structural analogues by molecular modeling and x-ray crystallography. The second aim of the project, the Development of lead Plasmodium transmission-blocking glycan-mimetic compounds and assessment of their transmission-blocking potential involves identification of novel derivatives and analogues of...
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